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Project 3: SARS CoV-2 Lung Organoid Interactions in Replication and Pathogenesis
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 1 Mar 2015Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY20252019 novel corona virus2019 novel coronavirus2019-nCoV3-D3-Dimensional3DARDSAcute Respiratory DistressAcute Respiratory Distress SyndromeAdult ARDSAdult RDSAdult Respiratory Distress SyndromeAirApicalApoplexyAsystoleBatsBiological MimeticsBiomimeticsBody TissuesBrain Vascular AccidentCOVID crisisCOVID epidemicCOVID pandemicCOVID-19COVID-19 crisisCOVID-19 epidemicCOVID-19 eraCOVID-19 global health crisisCOVID-19 global pandemicCOVID-19 health crisisCOVID-19 infectionCOVID-19 pandemicCOVID-19 periodCOVID-19 public health crisisCOVID-19 therapeuticsCOVID-19 virusCOVID-19 virus infectionCOVID-19 yearsCOVID19 infectionCOVID19 virusCV-19Cardiac ArrestCell Communication and SignalingCell SignalingCerebral StrokeCerebrovascular ApoplexyCerebrovascular StrokeCessation of lifeChinaChiropteraChronic DiseaseChronic IllnessCoV emergenceCoV-2CoV2CodeCoding SystemConfocal MicroscopyCoronaviridaeCoronaviridae InfectionsCoronavirusCoronavirus InfectionsCoronavirus Infectious Disease 2019CountryCulturing, in vitro Vertebrate, PrimaryDa Nang LungDataDeathDiseaseDisorderDrugsEnteralEntericEpidemicEpitheliasin GeneEpitheliumFutureGeneralized GrowthGlycoproteinsGoalsGrowthHeart ArrestHigh Throughput AssayHumanImaging ProceduresImaging TechnicsImaging TechniquesImmuneImmune Cell ActivationImmunesIn VitroInfectionInflammatoryInnate Immune ResponseIntestinalIntestinesIntracellular Communication and SignalingLiquid substanceLungLung DiseasesLung Respiratory SystemLung infectionsMERSMERS corona virusMERS coronavirusMERS coronavirus diseaseMERS virusMERS-CoVMERS-CoV diseaseMIS-CMainland ChinaMedicationMiceMice MammalsMiddle East Respiratory SyndromeMiddle East Respiratory Syndrome CoV diseaseMiddle East Respiratory Syndrome Corona VirusMiddle East Respiratory Syndrome CoronavirusMiddle East Respiratory Syndrome VirusMiddle East Respiratory Syndrome coronavirus diseaseMiddle East Respiratory Syndrome-CoVMiddle East Respiratory VirusMiddle East Respiratory coronavirusMiddle Eastern Respiratory SyndromeMiddle Eastern Respiratory Syndrome CoV diseaseMiddle Eastern Respiratory Syndrome Corona virusMiddle Eastern Respiratory Syndrome CoronavirusMiddle Eastern Respiratory Syndrome VirusMiddle Eastern Respiratory Syndrome coronavirus diseaseMiddle Eastern Respiratory Syndrome-CoVModelingModern ManMucosaMucosal TissueMucous MembraneMultiorgan Inflammatory Syndrome in ChildrenMultisystem Inflammatory Syndrome in ChildrenMurineMusOrganOrganoidsOrthocoronavirinaePRSS10PathogenesisPathogenicityPathway interactionsPatientsPatternPharmaceutical PreparationsPlayPneumoniaPrimary Cell CulturesPrimary InfectionPulmonary DiseasesPulmonary DisorderReagentReportingResearchResearch ResourcesResolutionResourcesRespiratory EpitheliumRiskRoleSARSSARS VirusSARS corona virusSARS corona virus 2SARS coronavirusSARS coronavirus diseaseSARS-Associated CoronavirusSARS-CO-V2SARS-COVID-2SARS-CoVSARS-CoV diseaseSARS-CoV-1SARS-CoV-2SARS-CoV-2 epidemicSARS-CoV-2 global health crisisSARS-CoV-2 global pandemicSARS-CoV-2 infectionSARS-CoV-2 inhibitorSARS-CoV-2 pandemicSARS-CoV-2 therapeuticsSARS-CoV2SARS-CoV2 infectionSARS-Related CoronavirusSARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-coronavirus-2 epidemicSARS-coronavirus-2 pandemicSARS-coronavirus-2 therapeuticsSARS-related corona virus 2SARS-related coronavirus 2SARSCoV2Severe Acute Respiratory CoronavirusSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory SyndromeSevere Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome CoV 2 epidemicSevere Acute Respiratory Syndrome CoV 2 pandemicSevere Acute Respiratory Syndrome CoV diseaseSevere Acute Respiratory Syndrome VirusSevere Acute Respiratory Syndrome corona virusSevere Acute Respiratory Syndrome coronavirusSevere Acute Respiratory Syndrome coronavirus diseaseSevere Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome