grant
Project 1: Rational design of targeted vaccines to induce HIV V2-apex bnAb responses
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 17 Jul 2025Deadline 31 May 2030
NIHUS FederalResearch GrantFY2025AIDS VirusAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency Syndrome VirusAddressAffinityAnimal ModelAnimal Models and Related StudiesAntibodiesAntibody AffinityAntibody ResponseAntigenic DeterminantsAntigensApicalApplications GrantsB blood cellsB cellB cell receptorB cellsB-Cell Antigen ReceptorB-CellsB-LymphocytesB-cellBindingBinding DeterminantsBiologyCell LineageClinical EvaluationClinical TestingCollaborationsConsensusDevelopmentDirected Molecular EvolutionElementsEngineeringEpitopesEvaluationExclusionExhibitsFailureFrequenciesGametesGerm CellsGerm LinesGerm-Line CellsGlycansGoalsGrant ProposalsHIVHIV envelopeHIV envelope proteinHIV vaccineHIV-1HIV-1 vaccineHIV-IHIV/AIDS VaccinesHIV1HIV1 vaccineHumanHuman Immunodeficiency Virus Type 1Human Immunodeficiency VirusesHuman immunodeficiency virus 1Ig Somatic HypermutationImmunizationImmunoglobulin Gene RearrangementImmunoglobulin Somatic HypermutationIn VitroInfectionKI miceKnock-in MouseLAV-HTLV-IIILaboratoriesLeadLymphadenopathy-Associated VirusM mulattaM. mulattaMacaca mulattaMacaca rhesusMessenger RNAMethodsModelingModern ManMolecularMolecular ConfigurationMolecular ConformationMolecular InteractionMolecular StereochemistryMonkeysNHP modelsNeedlesPb elementPeptidesPolishesPolysaccharidesPropertyReagentRegimenReproductive CellsResearch DesignRhesusRhesus MacaqueRhesus MonkeySHIVSchemeScienceSex CellSiteStructureStudy TypeSurfaceT cell responseTestingTimeTranslatingVaccinationVaccine DesignVaccine ResearchVaccinesVariantVariationVirus ReplicationVirus-HIVWorkantigen antibody affinitybasebaseschallenge in rhesus macaquesclinical testconformationconformationalconformational stateconformationallyconformationsdesigndesigningdevelop a vaccinedevelop vaccinesdevelopment of a vaccinedevelopmentaldirected evolutionevaluate vaccinesheavy metal Pbheavy metal leadhuman immunodeficiency virus vaccineimmunogenin vivoinfected rhesus macaquesinfected rhesus monkeyinfection in rhesus macaquesinfection of rhesus macaquesinitial cellinnovateinnovationinnovativeinsightknockin micelipid based nanoparticlelipid nanoparticlemRNAmanufacturemodel of animalnano particlenano-sized particlenanoparticlenanosized particleneutralizing antibodynon-human primatenonhuman primatenonhuman primate modelsnovelpre-clinicalpre-clinical trialpreclinicalpreclinical trialpreventpreventingrational designresearch clinical testingresponserhesus challengerhesus macaque challengerhesus monkey infectionsexual cellsimian HIVsimian human immunodeficiency virussomatic hypermutationstudy designsuccesstoolvaccination protocolvaccine antibodiesvaccine developmentvaccine evaluationvaccine induced antibodiesvaccine platformvaccine protocolvaccine screeningvaccine strategyvaccine testingvaccine-induced antibodiesvaccine-related researchviral multiplicationviral replicationvirus multiplication
Get Agency plan to apply$29.99/mo · 7-day free trial · pipeline · alerts
or
— or —Get email alerts for similar roles
Description preview
SUMMARY/ABSTRACT: (Project 1)
Developing an effective HIV vaccine remains a formidable challenge. Previous approaches focused on
stimulating protective T cell responses, non-neutralizing antibodies or broadly neutralizing antibodies (bnAbs).
Unfortunately, all these strategies have fallen short in providing consistent protection against infection…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click