grant
Project 1
Organization UNIVERSITY OF FLORIDALocation GAINESVILLE, UNITED STATESPosted 30 Sept 1997Deadline 31 May 2028
NIHUS FederalResearch GrantFY2025Acinar CellAciner CellsAddressAffectAmylasesAntibodiesAntidiabetic HormoneAreaArginineAssayAutoantibodiesAutoimmune DiseasesB220B9 endocrine pancreasBeta CellBioassayBiological AssayBloodBlood Reticuloendothelial SystemBlood VesselsBody TissuesBrittle Diabetes MellitusCD45CITE sequencingCITE-seqCITEseqCarbacholCarbacholineCarbocholineCell BodyCell Communication and SignalingCell FractionCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular Immune FunctionCellular Indexing of Transcriptomes and Epitopes by SequencingCellular PhysiologyCellular ProcessCellular StressCellular Stress ResponseCollaborationsCytometryD-GlucoseDataDefectDetectionDeteriorationDextroseDiabetes MellitusDiastaseDiseaseDisorderDissociationDysfunctionEndocrineEndocrine Gland SecretionEndocrine PancreasEnzyme GeneEnzymesEventExocrine pancreasExtravasationFailureFlow CytofluorometriesFlow CytofluorometryFlow CytometryFlow MicrofluorimetryFlow MicrofluorometryFrequenciesFunctional disorderFundingGP180Gene ExpressionGlucagonGlucoseGlukagonHG-FactorHormonesHumanHumulin RHyperglycemic-Glycogenolytic FactorIDDMIFNImageImmuneImmune destructionImmune infiltratesImmune mediated destructionImmune mediated therapyImmunesImmunologic ReceptorsImmunologic SubtypingImmunological ReceptorsImmunologically Directed TherapyImmunophenotypingImmunotherapeutic agentImmunotherapyIn SituIncubatedIndividualInflammationInsulinInsulin CellInsulin Secreting CellInsulin-Dependent Diabetes MellitusInterferonsInterventionIntracellular Communication and SignalingInvestigatorsIslands of LangerhansIslet CellIslets of LangerhansJuvenile-Onset Diabetes MellitusKetosis-Prone Diabetes MellitusKnowledgeL-ArginineLY5LeakageLesionLinkLipaseLobularLymph Node Reticuloendothelial SystemLymph node properLymphaticLymphatic nodesMHC ReceptorMajor Histocompatibility Complex ReceptorMapsMetadataModern ManMolecularNesidioblastsNetwork AnalysisNovolin ROligoOligonucleotidesOrganOrgan DonorPTPRCPTPRC genePancreasPancreaticPancreatic IsletsPars endocrina pancreatisPathogenesisPathogenicityPathologicPathologyPathway AnalysisPathway interactionsPeripheralPersonsPhenotypePhysiopathologyPositionPositioning AttributeProductionProinsulinProteomicsRegular InsulinReportingResearch PersonnelResearchersResidenciesResolutionRoleSamplingSeriesSignal TransductionSignal Transduction SystemsSignalingSliceSpillageStaining methodStainsStimulusSubcellular ProcessSudden-Onset Diabetes MellitusSurfaceT cell infiltrationT cell receptor repertoire sequencingT cell receptor sequencingT-Cell Antigen ReceptorsT-Cell ReceptorT-CellsT-LymphocyteT1 DMT1 diabetesT1DT1DMT200TCR repertoire sequencingTCR sequencingTCR-seqTCRseqTestingTherapeutic HormoneTimeTissue imagingTissuesTriacylglycerol HydrolaseTriacylglycerol LipaseTriacylglycerol acylhydrolaseTributyrinaseTriglyceridaseTriglyceride LipaseTriolean HydrolaseTripcellimTrypsinType 1 Diabetes MellitusType 1 diabetesType I Diabetes MellitusVariantVariationantigen-specific T cellsautoimmune antibodyautoimmune conditionautoimmune disorderautoimmunity diseaseautoreactive T cellautoreactive antibodybiological signal transductioncell stresscellular indexing of transcriptomes and epitopes by single cell sequencingdiabetesdiabetes pathogenesisdiabetogenicdisease natural historydisease riskdisorder riskexocrine pancreaticflow cytophotometryimagingimmune cell infiltrateimmune drugsimmune functionimmune receptorimmune therapeutic approachimmune therapeutic interventionsimmune therapeutic regimensimmune therapeutic strategyimmune therapyimmune-based therapeuticsimmune-based therapiesimmune-based treatmentsimmuno therapyimmunologic therapeuticsimmunotherapeuticsimmunotherapy agentimprovedinnovateinnovationinnovativeinsightinsulin dependent diabetesinsulin dependent diabetes mellitus onsetinsulin dependent type 1insulitisisletislet autoantibodyislet cell antibodyjuvenile diabetesjuvenile diabetes mellitusketosis prone diabeteslive cell imagelive cell imaginglive cellular imagelive cellular imaginglymph glandlymph nodeslymphnodesmeta datamultiomicsmultiple omicsnoveloligospanomicspathophysiologypathwaypreventpreventingprogramsresolutionsresponsescRNA sequencingscRNA-seqself reactive antibodyself-reactive T cellsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolesynergismtherapeutic agent developmenttherapeutic developmenttherapeutic targetthymus derived lymphocytetooltraffickingtranscriptomicstributyrasetype 1 diabetes onsettype I diabetestype one diabetesvascularβ-cellβ-cellsβCell
Description preview
Recent evidence put forth by our group and others suggests type 1 diabetes (T1D) pathogenesis involves a
combination of immune, islet, and acinar pancreas defects. Hence, there is a need to understand each of these
facets in concert, linking islet and acinar cell function with precise cellular composition of the insulitis lesion,
throughout T1D…
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