grant
Project 3: Defining adaptive immune interactions that shape Clostridioides difficile infection
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Mar 2023Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY2025AcuteAgeAnimal ModelAnimal Models and Related StudiesAnimalsAntibodiesAntibody ResponseAutomobile DrivingB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBindingBlood SerumC diffC difficileC. diffC. diff vaccineC. difficileC. difficile vaccineCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCell BodyCell DifferentiationCell Differentiation processCell Surface ProteinsCellsCharacteristicsChildhoodChronic PhaseClinicalClostridioides difficileClostridioides difficile vaccineClostridium difficileClostridium difficile vaccineDNADataDefectDeoxyribonucleic AcidDiseaseDisorderElderlyEngineeringFecesFeedbackFiltrationFiltration FractionationFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryGene TranscriptionGenerationsGenetic TranscriptionGoalsHelper CellsHelper T-CellsHelper T-LymphocytesHelper-Inducer T-CellsHelper-Inducer T-LymphocyteHumanImmuneImmune EvasionImmune PrecipitationImmune TargetingImmune memoryImmune responseImmune systemImmunesImmunityImmunocompetentImmunodeficient MouseImmunologic MemoryImmunological MemoryImmunoprecipitationImpairmentIn SituIn VitroInducer CellsInducer T-LymphocytesInfectionInnate ImmunityIntestinalIntestinal MucosaIntestinesLarge IntestineMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMemory B CellMemory B-LymphocyteMessenger RNAMiceMice MammalsMicroscopyModern ManMolecular InteractionMucosal ImmunityMucous body substanceMucusMurineMusNative ImmunityNatural ImmunityNon-Specific ImmunityNonspecific ImmunityPathogenicity FactorsPathway interactionsPatientsPhysiologyPopulationPrimary InfectionRNA ExpressionRNA SeqRNA sequencingRNA vaccineRNA-based vaccineRNAseqRag1Rag1 MouseRecurrenceRecurrentReportingResolutionRiskSamplingSerumSeverity of illnessShapesSterilitySystemT4 CellsT4 LymphocytesToxinTranscriptionTransmissionVaccinatedVaccination acquired immunityVaccination induced immunityVaccine Clinical TrialVaccine DesignVaccinesVirulence FactorsVisualizationadaptive immune responseadaptive immunityadult youthadvanced ageage associatedage correlatedage dependentage linkedage relatedage specificaged miceaged mouseagesanamnestic reactionbowelcellular differentiationdevelop a vaccinedevelop vaccinesdevelopment of a vaccinedisease severitydisparate effectdisparate impactdisparate resultdraining lymph nodedrivingelderly miceexperiencefecal microbial transplantationfecal microbiome transplantationfecal microbiota transplantfecal microbiota transplantationfecal transplantfecal transplantationflow cytophotometrygeriatricglobal gene expressionglobal transcription profilehigh dimensionalityhigh riskhigh risk grouphigh risk individualhigh risk peoplehigh risk populationhost responseimmune competentimmune evasiveimmune system responseimmunoresponsein vivoinequitable effectinequitable impactinequitable outcomeinfection recurrencelarge bowelmRNAmRNA vaccinemRNA-based vaccinemetagenome sequencingmetagenomic sequencingmicrobialmodel of animalmucousnon vaccinatednot vaccinatedold miceoutcome disparitiesoutcome inequalityoutcome inequitypathogenpathwaypatient populationpediatricpressurepreventpreventingprimary end pointprimary endpointrecurrent infectionrecurring infectionregional lymph noderesolutionsresponsesecondary immune responsesenior citizensterilestoolsuccesstranscriptometranscriptome sequencingtranscriptomic sequencingtransmission processunequal effectunequal impactunequal outcomeunvaccinatedvaccination studyvaccination trialvaccine acquired immunityvaccine associated immunityvaccine candidatevaccine developmentvaccine responsevaccine responsivenessvaccine studyvaccine trialvaccine-induced immunityvaccine-induced protectionvaccine-induced responsevaccines against C . Difficilevaccines against Clostridioides difficileyoung adultyoung adult ageyoung adulthood
Description preview
SUMMARY: PROJECT 3 - IMMUNOLOGY
The quality of the host immune response to Clostridioides difficile infection is one of the strongest predictors of
disease severity. Despite the protective capacity of the host immune response, the immune parameters that
promote immunity remain poorly understood. Approximately 25-35% of patients that recover from…
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