grant
Project 1: Epigenetic control of cell identity and inflammation in aging
Organization UNIVERSITY OF PENNSYLVANIALocation PHILADELPHIA, UNITED STATESPosted 1 Feb 2026Deadline 31 Jan 2031
NIHUS FederalResearch GrantFY2026AddressAffectAgeAgingAutophagocytosisBindingBody TissuesCancrum OrisCell BodyCell Communication and SignalingCell Growth and MaintenanceCell MaintenanceCell NucleusCell Nucleus Active TransportCell SignalingCellsChaperoneCharacteristicsChromatinCollaborationsComplexCytoplasmDNA ReplicationDNA SynthesisDNA biosynthesisDepositDepositionDown-RegulationDysfunctionElementsEnhancersEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessFibrosisFunctional disorderGangrenous StomatitisGene ExpressionGene TranscriptionGenesGenetic TranscriptionGenome MappingsHNF4HNF4-AlphaHNF4AHNF4A geneHepatic CellsHepatic Parenchymal CellHepatocyteHepatocyte Nuclear Factor 4-AlphaHepatocyte Nuclear Factor, 4HistologicHistologicallyHistone H3.3HistonesImmuneImmunesImmunoglobulin Enhancer-Binding ProteinInflammationInflammatoryInterphase CellIntracellular Communication and SignalingKnowledgeLife CycleLife Cycle StagesLiverLiver CellsLiver DysfunctionMediatingMetabolicMiceMice MammalsMolecularMolecular ChaperonesMolecular InteractionMurineMusNF-kBNF-kappa BNF-kappaBNFKBNomaNon-dividing CellNondividing CellNuclear Factor kappa BNuclear Transcription Factor NF-kBNuclear TransportNucleocytoplasmic ShuttlingNucleosomesNucleusOxidation-ReductionPML nuclear bodiesPathway interactionsPhenotypePhysiopathologyPredispositionProteinsRNA ExpressionRapamuneRapamycinRedoxRegulationRegulatory ElementResting CellRoleRouteSignal TransductionSignal Transduction SystemsSignalingSirolimusStimulator of Interferon GenesSusceptibilityTCF14TestingTissuesTranscriptionTranscription Factor 14, Hepatic Nuclear FactorTranscription Factor NF-kBUpregulationVariantVariationage associatedage associated diseaseage associated disorderage associated impairmentage correlatedage dependentage dependent diseaseage dependent disorderage dependent impairmentage linkedage relatedage related human diseaseage specificage-related diseaseage-related disorderage-related impairmentagedagesaging associatedaging induced epigenetic changeaging relatedaging-associated epigenetic changeaging-related epigenetic changeautophagybiological signal transductioncGAMP STINGcGAMP-STINGcGAMP/STINGcGAS/STINGcyclic GMP-AMP synthase/STINGepigenetic agingepigenetic mechanisms in agingepigenetic modifications in agingepigenetic regulation of agingepigeneticallyepigenomeglobal gene expressionglobal transcription profilehealthspan extending interventionhealthspan extending therapieshealthspan interventionhealthspan promoting interventionhealthspan promoting therapieshealthspan therapieshealthy aginghealthy aging interventionhealthy human aginghepatic body systemhepatic cell proliferationhepatic cellular proliferationhepatic organ systemhepatocyte cell proliferationhepatocyte cellular proliferationhepatocyte proliferationin vivointervention to promote healthy aginginterventions to improve healthspankappa B Enhancer Binding Proteinlife courselife spanlifespanliver cell proliferationliver cellular proliferationliver functionmembernovelnuclear factor kappa betanucleocytoplasmic transportoxidation reduction reactionpathophysiologypathwaypreservationprogramspromoterpromotorpromyelocytic leukemia nuclear bodiesrejuvenating interventionrejuvenation approachrejuvenation strategiesrejuvenation therapyrejuvenation treatmentsenescence and its associated secretory phenotypesenescence associated secretomesenescence associated secretory factorssenescence associated secretory pathwaysenescence associated secretory phenotypesenescence associated secretory programsenescence associated secretory proteinssenescent associated secretomesenescent associated secretory phenotypesenescent cellsenolyticssocial roletherapeutic rejuvenationtranscriptometranscriptomics
Get Agency plan to apply$29.99/mo · 7-day free trial · pipeline · alerts
or
— or —Get email alerts for similar roles
Description preview
SUMMARY
The epigenome and transcriptome determine cell identity and function. In liver, transcriptional regulator Hnf4α
contributes to hepatocyte identity. We found that aging results in decreased expression of highly expressed
Hnf4α target genes, suggestive of loss of cell identity. The cause and consequence of loss of cell identity and
whether…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click