grant
Project 1 - Molecular and cellular determinants of hematopoietic clonal expansion
Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 7 Apr 2017Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2025AgeAssayBar CodesBehaviorBioassayBiological AssayBlood CellsBlood Precursor CellCell BodyCell CompartmentationCell CompartmentationsCellsClonal ExpansionClonal expansion of hematopoietic cellsClonal expansion of hematopoietic stem cellsClonal hematopoietic expansionDNA methyltransferase 3 alpha mutationDNA mutationDNMT3aDNMT3a mutationDataEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEventExhibitsGenesGenetic ChangeGenetic defectGenetic mutationGenetic studyGenomicsGenotypeGrantHSC subsetsHematologic Body SystemHematologic CancerHematologic MalignanciesHematologic NeoplasmsHematologic Organ SystemHematological MalignanciesHematological NeoplasmsHematological TumorHematologyHematopoiesisHematopoieticHematopoietic Body SystemHematopoietic CancerHematopoietic Cellular Control MechanismsHematopoietic Progenitor CellsHematopoietic Stem Cell subsetsHematopoietic SystemHematopoietic progenitor subsetsHematopoietic stem cellsHeterogeneityHumanIn VitroIndividualInduced DNA AlterationInduced MutationInduced Sequence AlterationLineage TracingMalignant Hematologic NeoplasmMapsModelingModern ManMolecularMonitorMultipotent Stem CellsMutationPatient MonitoringPatientsPenetrancePeripheral Blood CellPhenotypePhysiologicPhysiologicalPopulationPrevalenceProcessProductionProgenitor CellsResolutionRoleTechnologyWorkagesbarcodeblood cell formationblood cell progenitorblood progenitorblood stem cellblood-forming stem cellcell lineage analysiscell lineage mappingcell lineage tracingcell lineage trackingcellular lineage mappingcellular lineage trackingclonal expansions in the bloodclonal hematopoiesisclones in hematopoietic cellsepigenetic regulationepigeneticallyfunctional outcomesgenome mutationgenomic toolshDNA methyltransferase 3ahematopoietic cell cloneshematopoietic progenitorhematopoietic stem cell clonalityhematopoietic stem progenitor cellhemopoietichemopoietic progenitorhemopoietic stem cellin vivoinsightmouse modelmultipotent progenitormultipotent progenitor cellmurine modelmutantnovelpermissivenessprogramsresolutionsresponseself-renewself-renewalsocial rolestemstem cellstool
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PROJECT SUMMARY
The human hematopoietic system is maintained by a pool of hundreds of thousands self-renewing
hematopoietic stem cells and multipotent progenitor cells. Recently, large genetic studies have revealed
the prevalence of somatic, clonal mutations, in blood cells of healthy individuals, a process referred as
clonal hematopoiesis (CH).…
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