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Project 1: Mechanisms, Dynamics, and Prediction of Heteroresistance

Organization EMORY UNIVERSITYLocation ATLANTA, UNITED STATESPosted 5 Mar 2021Deadline 28 Feb 2026 ⚠️
NIHUS FederalResearch GrantFY2025A baumanniA baumanniiA. baumanniA. baumanniiA.baumanniiAcinetobacter baumanniAcinetobacter baumanniiAcuteAddressAerobacterAfter CareAfter-TreatmentAftercareAlgorithmsAnimalsAntibiotic AgentsAntibiotic DrugsAntibiotic ResistanceAntibiotic TherapyAntibiotic TreatmentAntibioticsBackBacteriaBacteria resistanceBacteria resistantBacterial resistantBiologicalCell BodyCell Communication and SignalingCell SignalingCellsClinicalClinical MicrobiologyClinical ResearchClinical StudyColiform BacilliCollectionCopy Number PolymorphismDataDetectionDorsumDrugsE coliE. coliEnteric BacteriaEnterobacterEnterobacteriaEnterobacteriaceaeEscherichia coliEvolutionExhibitsFrequenciesGene AmplificationGenerationsGenesGeneticGenomeGram-Negative BacteriaHeteroresistanceHeteroresistantIn VitroInfectionInterdisciplinary ResearchInterdisciplinary StudyIntermediate resistanceIntermediate resistantIntracellular Communication and SignalingK pneumoniaeK. pneumoniaeKlebsiella pneumoniaeMath ModelsMedicationMiscellaneous AntibioticModelingMultidisciplinary CollaborationMultidisciplinary ResearchPap TestPap screeningPap smearPapanicolaou SmearPapanicolaou TestPharmaceutical PreparationsPhenotypePhysiologicPhysiologicalPopulationPopulation AnalysisPredispositionProcessPropertyR-Series Research ProjectsR01 MechanismR01 ProgramResearch GrantsResearch Project GrantsResearch ProjectsResistanceResistance to antibioticsResistant to antibioticsSEQ-ANSequence AnalysesSequence AnalysisSignal TransductionSignal Transduction SystemsSignalingSusceptibilitySwedenTreatment FailureTreatment outcomeWorkantibiotic drug resistanceantibiotic resistantbacteria classificationbacterial disease treatmentbacterial infectious disease treatmentbacterial resistancebehavior influencebehavioral influencebiologicbiological signal transductionclinical relevanceclinically relevantcombatcopy number variantcopy number variationcostdesigndesigningdrug/agentefflux pumpentire genomeexperimentexperimental researchexperimental studyexperimentsfitnessfull genomegene testinggene-based testinggenetic analysisgenetic testinggenome sequencingimprovedinfection recurrencemathematic modelmathematical modelmathematical modelingnatural gene amplificationnew approachesnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel approachesnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel strategiesnovel strategynovel therapeuticsnovel therapypost treatmentpressurerecurrent infectionrecurring infectionresistance generesistance locusresistance mechanismresistance to Bacteriaresistance to Bacterialresistantresistant generesistant mechanismresistant to Bacteriaresistant to Bacterialscreeningscreeningstherapy failuretooltraitwhole genome

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Description preview

ABSTRACT
Understanding antibiotic resistance mechanisms is critical to designing novel approaches and therapeutics to
combat resistant bacteria. Heteroresistance (HR) is a bacterial phenotype in which an isolate contains a
subpopulation of cells that show a substantial increase in antibiotic resistance compared to the main population.
Many species…

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Project 1: Mechanisms, Dynamics, and Prediction of Heteroresistance — EMORY UNIVERSITY | UNITED STATES | Mar 2021 | Dev Procure