ποΈ
Archived grant β no longer open
This grant has closed and is kept as a historical reference. Browse current grants for active opportunities.
grant
Promotion of ER+ Breast Cancer Progression in the Elderly
Organization UNIVERSITY OF PITTSBURGH AT PITTSBURGHLocation PITTSBURGH, UNITED STATESPosted 1 Aug 2021Deadline 31 Mar 2026 β οΈ
NIHUS FederalResearch GrantFY2025Adverse effectsAgeAge YearsAgingAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAquadiolB cell differentiation factorB cell stimulating factor 2B-Cell Differentiation FactorB-Cell Differentiation Factor-2B-Cell Stimulatory Factor-2BCDFBSF-2BSF2BehaviorBiologicalBiologyBlood PlasmaBreastBreast CancerBreast Cancer ModelBreast Cancer PatientBreast Cancer Risk FactorBreast Cancer cell lineBreast NeoplasmsBreast Tumor PatientBreast TumorsBreast tumor cell lineBreast tumor modelCancer CauseCancer EtiologyCancersCell Communication and SignalingCell SignalingChemotactic CytokinesChronicClinicalClinical TrialsCommon Rat StrainsCytokine ReceptorsDNA MethylationDe-implementationDeimplementationDevelopmentDiagnosisDimenformonDiogynDiogynetsDiseaseDisease-Free SurvivalDisorderDrugsER PositiveER+ERalphaERΞ±ESR1ESR1 geneElderlyEndocrine TherapyEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEstraceEstradiolEstradiol Receptor alphaEstradiol Receptor Ξ±Estradiol-17 betaEstradiol-17betaEstraldineEstrogen Receptor 1Estrogen Receptor alphaEstrogen Receptor Ξ±Estrogen ReceptorsEstrogen receptor positiveEstrogensEstroneEvent-Free SurvivalExhibitsFoundationsFutureGene ExpressionGeneralized GrowthGenomicsGoalsGrowthGuidelinesHPGFHepatocyte-Stimulating FactorHomologous Chemotactic CytokinesHormonal TherapyHybridoma Growth FactorIFN-beta 2IFNB2IL-6IL6 ProteinImmunoglobulin Enhancer-Binding ProteinIncidenceInflammationInflammatoryIntercrinesInterleukin-6InterventionIntracellular Communication and SignalingInvestigationMGI-2Malignant Breast NeoplasmMalignant NeoplasmsMalignant TumorMammary CancerMammary NeoplasmsMedicationMethylationModelingMolecularMyeloid Differentiation-Inducing ProteinNF-kBNF-kappa BNF-kappaBNFKBNR3A1Nuclear Factor kappa BNuclear Transcription Factor NF-kBOrganoidsOutcomeOvocyclinOvocylinPathogenesisPathway interactionsPatientsPersonsPharmaceutical PreparationsPhysiciansPhysiologicPhysiologicalPlasmaPlasma SerumPlasmacytoma Growth FactorPopulationProgynonRNA SeqRNA sequencingRNAseqRadiation therapyRadiotherapeuticsRadiotherapyRatRats MammalsRattusReceptor ActivationReceptor SignalingRecommendationRecurrenceRecurrentResearch TrainingReticuloendothelial System, Serum, PlasmaRiskRisk FactorsRoleSIS cytokinesSTAT3STAT3 geneSamplingScientistSentinel Lymph Node BiopsySentinel Node BiopsySignal TransductionSignal Transduction SystemsSignalingTechniquesTestingTherapeuticTherapeutic EstradiolTherapeutic EstrogenTherapeutic EstroneTissue GrowthTrainingTranscription Factor NF-kBTranslational ResearchTranslational ScienceTumor CellWomanWomen's mortalityadvanced ageage associatedage correlatedage dependentage linkedage relatedage specificagedaged groupaged groupsaged individualaged individualsaged peopleaged personaged personsaged populationaged populationsagesaging populationbiologicbiological signal transductionbreast cancer progressionbreast cancer riskcancer microenvironmentcancer progressioncareerchemoattractant cytokinechemokinecohortcostcytokinedeath among femalesdeath among womendeath in femalesdeath in womendeath rate among womendeath rate in womendevelopmentaldrug/agentelderly patientepigeneticallyepigenomicsestrogen receptor proteinestrophileestrophilinfemale deathfemale mortalitygeriatrichormone therapyimprovedindividuals with breast cancerinflammation markerinflammatory markerinflammatory modulationinnovateinnovationinnovativeinterferon beta 2kappa B Enhancer Binding Proteinmalignancymalignant breast tumormammary cancer modelmammary tumormammary tumor modelmid lifemid-lifemiddle agemiddle agedmidlifemortality among femalesmortality among womenmortality in femalesmortality in womenneoplasm progressionneoplasm/cancerneoplastic cellneoplastic progressionnew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetnuclear factor kappa betaolder patientontogenyover-treatmentovertreatmentpathwaypatient populationpatients with breast cancerpermissivenessperson with breast cancerpharmacologicpopulation agingradiation treatmentsenior citizensocial rolespectral imagespectral imageryspectrographspectrum imagespectrum imagerystandard carestandard treatmenttranscriptome sequencingtranscriptomic sequencingtranscriptomicstranslation researchtranslational investigationtreatment guidelinestreatment with radiationtumortumor growthtumor microenvironmenttumor progressionwomen's deathwomen's death rate
Applications closed.
Description preview
PROJECT SUMMARY / ABSTRACT
Breast cancer is the second leading cause of cancer-related deaths in women. Over two-thirds of all breast
cancer cases are considered estrogen receptor positive (ER+). Significantly, ER+ breast cancer incidence
correlates strongly with aging, rising to a peak incidence in women aged 70 years or older (elderly). Owing inβ¦
π
Start 7-day free trial β $29.99/mo βFull details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link β plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more β with email alerts and pipeline tracking.
$29.99 / month
- πEmail alerts for new matching tenders
- ποΈTrack tenders in your pipeline
- π°Filter by contract value
- π₯Export results to CSV
- πSave searches with one click