grant
Project 1. Type 2 diabetes, APOC3 and cardiovascular disease
Organization UNIVERSITY OF WASHINGTONLocation SEATTLE, UNITED STATESPosted 15 Aug 2020Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY2025ASCVDAddressAdult-Onset Diabetes MellitusAdverse effectsAffectAntigenic DeterminantsApolipoproteinsArterial Fatty StreakArteriesAtheromaAtheromatousAtheromatous degenerationAtheromatous plaqueAtherosclerosisAtherosclerotic Cardiovascular DiseaseBindingBinding DeterminantsBlood PlasmaBlood SerumBody TissuesBrittle Diabetes MellitusCITE sequencingCITE-seqCITEseqCardiovascularCardiovascular Body SystemCardiovascular DiseasesCardiovascular Organ SystemCardiovascular systemCell BodyCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell ProtectionCell SignalingCell surfaceCellsCellular FunctionCellular Indexing of Transcriptomes and Epitopes by SequencingCellular PhysiologyCellular ProcessCleaved cellClinical TrialsCollaborationsComplementComplement ProteinsCytoprotectionD-GlucoseDataDextroseDiabetes MellitusDiabetic mouseDisintegrinsEndothelial CellsEnhancersEpitopesEventFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFundingGlucoseGoalsHeart VascularHepaticHepatic CellsHepatic Parenchymal CellHepatocyteHomolog of Drosophila TOLLHumanIDDMImpairmentIndividualInflammatoryInsulin-Dependent Diabetes MellitusIntracellular Communication and SignalingJuvenile-Onset Diabetes MellitusKetosis-Prone Diabetes MellitusKetosis-Resistant Diabetes MellitusKineticsLDL CholesterolLDL Cholesterol LipoproteinsLeiomyocyteLengthLesionLinkLipid BindingLipidsLipoproteinsLiverLiver CellsLow Density Lipoprotein CholesterolMacrophageMaturity-Onset Diabetes MellitusMeasuresMediatingMetallopeptidasesMetalloproteasesMetalloproteinasesMethodsMiceMice MammalsModelingModern ManMolecular InteractionMurineMusMyelogenousMyeloidMyeloid CellsMφNIDDMNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusOutcomePathway interactionsPersonsPlasmaPlasma SerumPlayPopulationPrebeta-LipoproteinsPrediabetesPrediabetes syndromePrediabetic StatePredicting RiskProductionProspective StudiesProteinsReceptor ProteinReticuloendothelial System, Serum, PlasmaRiskRisk FactorsRoleSerumServicesSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSlow-Onset Diabetes MellitusSmooth Muscle CellsSmooth Muscle MyocytesSmooth Muscle Tissue CellStable Diabetes MellitusSubcellular ProcessSudden-Onset Diabetes MellitusT1 DMT1 diabetesT1DT1DMT2 DMT2DT2DMTLR4TLR4 geneTREM2TREM2 geneTissuesToll HomologueTriacylglycerolTriggering Receptor Expressed in Myeloid Cells 2Triggering Receptor Expressed on Myeloid Cells 2Triglyceride MetabolismTriglyceridesType 1 Diabetes MellitusType 1 diabetesType 2 Diabetes MellitusType 2 diabetesType I Diabetes MellitusType II Diabetes MellitusType II diabetesVLDLVLDL LipoproteinsVariantVariationVery low density lipoproteinadult onset diabetesatheromatosisatherosclerosis plaqueatherosclerotic diseaseatherosclerotic lesionsatherosclerotic plaqueatherosclerotic vascular diseasebeta-Lipoprotein Cholesterolbiological signal transductionblood glucose regulationcardiovascular disease riskcardiovascular disordercardiovascular disorder riskcellular indexing of transcriptomes and epitopes by single cell sequencingcirculatory systemcohortcomplementationcoronary artery calciumcoronary calciumcytoprotectivediabetesdiabetes mouse modelexperimentexperimental researchexperimental studyexperimentsextracellularflow cytophotometryforecasting riskglobal gene expressionglobal transcription profileglucose controlglucose homeostasisglucose regulationglycemic controlhepatic body systemhepatic organ systemindexinginsightinsulin dependent diabetesinsulin dependent type 1juvenile diabetesjuvenile diabetes mellitusketosis prone diabetesketosis resistant diabeteslipid boundmaturity onset diabetesmouse modelmurine modelnovelparticlepathwayplaques in atherosclerosispre-diabetespre-diabeticprediabeticpredict riskpredict riskspredicted riskpredicted riskspredicting riskspredictive riskpredicts riskprematureprematuritypreventpreventingreceptorrisk predictionrisk predictionsscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolestable isotopetherapeutic targettoll-like receptor 4transcriptometranscriptomicstranslational studytype 1 and type 2 diabetestype 2 DMtype I and type II diabetestype I diabetestype II DMtype one diabetestype two diabetesuptake
Description preview
Project 1 Abstract:
People with type 1 diabetes (T1D) or type 2 diabetes (T2D) are at greatly increased risk of premature
atherosclerotic cardiovascular disease (CVD). The increased risk of CVD in individuals with diabetes is due in
part to factors distinct from glucose and LDL-cholesterol and is linked to abnormal metabolism of triglyceride-
rich…
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