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Project Title: Structural studies of DNA repair required for human immune diversity using cryoEM

Organization UKRILocation United Kingdom
UKRIUK ResearchGrantActive
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Cells go to enormous lengths to protect the integrity of their genome but paradoxically, lymphocytes deliberately break their DNA during V(D)J recombination, a process that is essential to achieve the antibody diversity required for an effective adaptive immune system. The molecular details by which the RAG1+RAG2 recombinase breaks DNA are well…

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Project Title: Structural studies of DNA repair required for human immune diversity using cryoEM — UKRI | United Kingdom | Dev Procure