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Program to promote lung regeneration and block fibrosis

Organization UNIVERSITY OF CALIFORNIA, SAN FRANCISCOLocation SAN FRANCISCO, UNITED STATESPosted 15 Feb 2020Deadline 14 Feb 2026 โš ๏ธ
NIHUS FederalResearch GrantFY2025AlveolarAnimal ModelAnimal Models and Related StudiesAttenuatedAutomobile DrivingBiopsyBody TissuesBone-Derived Transforming Growth FactorCell BodyCellsClinicClinical TrialsDataDiagnosticDimensionsDiseaseDisorderDysfunctionEGCGEGCG cpdEnvironmentEpigallocatechin GallateEpitheliumFailureFibroblastsFibrosisFunctional disorderFundingFutureGoalsGreen Tea ExtractGreen Tea PolyphenolsHealthHumanInjuryLOXL2LOXL2 geneLungLung GraftingLung Respiratory SystemLung Tissue FibrosisLung TransplantationLung fibrogenesisLung tissue regenerationLysyl Oxidase-Like 2MesenchymalMiceMice MammalsMilk Growth FactorModern ManMorbidityMorbidity - disease rateMurineMusNatural regenerationOrganoidsPathway interactionsPatientsPhysiopathologyPlatelet Transforming Growth FactorProcessProgenitor CellsPulmonary FibrosisPulmonary GraftPulmonary TransplantPulmonary TransplantationPulmonary fibrogenesisRegenerationResearchTGF BTGF-betaTGF-ฮฒTGFbetaTGFฮฒTea catechinTestingTimeTissuesTransforming Growth Factor betaTransforming Growth Factor-Beta Family GeneType II CellType II Epithelial Receptor Cellattenuateattenuatescytokinedrivingepigallocatechin-3-gallateepithelial injuryepithelial progenitorepithelial progenitor cellepithelial stem cellepithelium regenerationfibrogenesisfibrosis in the lungfibrotic lung diseasefibrotic pulmonary diseaseimprovedin vivoinhibitorinjurieslung fibrosislung regenerationlung transplantmodel of animalmolecular imagingmolecule imagingmortalitynew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathophysiologypathwayprogenitorprogramspulmonary regenerationregenerateregenerate epitheliumresilienceresilientscRNA sequencingscRNA-seqsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsmall moleculestemstem cellstissue biomarkers

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Description preview

ABSTRACT
The goal of this research program is to understand the interactions between lung epithelial and mesenchymal
cells in sufficient detail to deliver new therapeutic interventions in pulmonary fibrosis, a process without disease
modifying therapies. This program is anchored by a recently funded RO1 to further elucidate mechanisms of aโ€ฆ

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Program to promote lung regeneration and block fibrosis โ€” UNIVERSITY OF CALIFORNIA, SAN FRANCISCO | UNITED STATES | Feb | Dev Procure