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Project 1: Biomimetic Interactions Between Bacterial Pathogens and the Gastrointestinal Epithelium
Organization STANFORD UNIVERSITYLocation STANFORD, UNITED STATESPosted 1 Mar 2015Deadline 31 Mar 2026 ⚠️
NIHUS FederalResearch GrantFY202521+ years old3-D3-Dimensional3DAbdominal TyphusAddressAdultAdult HumanAffectAirAnimalsAntibiotic ResistanceApicalBacteriaBiological MimeticsBiomimeticsC pyloriC. pyloriCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCampylobacter pyloriCancer CauseCancer EtiologyCas nuclease technologyCell BodyCell DifferentiationCell Differentiation processCell surfaceCellsCessation of lifeChronicClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyComparative StudyConfocal MicroscopyData SetDeathDiseaseDisease ProgressionDisorderEnteric FeverEpithelial CellsEpitheliumExposure toFeedbackFinancial ManagementFundic GlandGastric Body CancerGastric CancerGastric Cardia CancerGastric Fundus CancerGastric GlandsGastric Pylorus CancerGastroduodenal UlcerGastroenteritisGene ModifiedGeneralized GrowthGenerationsGenetic ScreeningGlandGrowthGut EpitheliumH pyloriH pylori infectionH pyloryH. pyloriH. pylori infectionH. pyloryHelicobacter InfectionsHelicobacter Pylori InfectionHelicobacter pyloriHumanImaging ProceduresImaging TechnicsImaging TechniquesImmuneImmune Cell ActivationImmune responseImmune systemImmunesInfectionInflammationInflammatoryInformation DisseminationInnate Immune ResponseIntestinalIntestinesInvadedLiquid substanceLungLung Respiratory SystemM cellMalignant Gastric NeoplasmMalignant Gastric TumorMethodsModelingModern ManMolecularMucosaMucosal Immune SystemMucosal InflammationMucosal TissueMucositisMucous MembraneMucous body substanceMucusOccupational activity of managing financesOrganoidsPathogenicity FactorsPathologicPathway interactionsPeptic UlcerPeptic Ulcer DiseasePersonsPopulationProgenitor CellsPublic HealthReporterReportingResearchResearch ResourcesResistanceResistance to antibioticsResistant to antibioticsResolutionResourcesRisk FactorsRoleS entericaS. entericaSalmonellaSalmonella entericaScreening procedureSideSiteStaining methodStainsStomachStomach CancerSurfaceSuspension CultureSuspension substanceSuspensionsSwimmingTechnologyTestingTherapeuticTissue EngineeringTissue GrowthTyphoidTyphoid FeverVaccinesVirulence FactorsVirusadaptive immune responseadulthoodantibiotic drug resistanceantibiotic resistantbacteria pathogenbacterial pathogenbioengineered tissuebowelcellular differentiationcolonization resistancedissemination of resultsengineered tissuefluidgastricgastric malignancygastric organoidsgastric progenitorgastric stem cellgastroidgastrointestinalgastrointestinal epitheliumgene manipulationgene modificationgenetic manipulationgenetically manipulategenetically modifiedgenetically perturbhost responsehuman tissueimmune activationimmune system responseimmunoresponseintestinal epitheliumliquidlive cell imagelive cell imaginglive cellular imagelive cellular imagingmalignant stomach neoplasmmalignant stomach tumormucousmutantnovelontogenypathogenpathogenic bacteriapathwaypermissivenesspreservationresistantresolutionsresponsescRNA sequencingscRNA-seqscreening toolssingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolesocio-economicsocio-economicallysocioeconomicallysocioeconomicsstem cellsstomach fundus cancerstomach organoidstomach progenitorstomach pylorus cancerstomach stem cellsynergismtargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmentthree dimensionaltool developmentvaccine strategy
Applications closed.
Description preview
PROJECT SUMMARY (Project 1)
Helicobacter pylori and Salmonella enterica serovar Typhi (Typhi) are both strictly human-adapted pathogens
that colonize the stomach and intestine and are major public health threats worldwide that disproportionally affect
populations with lower socioeconomic resources. H. pylori chronically infects over 50% of the…
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