grant
Promoting tissue repair and functional recovery after spinal cord injury by targeting the microtubule regulatory protein Fidgetin-like 2.
Organization MICROCURES, INC.Location SANTA CRUZ, UNITED STATESPosted 15 May 2025Deadline 30 Apr 2027
NIHUS FederalResearch GrantFY202621+ years oldAcuteAdultAdult HumanAfter CareAfter-TreatmentAftercareAnimal ModelAnimal Models and Related StudiesAnimalsAreaAstrocytesAstrocytusAstrogliaAutopsyAxonBladderBladder Urinary SystemBody TissuesBruiseCell LocomotionCell MigrationCell MovementCellular MigrationCellular MotilityChronicClinicalClinical ChemistryCommon Rat StrainsContusionsCutaneousDWI (diffusion weighted imaging)DWI-MRIDataDiffusion MRIDiffusion Magnetic Resonance ImagingDiffusion Weighted MRIDiffusion weighted imagingDiffusion-weighted Magnetic Resonance ImagingDistalDropsDrug DeliveryDrug Delivery SystemsDuraDura MaterDysfunctionEncapsulatedEnzyme GeneEnzymesEvaluationExhibitsFaceFeasibility StudiesFemaleFormulationFunctional RegenerationFunctional disorderGeneralized GrowthGenesGoalsGrowthGrowth ConesHematologyHindlimbHistologicHistologicallyHistopathologyImageImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodInjuryIntrathecal InjectionsLeftLengthLesionLocomotor RecoveryMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMechanicsMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMedulla SpinalisMethodsMicro-tubuleMicrotubulesModelingMorphologyMotivationMotorNMR ImagingNMR TomographyNatural regenerationNerveNerve CrushNerve RegenerationNeuro-regenerationNeuronal InjuryNeuroregenerationNuclear Magnetic Resonance ImagingOligodendrocytesOligodendrocytusOligodendrogliaOligodendroglia CellPeripheral nerve injuryPersonsPhasePhysiopathologyPilot ProjectsPre-Clinical ModelPreclinical ModelsProcessProteinsPunch BiopsyRNA based therapeuticsRNA based therapyRNA therapyRatRats MammalsRattusRecoveryRecovery of FunctionReflexReflex actionRegenerationRegulatory ProteinReportingRestRodentRodentiaRodents MammalsSCI PatientsSTTRSafetySensoryShort interfering RNASiteSmall Business Technology Transfer ResearchSmall Interfering RNASpinal CordSpinal Cord ContusionsSpinal Cord TraumaSpinal TraumaSpinal cord injuredSpinal cord injurySpinal cord injury patientsStaining methodStainsSuspension substanceSuspensionsTestingTherapeuticTherapeutic UsesTissue GrowthTissuesTopical Drug AdministrationTopical applicationToxic effectToxicitiesTraumatic MyelopathyUnited StatesWeightWorkZeugmatographyadult youthadulthoodallodyniaapply topicallyastrocytic gliaaxon growthaxon growth cone guidanceaxon guidanceaxon regenerationaxonal growthaxonal regenerationcell motilityclinical significanceclinically significantcohortcompare to controlcompare treatmentcomparison controlcorneal healingcorneal regenerationdMRIdebilitating symptomdeliver topicallydensitydetermine efficacydiffusion tensor imagingdosageefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationevaluate efficacyexamine efficacyfacesfacialfunctional recoveryfunctional restorationgenetic regulatory proteingray matterhealingimagingimprovedinjuredinjuriesloss of functionmalemechanicmechanicalmodel of animalnano particlenano-sized particlenanoparticlenanoparticle therapynanosized particlenecropsynerve transectionnervous system regenerationneural circuitneural circuitryneural regenerationneurocircuitryneuron injuryneuroregenerativenovelontogenypathophysiologypenisperipheral nerve crush injuriespilot studypost treatmentpostmortempreventpreventingregenerateregenerated nerveregulatory gene productrestorationrestore functionrestore functionalityrestore lost functionsiRNAsubstantia albasubstantia griseasuccesssynaptic circuitsynaptic circuitrytherapeutic RNAtherapeutic nanoparticlestherapeutically effectivetissue repairtissue woundtopical administrationtopical deliverytopical drug applicationtopical drug deliverytopical instillationtopical treatmenttreat topicallytreatment comparisontrendurinary bladderweightswhite matterwoundwoundingwoundsyoung adultyoung adult ageyoung adulthood♀♂
Description preview
Traumatic spinal cord injuries (SCI) impact hundreds of thousands of people, and there are no therapies
available which can promote regeneration and clinical meaningful improvements in sensory, motor, or
autonomic function. Fidgetin-like 2 (FL2) is a microtubule (MT) regulatory protein that modulates MT
dynamics through its putative MT-severing…
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