grant

Project 1: Virtual Reality to Support Cognitive Health and Engagement and Socialization Among Aging Adults

Organization WEILL MEDICAL COLL OF CORNELL UNIVLocation NEW YORK, UNITED STATESPosted 15 Jun 2022Deadline 31 May 2027
NIHUS FederalResearch GrantFY202521+ years oldAD dementiaAD related dementiaADRDAdultAdult HumanAgingAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAlzheimers DementiaAreaAttitudeCOVID crisisCOVID epidemicCOVID pandemicCOVID-19 crisisCOVID-19 epidemicCOVID-19 eraCOVID-19 global health crisisCOVID-19 global pandemicCOVID-19 health crisisCOVID-19 pandemicCOVID-19 periodCOVID-19 public health crisisCOVID-19 yearsCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCommunicationControlled StudyCreativenessDataDevelopmentDisturbance in cognitionEducationEducational aspectsEmotionalEnhancement TechnologyEthnic OriginEthnicityEvaluationExposure toFocus GroupsFosteringGuidelinesHealthHealth CareHomeImmersionImpaired cognitionIndividual DifferencesInstructionInvestigatorsLifeLinkLonelinessMarketingMeasuresMediatingMediatorMedical RehabilitationModelingMuseumsNational Institutes of HealthOutcomeParticipantPersonal SatisfactionPhasePhysical FunctionPopulationPopulation HeterogeneityPrimary Senile Degenerative DementiaProtocolProtocols documentationQOLQuality of lifeRandomization trialRandomizedRehabilitationRehabilitation therapyResearchResearch PersonnelResearch ResourcesResearchersResourcesRiskSARS-CoV-2 epidemicSARS-CoV-2 global health crisisSARS-CoV-2 global pandemicSARS-CoV-2 pandemicSARS-coronavirus-2 epidemicSARS-coronavirus-2 pandemicSafetySamplingServicesSevere Acute Respiratory Syndrome CoV 2 epidemicSevere Acute Respiratory Syndrome CoV 2 pandemicSevere acute respiratory syndrome coronavirus 2 epidemicSevere acute respiratory syndrome coronavirus 2 pandemicSiteSocial InteractionSocial isolationSocial supportSocializationSystemTabletsTechnologyTestingTimeTrainingUnited States National Institutes of Healthadulthoodaged groupaged groupsaged individualaged individualsaged peopleaged personaged personsaged populationaged populationsaging and technologyaging populationcognitive abilitycognitive dysfunctioncognitive losscognitive rehabcognitive rehabilitationcoronavirus disease 2019 crisiscoronavirus disease 2019 epidemiccoronavirus disease 2019 global health crisiscoronavirus disease 2019 global pandemiccoronavirus disease 2019 health crisiscoronavirus disease 2019 pandemiccoronavirus disease 2019 public health crisiscoronavirus disease crisiscoronavirus disease epidemiccoronavirus disease pandemiccoronavirus disease-19 global pandemiccoronavirus disease-19 pandemiccreativitycybersicknessdeath riskdesigndesigningdevelop therapydevelopmentaldiverse populationsevidence baseexperienceheterogeneous populationheuristicshomesimmersive digital environmentimmersive environmentimmersive virtual environmentimmersive virtual realityimpressionimprovedinformation gatheringinnovateinnovationinnovativeintervention developmentlonelymild cognitive disordermild cognitive impairmentmortality riskolder adultolder adulthoodphase 1 designsphase I designspopulation agingpopulation diversitypreferencepreventpreventingprimary degenerative dementiaprogramsrandomisationrandomizationrandomized trialrandomly assignedrehab therapyrehabilitativerehabilitative therapysenile dementia of the Alzheimer typesevere acute respiratory syndrome coronavirus 2 global health crisissevere acute respiratory syndrome coronavirus 2 global pandemicsocialsocial engagementsocial involvementsocial participationsocial support networkstructured datatech developmenttechnology developmenttherapy developmenttreatment developmentusabilityvirtualvirtual realityvirtual reality environmentvirtual reality interventionvirtual reality systemvirtual reality-based interventionvirtual technologywell-beingwellbeing
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Full Description

Project Summary
Maintaining cognitive health has become a topic of increased importance with population aging, given the

criticality of cognition to quality of life and independence. Unfortunately, changes in life circumstances, health

declines, and other factors such as mobility limitations, limit opportunities for cognitive, social and activity

engagement for older adults, all of which are important to cognitive health. Virtual reality (VR) systems have

evolved, are more powerful and accessible to consumers, and present unique opportunities to foster cognitive

and social engagement among older adults in their own homes. VR systems provide an immersive and engaging

experience that give users the realistic impression of being present in a context or situation outside their home,

alone or with others. Despite the significant potential of VR, few studies have examined usability and acceptance

of VR applications or their efficacy with older adults. Further, most studies of VR involving older adults have

targeted physical functioning or cognitive rehabilitation; few have examined social or cognitive engagement

applications. Both researchers and system developers underscore the need for more rigorous research in this

area with adequate control conditions, across a wider range of VR applications, and with larger, diverse samples

of older adult populations in home settings. This highly innovative cross-site Stage 1 Intervention Development

Project (NIH Stage Model) [18] will apply the CREATE systematic approach to the design and evaluation of an

immersive VR program, Cognitive Activity Social Technology (CAST), for older adults. The program will provide a

suite of virtual cognitive, social and activity engagement applications; and allow for virtual interactions. Phase I,

akin to NIH Stage 1a [18], will involve focus groups and usability testing across the three CREATE sites with

older adults, and heuristic analysis to gather information on user preferences, usability problems, implementation,

and training protocols. Phase II, akin to NIH Stage 1b, will involve a cross-site pilot randomized trial with a large

and diverse sample of aging adults (N =216). Participants will be randomized, following a baseline assessment,

to the VR CAST condition or a table control condition, where participants will be exposed to similar context in 2d

(e.g., online museum tours). Following training on the VR program/tablet, they will use the VR program/tablet in

their home for two months. The battery of measures will be re-administered at 1 and 2-months post

randomization. The battery will include demographic and technology experience, attitudes, and proficiency

measures; measures of usability, safety/comfort, perceived usefulness, enjoyment, and measures of cognitive

abilities, social connectivity, loneliness, well-being, and quality of life. VR participants will also complete

measures of “presence” and cybersickness. We will collect real time data on use of the VR program/tablet. The

planned project represents one of the largest and most rigorously controlled study on the topic to date. It will yield

significant and timely information on the feasibility of using VR support for older adults, delineate potential

mediator and moderators of the benefits of VR, and design guidelines for VR interventions for older adults.

Grant Number: 5P01AG073090-04
NIH Institute/Center: NIH

Principal Investigator: Neil Charness

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