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Project 1 Title: Gut microbial metabolites as drivers of ethanol-induced liver injury
Organization CLEVELAND CLINIC LERNER COM-CWRULocation CLEVELAND, UNITED STATESPosted 1 May 2016Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY2025Absolute ethanolAddressAlcohol Chemical ClassAlcohol DrinkingAlcohol abuseAlcohol consumptionAlcoholic Fatty LiverAlcoholic Liver DiseasesAlcoholsAminesAutoregulationBody TissuesCancersCardiovascular DiseasesCarnitineCell Communication and SignalingCell SignalingCholineCholine GlycerophospholipidsCholine PhosphoglyceridesChronic Kidney FailureChronic Renal DiseaseChronic Renal FailureChronotherapyCircadian DysregulationCircadian RhythmsCommunicationCuesDataDevelopmentDiabetes MellitusDietDiseaseDisorderDrug TargetingETOHEnvironmentEnvironmental FactorEnvironmental Risk FactorEnzyme AntagonistEnzyme GeneEnzyme InhibitorEnzyme Inhibitor AgentEnzyme Inhibitor DrugsEnzymesEtOH abuseEtOH drinkingEtOH useEthanolEthyl AlcoholFK506 Binding Protein 12-Rapamycin Associated Protein 1FKBP12 Rapamycin Complex Associated Protein 1FMO3FRAP1FRAP1 geneFRAP2FatsFatty acid glycerol estersFecesFoodFundingG Protein-Complex ReceptorG Protein-Coupled Receptor GenesG-Protein-Coupled ReceptorsGI microbiomeGPCRGenomeGerm-FreeGrain AlcoholGrantHepaticHepatic DisorderHomeostasisHomo sapiensHumanHuman FigureHuman bodyInjury to LiverIntestinalIntestinesIntracellular Communication and SignalingInvestigatorsKnowledgeL CarnitineLecithinLevocarnitineLinkLiverLiver diseasesLyaseLyase GeneMalignant NeoplasmsMalignant TumorMechanistic Target of RapamycinMethylcarbinolMiceMice MammalsMicrobeMicronutrientsModern ManMurineMusMuscle AtrophyMuscular AtrophyMutateNIAAANational Institute on Alcohol Abuse and AlcoholismNutrientNyctohemeral RhythmObesityOrganismOxidesPathogenesisPathway interactionsPatientsPeripheralPhosphatidylcholinesPhysiological HomeostasisProductionR24RAFT1Receptor ProteinResearch PersonnelResearchersSignal TransductionSignal Transduction SystemsSignalingTestingTherapeuticTimeTissuesTransmissionTransplantationTwenty-Four Hour RhythmVitamin B Tadiposityalcohol co-abusealcohol induced hepatic injuryalcohol induced liver disorderalcohol induced liver injuryalcohol ingestionalcohol intakealcohol problemalcohol product usealcohol related liver diseasealcohol usealcohol-associated liver diseasealcohol-induced hepatic dysfunctionalcohol-induced liver diseasealcohol-induced liver dysfunctionalcohol-mediated liver dysfunctionalcohol-mediated liver injuryalcohol-related liver diseasealcoholic beverage consumptionalcoholic drink intakealcoholic liver injuryaminebiobankbiological signal transductionbiorepositorybowelcardiovascular disorderchronic kidney diseasecircadiancircadian abnormalitycircadian clockcircadian disruptioncircadian disturbancecircadian dysfunctioncircadian impairmentcircadian pacemakercircadian processcircadian rhythmicitycohortcommensal communitycommensal microbiomecommensal speciescorpulencedaily biorhythmdevelopmentaldiabetesdietsdigestive tract microbiomeenteric microbiomeenvironmental riskethanol abuseethanol consumptionethanol drinkingethanol induced hepatic injuryethanol induced liver disorderethanol induced liver injuryethanol ingestionethanol intakeethanol liver diseaseethanol product useethanol useethanol-induced hepatic dysfunctionethanol-induced liver diseaseethanol-induced liver dysfunctionethanol-mediated liver dysfunctionethanol-mediated liver injuryfatty liver diseaseflavin-containing monooxygenase 3gastrointestinal microbiomegut microbesgut microbial speciesgut microbiomegut-associated microbiomehazardous alcohol usehepatic body systemhepatic damagehepatic diseasehepatic injuryhepatic organ systemhepatopathyhost microbiotahost microflorahuman diseaseinhibitorinjury to tissueintegrated circuitintegrated circuitsintestinal biomeintestinal microbesintestinal microbiomeliver damageliver developmentliver disorderliver injuryliving systemmTORmalignancymammalian target of rapamycinmicrobialmicrobiome communitymouse modelmurine modelmuscle breakdownmuscle degradationmuscle deteriorationmuscle lossmuscle wastingmutantneoplasm/cancernon-alcohol fatty livernon-alcoholic fatty livernonalcohol fatty livernonalcoholic fatty liverpathwaypharmacologicproblem alcohol useproblem drinkingproblematic alcohol consumptionproblematic alcohol usereceptorresident commensalsresident microbesresident microflorasarcopeniasarcopenicskeletal muscle atrophyskeletal muscle breakdownskeletal muscle lossskeletal muscle metabolismskeletal muscle protein lossskeletal muscle protein metabolismskeletal muscle wastingsmall moleculestoolsymbionttissue injurytransmission processtransplant
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ABSTRACT
Recent evidence has emerged that microbes resident in the human intestine represent a key transmissible
environmental factor contributing to a number of human diseases. However, mechanisms by which gut
microbial-derived factors signal to the host to promote these diseases are largely unknown. We have recently
discovered a metaorganismal…
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