grant
Project 4: Age-Related Changes in Gonadotropin Glycosylation and Function
Organization WICHITA STATE UNIVERSITYLocation WICHITA, UNITED STATESPosted 15 Apr 2009Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025Adaptor ProteinAdaptor Protein GeneAdaptor Signaling ProteinAdaptor Signaling Protein GeneAffectAffinityAgeAgingAntibodiesAssayBindingBinding Site DomainBinding SitesBioassayBiologicalBiological AssayBloodBlood Reticuloendothelial SystemBlood SerumCarbohydratesCell Communication and SignalingCell SignalingCell membraneCollaborationsCombining SiteComplexCryo-electron MicroscopyCryoelectron MicroscopyCultured CellsCytoplasmic MembraneDataDrugsELISAElectron CryomicroscopyEndocrine Gland SecretionEnzyme-Linked Immunosorbent AssayEstrogensExhibitsExpression SignatureFSH ReceptorsFamilyFamily PlanningFamily Planning ServicesFecundabilityFecundityFeedbackFertilityFollicle Stimulating HormoneFollicle Stimulating Hormone ReceptorFolliculostatinFollitropinG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG-Protein-Coupled ReceptorsGPCRGene Expression ProfileGenesGenitourinaryGenitourinary systemGlycansGlycoproteinsGoalsGonadotropinsHPG axisHormonalHormonesHumanHypophysisHypophysis CerebriImmunoassayImpairmentIn VitroIncubatedIndividualInhibin HormoneInterstitial Cell Stimulating HormoneInterstitial Cell-Stimulating HormoneIntracellular Communication and SignalingKO miceKnock-out MiceKnockout MiceKnowledgeLeuteinizing HormoneLigand BindingLigand Binding DomainLuteinizing HormoneLutropinMeasuresMediatingMedicationMedicineMenstrual cycleMetabolic GlycosylationModern ManMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMorbidityMorbidity - disease rateMuellerian inhibiting hormoneMullerian-inhibiting factorNull MouseObesityOligosaccharidesOutcomeOvarianOvarian FollicleOvaryPathway interactionsPatternPerimenopausalPerimenopausePharmaceutical PreparationsPhysiologicPhysiologicalPituitaryPituitary GlandPituitary Lutenizing HormonePituitary Nervous SystemPlasma MembranePolysaccharidesPopulationPositionPositioning AttributePrimatesPrimates MammalsReactive SiteReceptor ProteinRecombinant Luteinizing HormoneResistanceRhodopsinRoleRotationSerumSignal TransductionSignal Transduction SystemsSignalingSiteSteroid CompoundSteroidsStructureTM DomainTSH ReceptorsTherapeutic EstrogenTherapeutic HormoneTherapeutic LHThyroid Stimulating Hormone ReceptorsThyrotropin ReceptorTimeTransgenic OrganismsTransmembrane DomainTransmembrane RegionUrineUrogenitalUrogenital SystemUterine BleedingUterine hemorrhageVariantVariationVisual PurpleWomanaccess restrictionsadapter proteinadiposityage associated alterationsage associated changesage correlated alterationsage correlated changesage dependent alterationsage dependent changesage induced alterationsage induced changesage related alterationsage related changesage specific alterationsage specific changesagesaging associated alterationsaging associated changesaging correlated alterationsaging correlated changesaging dependent alterationsaging dependent changesaging induced alterationsaging induced changesaging related alterationsaging related changesaging specific alterationsaging specific changesalterations with ageanti-mullerian factoranti-mullerian hormonebiologicbiological signal transductionbone lossbone masschanges with agechildbearing agecollegecollegiateconformationconformationalconformational stateconformationallyconformationscorpulencecryo-EMcryoEMcryogenic electron microscopydifferential expressiondifferentially expresseddrug developmentdrug/agentenzyme linked immunoassayextracellularfertile agefertility assistancefertility interventionsfertility treatmentgene expression patterngene expression signatureglycosylationgranulosa cellhypothalamic pituitary gonadal axisin vitro activityin vivoinfertility treatmentinhibinmembermenopause transitionmullerian inhibiting substancemullerian regression factormullerian-inhibiting hormonemullerian-inhibitory substancenovelolder womenovarian follicular poolpathwayperi-menopausalperi-menopauseplasmalemmaprogramspsychologicpsychologicalreceptorreceptor bindingreceptor boundreceptor functionreceptor-mediated signalingrecruitreproductivereproductive agereproductive agingreproductive cell senescencereproductive senescencereproductive yearsresistantresponsesocial roletooltranscriptional differencestranscriptional profiletranscriptional signaturetransgenictransition to menopausetransitional menopausetranslational opportunitiestranslational potentialuterus bleedingvasomotor symptomsyoung woman
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Project Summary/Abstract – Project 4(Bousfield)
Our long-term goal is to understand how carbohydrate modulates the biological activity of follicle-stimulating
hormone (FSH). The human ovary becomes resistant to FSH stimulation with age and circulating FSH
concentrations rise, keeping serum estrogen concentrations normal until 2 years before the…
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