coronavirus 2 epidemicSevere acute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 inhibitorSevere acute respiratory syndrome coronavirus 2 pandemicSevere acute respiratory syndrome coronavirus 2 therapeuticsSevere acute respiratory syndrome related corona virus 2Shock LungSignal TransductionSignal Transduction SystemsSignalingStiff lungStrokeStructure of respiratory epitheliumSurfaceSyndromeSystemTMPRSS2TMPRSS2 geneTechnologyTherapeuticTissue EngineeringTissue GrowthTissuesTropismViral DiseasesViral PathogenesisVirusVirus DiseasesVirus ReplicationWorkWuhan coronavirusadaptive immune responseairway epitheliumantagonismantagonistbioengineered tissuebiological signal transductionbiomarker arraybiomarker panelblock SARS-CoV-2block severe acute respiratory syndrome coronavirus 2bowelbrain attackcell typecerebral vascular accidentcerebrovascular accidentchronic disordercorona viruscorona virus emergencecoronavirus disease 2019coronavirus disease 2019 crisiscoronavirus disease 2019 epidemiccoronavirus disease 2019 global health crisiscoronavirus disease 2019 global pandemiccoronavirus disease 2019 health crisiscoronavirus disease 2019 infectioncoronavirus disease 2019 pandemiccoronavirus disease 2019 public health crisiscoronavirus disease 2019 therapeuticscoronavirus disease 2019 viruscoronavirus disease crisiscoronavirus disease epidemiccoronavirus disease pandemiccoronavirus disease-19coronavirus disease-19 global pandemiccoronavirus disease-19 pandemiccoronavirus disease-19 viruscoronavirus emergencecoronavirus infectious disease-19disease of the lungdisorder of the lungdrug/agentemergent CoVemergent corona virusemergent coronavirusemerging CoVemerging corona virusemerging coronavirusemerging epidemicengineered tissueenteral pathogenenteric pathogenenteropathogenepidemic concernepidemic potentialepidemic riskepidemic threatfluidglobal healthhCoV19high throughput screeninghigh-throughput drug screeninghuman diseasehuman modelhuman tissueimmune activationimprovedin vivoinfected with COVID-19infected with COVID19infected with SARS-CoV-2infected with SARS-CoV2infected with coronavirus disease 2019infected with severe acute respiratory syndrome coronavirus 2inhibit SARS-CoV-2inhibit severe acute respiratory syndrome coronavirus 2inhibitorinsightintestinal epitheliumintestinal pathogenintestine pathogenliquidlive cell imagelive cell imaginglive cellular imagelive cellular imaginglung developmentlung disordermarker panelmodel of humanmouse modelmultisystem inflammatory syndrome of childrenmurine modelmutantnCoVnCoV2new CoVnew corona virusnew coronavirusnew epidemicnovel CoVnovel corona virusnovel coronavirusnovel epidemicnucleoside inhibitorontogenypandemicpandemic diseasepathwaypediatric inflammatory multisystem syndromepulmonary infectionsresolutionsrespiratory tract epitheliumresponsescRNA sequencingscRNA-seqscreeningscreeningssevere acute respiratory syndrome coronavirus 2 global health crisissevere acute respiratory syndrome coronavirus 2 global pandemicsevere acute respiratory syndrome-CoVsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsmall molecular inhibitorsmall molecule inhibitorsocial rolestrokedstrokessuccesssynergismtherapeutics against COVID-19therapeutics against SARS-CoV-2therapeutics against SARS-coronavirus-2therapeutics against Severe acute respiratory syndrome coronavirus 2therapeutics against coronavirus disease 2019therapeutics for novel coronavirusthree dimensionalviral infectionviral multiplicationviral replicationvirus host interactionvirus infectionvirus multiplicationvirus pathogenesisvirus tropismvirus-induced diseasewet lungzoonotic CoVzoonotic coronavirus
Applications closed.
Description preview
PROJECT SUMMARY/ABSTRACT (Project 3)
Zoonotic coronaviruses (CoV) are responsible for three major epidemics/pandemics in the 21st century, including
Severe Acute Respiratory Coronavirus (SARS-CoV) in 2003 and Middle East Respiratory coronavirus (MERS-
CoV) in 2012. In Dec 2019, a third novel coronavirus (CoV) designated SARS-CoV-2 emerged in Wuhan…
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