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PROMOTING T CELL RECOVERY AFTER RADIATION INJURY WITH LONG-ACTING INTERLEUKIN 7

Organization DUKE UNIVERSITYLocation DURHAM, UNITED STATESPosted 1 Mar 2024Deadline 28 Feb 2026 ⚠️
NIHUS FederalResearch GrantFY2025Adaptive Immune SystemAnimalsAreaBlood CellsChimera ProteinChimeric ProteinsClinicalContractorDrugsExhibitsFDA approvedFusion ProteinGrippeHerpesvirus 1 (beta), MuridHumanIL-7IL-7 GeneIL7IL7 ProteinIL7 geneImmune GlobulinsImmune responseImmunoglobulinsInfectionInfluenzaInnate ImmunityInterleukin 7 PrecursorInterleukin 7 Precursor GeneInterleukin-7Interleukin-7 GeneLymphopoietin-1MarylandMature T-CellMature T-LymphocyteMedicationModelingModern ManMouse CytomegalovirusMurid herpesvirus 1Murine CytomegalovirusNative ImmunityNatural ImmunityNon-Specific ImmunityNonspecific ImmunityPeripheralPeripheral Blood CellPharmaceutical PreparationsPhenotypeProgenitor CellsProliferatingRadiationRadiation DoseRadiation Dose UnitRadiation InjuriesRadiation exposureRadiation induced damageRecombinantsRecoveryRiskT cell reconstitutionT cell responseT-CellsT-LymphocyteTestingTotal Body IrradiationViral DiseasesVirus DiseasesWhole-Body IrradiationWhole-Body Radiationacquired immune systemadaptive immunityantigen-specific T cellscell typecytokinedesigndesigningdrug/agenthost responseimmune system responseimmunoresponsein vitro testingin vivoirradiationirradiation injurymass casualtymouse modelmurine modelpre-clinical studypreclinical studyradiation damageradiation resistantradioresistantresistant to radiationstem cellsthymus derived lymphocyteviral infectionvirus infectionvirus-induced disease

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Description preview

This proposal is designed to assess a long-acting interleukin 7 product, NT-I7, on phenotypic and functional T cell recovery after total body irradiation at radiation doses simulating exposures that would be expected during a radiation mass casualty incident. Clinical-grade NT-I7 is produced by NeoImmuneTech, Inc. (Rockville, Maryland), and is a…

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