grant
Project 2 - Convergence of innate immunity and microbial communities in the regulation of anti-blood group antibody development
Organization BRIGHAM AND WOMEN'S HOSPITALLocation BOSTON, UNITED STATESPosted 1 Aug 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY2025ABH Blood GroupABO blood group systemABO blood groupsABO(H) blood groupsAb responseAntibodiesAntibody FormationAntibody ProductionAntibody RepertoireAntigensB blood cellsB cellB cellsB-CellsB-LymphocytesB-cellBindingBlood Group AntigensBlood GroupingBlood TypingBlood erythrocyteBlood typing procedureCarbohydratesCell surfaceCessation of lifeClinicalClinical ResearchClinical StudyCommunitiesCoupledD-Galactoside-Binding LectinDataDeathDevelopmentErythrocyte TransfusionErythrocytesErythrocyticExposure toFamily memberGalactose Binding LectinGalaptinsGalectinsGlycansH Blood GroupH Blood Group SystemImmuneImmunesImmunityImmunochemical ImmunologicImmunologicImmunologic FactorsImmunologicalImmunological FactorsImmunologicallyImmunologicsIn VitroIndividualInnate ImmunityIntestinal MucosaKO miceKnock-out MiceKnockout MiceLifeLipopolysaccharidesMarrow erythrocyteMediatingMedicineMiceMice MammalsMicrobeModelingMolecular InteractionMurineMusNative ImmunityNatural ImmunityNon-Specific ImmunityNonspecific ImmunityNull MouseOutcomePolysaccharidesPre-Clinical ModelPreclinical ModelsProteinsRed Blood Cell TransfusionRed Blood CellsRed CellRegulationRoleS-Type LectinsSeriesShapesSourceSpecificitySurfaceTestingTransfusionTransplantationanti-microbialantibody biosynthesisantimicrobialbeta-D-Galactosyl-Specific Lectinbeta-Galactoside Binding Lectinblood corpusclesblood groupclinical relevanceclinically relevantcommunity microbesconditional knock-outconditional knockoutdevelopmentalhuman subjectimmunogenimmunoglobulin biosynthesisimmunologic substanceimmunological substancein vivoinhibitorinsightmicrobe communitymicrobialmicrobial communitymicrobial consortiamicrobial floramicrobiotamicrofloramicroorganism communitymultispecies consortianew approachesnovel approachesnovel strategiesnovel strategypolymicrobial communitypre-clinical studypreclinical studypreventpreventingsocial roletransplant
Description preview
Project 2 SUMMARY: Anti-ABO(H) antibodies, which form spontaneously within the first few months of life,
represent the most common immunological barrier to transfusion and transplantation. However, these antibodies
can vary widely between individuals, with significant differences in the levels and specificity of anti-ABO(H)
antibodies that have…
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