grant

Project 1: Genetic Discovery Within Diverse Ancestry Cohorts

Organization UNIVERSITY OF MIAMI SCHOOL OF MEDICINELocation CORAL GABLES, UNITED STATESPosted 1 Jul 2022Deadline 30 Jun 2027
NIHUS FederalResearch GrantFY2025AD dementiaAD modelAccountingAddressAfricanAfrican AmericanAfrican American groupAfrican American individualAfrican American peopleAfrican American populationAfrican AmericansAfrican CaribbeanAfro AmericanAfro-CaribbeanAfroamericanAgingAllelesAllelomorphsAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer risk factorAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimer's disease modelAlzheimer's disease riskAlzheimers DementiaAmericanBiologicalBiological MarkersBody TissuesCaribbean HispanicCell BodyCellsChromosomesCodeCoding SystemCommunitiesComplexCustomDataData CollectionData Management CoreDegenerative Neurologic DisordersDisparitiesDisparityEconomicsEnrollmentEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEthnic GroupEthnic PeopleEthnic PopulationEthnic individualEthnicity PeopleEthnicity PopulationGWA studyGWASGene variantGenesGeneticGenetic DiversityGenetic VariationGenetic predisposing factorGenomicsGenotypeGoalsHealth PolicyHeritabilityHispanicLatineLatinxLatinx groupLatinx individualLatinx peopleLatinx populationLocalized DiseaseMethodsModelingMolecularNervous System Degenerative DiseasesNetwork AnalysisNeural Degenerative DiseasesNeural degenerative DisordersNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNon-HispanicNonhispanicNot Hispanic or LatinoParticipantPathway AnalysisPathway interactionsPhenotypePopulationPopulation HeterogeneityPrimary Senile Degenerative DementiaPublic HealthRacial GroupRegulatory ElementResearch ResourcesResourcesRiskRisk FactorsSample SizeSamplingSiteStandardizationStatistical Data AnalysesStatistical Data AnalysisStatistical Data InterpretationTOPMedTestingTissuesTrans-Omics for Precision MedicineVariantVariationadjudicationadjudicative process and procedureallelic variantalzheimer modelalzheimer riskbio-markersbiologicbiologic markerbiomarkerblack Caribbeanblack caribclinical practicecohortcomputer based predictioncustomsdata management and coordinating centerdata management centerdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdisparity in healthdiverse populationseconomicenrollepigeneticallyethnic subgroupethnicity groupgene testinggene-based testinggenetic architecturegenetic risk factorgenetic testinggenetic variantgenome scalegenome wide associationgenome wide association scangenome wide association studygenome-widegenomewidegenomewide association scangenomewide association studygenomic variantglobal gene expressionglobal transcription profilehealth care policyhealth disparityheterogeneous populationimprovedinherited factormulti-ethnicmultiethnicneurodegenerative illnessnoveloutreachpathwaypopulation diversitypredictive modelingprimary degenerative dementiaracial populationracial subgrouprecruitsenile dementia of the Alzheimer typesocialstatistical analysistranscriptomewhole genome association analysiswhole genome association study
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Full Description

PROJECT SUMMARY
The genomics of Alzheimer Disease is complex and evidence to date suggests that different ancestry groups
have distinct genetic factors that influence risk. In this project, we will perform multiple statistical analyses of
generated genetic data in African American, African, and Hispanic/Latinx populations to identify genetic factors
that are distinct within those groups. We will develop and apply new methods for identifying regulatory elements
and leveraging admixed chromosomes that are features of these populations. Finally, we will summarize results
through polygenic and pathway analyses to identify specific molecular mechanisms that harbor genetic variants
influence Alzheimer risk in each of these populations.

Grant Number: 5U19AG074865-04
NIH Institute/Center: NIH
Principal Investigator: William Bush

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