grant
Project 2: Epigenetic, Behavioral, and Physiological Outcomes in a Mouse ART Model
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 May 2011Deadline 31 May 2028
NIHUS FederalResearch GrantFY20250-11 years oldAbnormal placentationAccountingAddressAdverse effectsAgeAngelman SyndromeAssayAssisted Reproduction TechnologyAssisted Reproductive TechnologyAtmosphereBeckwith syndromeBeckwith-Wiedemann SyndromeBehavioralBioassayBiologic ModelsBiological AssayBiological ModelsBirthBirth DefectsBlastosphereCannot achieve a pregnancyCardiac DiseasesCardiac DisordersCells Placenta-TissueChildChild YouthChildren (0-21)ChromatinChromatin StructureConceptusCongenital AbnormalityCongenital Anatomical AbnormalityCongenital DefectsCongenital DeformityCongenital MalformationCouplesDNADNA MethylationDataDeoxyribonucleic AcidDevelopmentDifficulty conceivingDiseaseDisorderEffectivenessEmbryoEmbryo DevelopmentEmbryo TransferEmbryogenesisEmbryonicEmbryonic DevelopmentEnvironmentEnvironmental ExposureEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessExhibitsExomphalos-Macroglossia-Gigantism SyndromeExperimental DesignsFecundabilityFecundityFertilityFertilization in VitroFetal Body WeightFetal WeightFetusFundingGametesGene Action RegulationGene Expression RegulationGene RegulationGene Regulation ProcessGeneralized GrowthGenesGerm CellsGerm-Line CellsGestationGoalsGrowthHappy Puppet SyndromeHealthHeart DiseasesHistonesHormonalHumanIatrogenesisIndividualInfertilityInterventionLow Birth Weight InfantMarriageMaternal AgeMediatingMetabolicMetabolic DiseasesMetabolic DisorderMiceMice MammalsModel SystemModelingModern ManModificationMolecularMorphologyMurineMusNormal PlacentomaNormal RangeNormal ValuesO elementO2 elementOocytesOutcomeOvocytesOxygenParturitionPatientsPatternPhenotypePhysiologicPhysiologicalPhysiologyPlacentaPlacenta DiseasesPlacenta DisordersPlacenta Embryonic TissuePlacental DevelopmentPlacental DiseasesPlacentationPlacentomePregnancyPreimplantation DiagnosisPreimplantation EmbryoPreimplantation Genetic DiagnosisPreimplantation genetic testingPreimplantation testingProceduresProteinsPuppet ChildrenRepetitive ElementRepetitive RegionsRepetitive SequenceReproductionReproductive CellsResearchRiskRoleSafetySex CellTest-Tube FertilizationTestingTherapeuticThesaurismosisTissue GrowthValidationWeightWiedemann syndromeWiedemann-Beckwith-Combs syndromeWorkadverse consequenceadverse outcomeage at pregnancyagesassistive reproductive technologyblastocystblastuladevelopmentaleggembryo cryopreservationembryo cultureembryo freezingembryo transplantationembryonic cryopreservationembryonic freezingepigeneticallyexomphalos-macroglossia-gigantism (EMG) syndromeexperienceexperimentexperimental researchexperimental studyexperimentsfallsfamilial macroglossia-omphalocele syndromefertility assistancefertility cessationfertility interventionsfertility lossfertility treatmentfetalgenetic resultsgenetic testing resultsgenome scalegenome-widegenomewideheart disorderhistone demethylasehuman dataiatrogeniciatrogenicallyiatrogenicityimprintimprovedin vivoinfertileinfertility treatmentinitial cellinsightintercalationkidslow birth weightlow birthweightmacroglossia-omphalocele syndromemacroglossia-omphalocele-visceromegaly syndromemetabolism disordermouse modelmurine modeloffspringolder womenontogenyplacenta morphologyplacental disordersplacental morphologypostnatalpre-implantation embryopuppetlike syndromesex dimorphismsexual cellsexual dimorphismsexually dimorphicsocial rolesuccesstechnology interventiontechnology-based interventionstechnology-enabled interventionstechnology-focused interventionsvalidationsweightsyoungster
Description preview
Abstract
Assisted Reproductive Technologies (ART) are invaluable for the increasing number individuals who require
interventions to treat their infertility. Nevertheless, ART-conceived children are at increased risk for loss-of-
imprinting disorders, e.g., Angelman Syndrome, resulting from epigenetic errors, as well as placental disorders,…
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