grant

Project 4: Defining the Molecular Natural History of Early and Progressive Pulmonary Fibrosis

Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 17 Sept 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY2025AffectAlveolarAnatomic SitesAnatomic structuresAnatomyAreaAtlasesAutomobile DrivingAutoregulationBiologyBiopsy SampleBiopsy SpecimenBody TissuesCell BodyCell Communication and SignalingCell NucleusCell SignalingCellsCellular AssayCellular biologyCommunicationComplexCross Sectional AnalysisCross-Sectional AnalysesCross-Sectional StudiesCross-Sectional SurveyDataDetectionDevelopmentDiseaseDisease Frequency SurveysDisease ProgressionDisorderDistalEndotheliumEventEvolutionFibroblastsFormalinGene ExpressionGene TranscriptionGeneral RadiologyGenesGenetic TranscriptionGenomicsHistologicHistologicallyHomeostasisImageIn SituIndividualInstructionInterruptionIntracellular Communication and SignalingLinkLungLung ParenchymaLung Respiratory SystemLung TissueLung Tissue FibrosisMachine LearningMediatingMicrobeadsMicrospheresModelingMolecularMolecular AnalysisMolecular FingerprintingMolecular ProfilingMultiomic DataNatural HistoryNatureNeighborhoodsNucleusOutcomeParaffin EmbeddingParticipantPathogenesisPatientsPhasePhysiological HomeostasisPositionPositioning AttributePulmonary FibrosisRNA ExpressionRadiographyRadiologyRadiology SpecialtyRegional AnatomyResolutionRiskRoentgenographySamplingSeriesSignal TransductionSignal Transduction SystemsSignalingSliceStructureStructure of parenchyma of lungSystemTechnologyTherapeuticTissue EmbeddingTissue SampleTissuesTranscriptionWorkbiological signal transductionbuild resiliencebuild resiliencycell assaycell biologycell typecohortdevelop resiliencedevelop resiliencydevelopmentaldrivingenhance resilienceenhance resiliencyexperimentexperimental researchexperimental studyexperimentsfacilitate resiliencefibrosis in the lunggenetic architectureimagingimprove resilienceimprove resiliencyincrease resilienceincrease resiliencyinsightinterstitiallung fibrosismachine based learningmolecular pathologymolecular profilemolecular signaturemultiple omic datanew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypre-clinicalpreclinicalpreservationprogramspromote resiliencepromote resiliencyradiological imagingresilience developmentresolutionsscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingspatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial integrationspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatially resolved transcriptomicsspatio transcriptomicstranscriptomics
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PROJECT SUMMARY
The advent of single cell RNA-sequencing (scRNA-seq) revolutionized our ability to study the molecular

mechanisms underlying pulmonary fibrosis (PF). Our group has leveraged this approach to identify novel cell

types and cell states, as well as to characterize the genetic architecture of gene expression in advanced PF.

While this…

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Project 4: Defining the Molecular Natural History of Early and Progressive Pulmonary Fibrosis — UNIVERSITY OF MICHIGAN | Dev Procure