grant
Project 2 - Imaging of Brain Connrectivity, Structure and Function
Organization UNIVERSITY OF SOUTHERN CALIFORNIALocation Los Angeles, UNITED STATESPosted 30 Sept 2016Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY2025AD dementiaAPOEAPOE e3APOE e4APOE-ε4APOEε4AccelerationAdventitial CellAffectAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's biomarkerAlzheimer's disease biological markerAlzheimer's disease riskAlzheimers DementiaAlzheimer’s biological markerAlzheimer’s disease biomarkerAmentiaAmmon HornAmyloidAmyloid SubstanceApo-EApoE proteinApolipoprotein EArteriosclerotic DementiaAttentionBBB disruptionBiological MarkersBlood - brain barrier anatomyBlood Coagulation Factor IBlood Coagulation Factor OneBlood Factor OneBlood VesselsBlood brain barrier dysfunctionBlood-Brain BarrierBrainBrain Nervous SystemBrain VascularBrain Vascular DisordersBrain imagingCLG4BCerebrovascular CirculationCerebrovascular DiseaseCerebrovascular DisordersClinicalCoagulation Factor ICoagulation Factor OneCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCornu AmmonisDataDementiaDisturbance in cognitionDysfunctionEncephalonEnrollmentFactor IFactor OneFibrinogenFunctional MRIFunctional Magnetic Resonance ImagingFunctional disorderFunding OpportunitiesGELBGenesGenetic predisposing factorGyrus HippocampiGyrus ParahippocampalisHemato-Encephalic BarrierHippocampal GyrusHippocampusHomozygoteImageImpaired cognitionImpairmentIndividualInjuryInstructionIntracranial Vascular DiseasesIntracranial Vascular DisordersLate Onset Alzheimer DiseaseLongitudinal StudiesMMP9MMP9 geneMR ImagingMR TomographyMRIMRIsMT-bound tauMagnetic Resonance ImagingMapsMediatingMediationMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMemoryMethodologyNMR ImagingNMR TomographyNegotiatingNegotiationNuclear Magnetic Resonance ImagingPETPET ScanPET imagingPETSCANPETTParahippocampal GyrusParticipantPathway interactionsPericapillary CellPericytesPerivascular CellPersonsPhysiopathologyPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrimary Senile Degenerative DementiaProceduresProtocolProtocols documentationRad.-PETReceptor ProteinReportingResearchRestRiskRoleRouget CellsShapesSpecific qualifier valueSpecifiedStagingStructureTauopathiesTestingTimeVascular DementiaZeugmatographyabnormally aggregated tau proteinalzheimer riskamyloid pathologyanalyzing longitudinalapo E-3apo E-4apo E3apo E4apo epsilon4apoE epsilon 4apoE-3apoE-4apoE3apoE4apolipoprotein E epsilon 4apolipoprotein E-3apolipoprotein E-4apolipoprotein E3apolipoprotein E4bio-markersbiologic markerbiomarkerblood flow in brainblood-brain barrier disruptionbloodbrain barrierbloodbrain barrier disruptionbrain blood circulationbrain blood flowbrain vascular diseasebrain vascular dysfunctionbrain visualizationcerebral blood flowcerebral circulationcerebral vascularcerebral vascular diseasecerebral vascular dysfunctioncerebro-vascularcerebrocirculationcerebrovascularcerebrovascular blood flowcerebrovascular contributions to dementiacerebrovascular dysfunctioncognitive assessmentcognitive dysfunctioncognitive functioncognitive losscognitive testingdementia riskenrollfMRIfilamentous tau inclusiongenetic risk factorgray matterhippocampalimaginginherited factorinjuriesintracranial vascular dysfunctionlate onset alzheimerlong-term studylongitudinal analysislongitudinal outcome studiesmicrotubule associated protein tau aggregationmicrotubule associated protein tau depositmicrotubule bound taumicrotubule-bound taumild cognitive disordermild cognitive impairmentmulti-modalitymultimodalityneural imagingneuro-imagingneuro-vascularneuro-vascular unitneuroimagingneurological imagingneuropathologic tauneuropathological tauneurovascularneurovascular unitnew markernovel biomarkernovel markerolder adultolder adulthoodpaired helical filament of taupathophysiologypathwaypositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographypre-clinicalpreclinicalprimary degenerative dementiareceptorrisk factor for dementiarisk for dementiaself-aggregate tausenile dementia of the Alzheimer typesocial rolesubstantia albasubstantia griseatautau PHFtau Proteinstau accumulationtau aggregatetau aggregationtau associated neurodegenerationtau associated neurodegenerative processtau driven neurodegenerationtau factortau fibrillizationtau filamenttau induced degenerationtau induced neurodegenerationtau mediated neurodegenerationtau neurodegenerative diseasetau neurofibrillary tangletau neuropathologytau oligomertau paired helical filamenttau pathologytau pathophysiologytau polymerizationtau proteinopathytau related neurodegenerationtau-induced pathologytau-tau interactiontauopathic neurodegenerative disordertauopathyvascularvascular contributions in dementiavascular contributions to dementiavascular related dementiawhite matterτ Proteinsτ aggregation
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Project 2 – Project Summary / Abstract
Alzheimer’s disease (AD) is the most common cause of cognitive impairment in older adults and affects
over 5.8 million people in the US alone. Individuals who carry the apolipoprotein E-ε4 (APOE4) gene are at
heightened risk for developing late onset AD. Project 2 of the proposed P01 renewal “Vascular…
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