grant
PROJECT 1: IMMUNE MEMORY
NIHUS FederalResearch GrantFY20252019 novel corona virus2019 novel coronavirus2019-nCoVAntibody ResponseAntigensBMCELLTYBindingBiostatistics CoreBlood Plasma CellBlood SampleBlood specimenBone MarrowBone Marrow AspirationBone Marrow CellularityBone Marrow Reticuloendothelial SystemBooster ImmunizationCD4 CellsCD4 Positive T LymphocytesCD4 T cellsCD4 helper T cellCD4 lymphocyteCD4+ T-LymphocyteCD4-Positive LymphocytesCD8CD8 CellCD8 T cellsCD8 lymphocyteCD8+ T cellCD8+ T-LymphocyteCD8-Positive LymphocytesCD8-Positive T-LymphocytesCD8BCD8B1CD8B1 geneCOVID infected patientCOVID patientCOVID positive patientCOVID-19COVID-19 infected patientCOVID-19 infectionCOVID-19 patientCOVID-19 positive patientCOVID-19 virusCOVID-19 virus infectionCOVID19 infectionCOVID19 patientCOVID19 positive patientCOVID19 virusCV-19Cancer CenterCell DifferentiationCell Differentiation processCell Mediated ImmunologyCell-Mediated ImmunityCellular ImmunityClinicalCoV-2CoV2CollaborationsCoronavirus Infectious Disease 2019EpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEvolutionGene TranscriptionGenetic TranscriptionGenomicsGoalsHumanHumoral ImmunitiesImmune memoryImmunityImmunologic MemoryImmunological MemoryImmunologyIndividualInfectionInnate ImmunityInstitutionInvestigatorsKnowledgeLYT3Length of LifeLong-term cohortLongevityLongitudinal cohortMemoryMemory B CellMemory B-LymphocyteModern ManMolecularMolecular InteractionMucosaMucosal TissueMucous MembraneNative ImmunityNatural ImmunityNon-Specific ImmunityNonspecific ImmunityPatientsPhenotypePlasma CellsPlasmacytesPost-vaccination infectionRNA ExpressionRNA vaccineRNA-based vaccineResearch PersonnelResearchersSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV-2 infected patientSARS-CoV-2 infectionSARS-CoV-2 patientSARS-CoV-2 positive patientSARS-CoV2SARS-CoV2 infectionSARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2SamplingSecondary ImmunizationSevere Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome related corona virus 2T cell differentiationT-CellsT-LymphocyteT4 CellsT4 LymphocytesT8 CellsT8 LymphocytesTimeTranscriptionUniversitiesVaccinationVaccinesViral DiseasesVirusVirus DiseasesWuhan coronavirusadaptive immune responseagedanamnestic reactionantibody-based immunitybooster dosebooster shotbooster vaccinationbooster vaccinebreakthrough infectioncellular differentiationclinical research siteclinical sitecohortcoronavirus disease 2019coronavirus disease 2019 infected patientcoronavirus disease 2019 infectioncoronavirus disease 2019 patientcoronavirus disease 2019 positive patientcoronavirus disease 2019 viruscoronavirus disease infected patientcoronavirus disease patientcoronavirus disease positive patientcoronavirus disease-19coronavirus disease-19 patientcoronavirus disease-19 viruscoronavirus infectious disease-19coronavirus patientepigeneticallyexperiencehCoV19immune senescenceimmunization strategyimmunogenimmunosenescenceinfected with COVID-19infected with COVID19infected with SARS-CoV-2infected with SARS-CoV2infected with coronavirus disease 2019infected with severe acute respiratory syndrome coronavirus 2insightmRNA vaccinemRNA-based vaccinememory CD4 T cellmemory CD4 T lymphocytenCoV2neutralizing antibodypatient infected with COVIDpatient infected with COVID-19patient infected with SARS-CoV-2patient infected with coronavirus diseasepatient infected with coronavirus disease 2019patient infected with severe acute respiratory syndrome coronavirus 2patient with COVIDpatient with COVID-19patient with COVID19patient with SARS-CoV-2patient with coronavirus diseasepatient with coronavirus disease 2019patient with severe acute respiratory distress syndrome coronavirus 2plasmocyteprogramsrecruitresponsesecondary immune responsesevere acute respiratory syndrome coronavirus 2 infected patientsevere acute respiratory syndrome coronavirus 2 patientsevere acute respiratory syndrome coronavirus 2 positive patientsuccessthymus derived lymphocytetranslational studyvaccination strategyvaccine boostvariants of concernviral infectionvirus infectionvirus-induced disease
Description preview
Our long-term goal is to understand the cellular and molecular basis of immunological memory in humans. We
will address this important question in Project 1 by doing a detailed analysis of both humoral and cellular immunity
in a longitudinal cohort of over > 700 COVID-19 patients that we have been following for the past three years
and will now…
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