grant
Project 1: Mechanisms of Early Disease Progression in FPF
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 17 Sept 2024Deadline 31 Jul 2029
NIHUS FederalResearch GrantFY20251st degree relativeActive Follow-upAddressAffectAgeAge YearsAutomobile DrivingB-Cell SubsetsB-Lymphocyte SubsetsBiologicalBiological MarkersBiopsyBloodBlood Reticuloendothelial SystemBlood monocyteBronchioalveolar LavageBronchoalveolar LavageBronchopulmonary LavageBronchoscopyCAT scanCD14CD14 geneCT X RayCT XrayCT imagingCT scanCategoriesCell BodyCellsCharacteristicsChronologyClinicalCohort StudiesComputed TomographyConcurrent StudiesCytokine Signal TransductionCytokine SignalingDNA MethylationDataDevelopmentDiseaseDisease ProgressionDisorderEnrollmentEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEpigenetic ageExpression SignatureFirst Degree RelativeFrequenciesGene Expression ProfileGeneral PopulationGeneral PublicGeneticGenetic PredispositionGenetic Predisposition to DiseaseGenetic RiskGenetic SusceptibilityGenetic propensityGenotypeGrowth AgentsGrowth FactorGrowth SubstancesHigh Resolution Computed TomographyImageImmuneImmunesIndividualInherited PredispositionInherited SusceptibilityInstructionKnowledgeLengthLungLung LavageLung Respiratory SystemLung Tissue FibrosisLymphatic cellLymphocyteLymphocyticMarrow monocyteMeasuresPBMCPatientsPeripheral Blood Mononuclear CellPhenotypePopulationPredictive ValuePrevalenceProteins Growth FactorsPulmonary FibrosisRadiographyResearchRiskRisk-associated variantRoentgenographyScanningSignal PathwaySpecificityT-CellsT-LymphocyteTestingTomodensitometryX-Ray CAT ScanX-Ray Computed TomographyX-Ray Computerized TomographyXray CAT scanXray Computed TomographyXray computerized tomographyactive followupagesbio-markersbiologicbiologic markerbiomarkerbronchiolar alveolar lavagebronchopulmonary lavage therapycatscanclinical developmentclinical diagnosiscohortcomputed axial tomographycomputer based predictioncomputer tomographycomputerized axial tomographycomputerized tomographydata integrationdevelopmentaldrivingenrollepigeneticallyfibrosis in the lungfollow upfollow-upfollowed upfollowupgene expression patterngene expression signaturegenetic etiologygenetic mechanism of diseasegenetic vulnerabilitygenetically predisposedhigh resolution CTimagingimprovedinterstitialkindredlung fibrosislymph cellmethylation patternmonocytenon-contrast CTnoncontrast CTnoncontrast computed tomographypre-clinicalpre-clinical studypreclinicalpreclinical studypredictive biological markerpredictive biomarkerspredictive markerpredictive modelingpredictive molecular biomarkerprogramsradiological imagingrisk allelerisk generisk genotyperisk locirisk locusrisk variantscRNA sequencingscRNA-seqscreeningscreeningssingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingtelomerethymus derived lymphocytetranscriptional profiletranscriptional signaturetranscriptome profilingtranscriptomic profilingtranscriptomics
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PROJECT SUMMARY
Although there has been substantial progress over the past decade in deciphering the pathobiology of
progressive pulmonary fibrosis (PF), a large knowledge gap exists regarding the pre-clinical stages of the
disease. To address this need, we propose to leverage our ongoing cohort study of asymptomatic relatives of
patients with…
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