grant
Progenitor Cells for High Endothelium in the Immune Response
Organization PALO ALTO VETERANS INSTIT FOR RESEARCHLocation PALO ALTO, UNITED STATESPosted 25 Sept 2017Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY2026ASCVDAddressApoptosisApoptosis PathwayAssayAtherosclerosisAtherosclerotic Cardiovascular DiseaseAtlasesAutoimmune DiseasesAutoregulationBioassayBiological AssayBloodBlood Reticuloendothelial SystemBlood Vessel ImagingBlood VesselsBlood capillariesBlood leukocyteBody TissuesCancersCapillary Endothelial CellCell BodyCell Communication and SignalingCell Fate ControlCell Fate RegulationCell FunctionCell PhysiologyCell ProcessCell SignalingCellsCellular FunctionCellular PhysiologyCellular ProcessChronicComplementComplement ProteinsCytometryDevelopmentDiseaseDisorderDown-RegulationER stressEndoplasmic ReticulumEndothelial CellsEndotheliumErgastoplasmFluorescenceGene AlterationGene ExpressionGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGene MutationGene TargetingGene TranscriptionGenerationsGenesGenetic TranscriptionGoalsGolgiGolgi ApparatusGolgi ComplexGrantGut associated lymphoid tissueHigh Endothelial VenuleHomeostasisHomingHumanImageImmuneImmune responseImmunesImmunityImmunizationImmunizeImmunomodulationIn SituInflammationInflammatoryInformaticsIntermediary MetabolismIntracellular Communication and SignalingKnowledgeLeukocytesLeukocytes Reticuloendothelial SystemLymph Node Reticuloendothelial SystemLymph node properLymphatic TissueLymphatic cellLymphatic nodesLymphocyteLymphocyticLymphoid TissueMalignant NeoplasmsMalignant TumorMarrow leukocyteMetabolic ProcessesMetabolismMethodsMiceMice MammalsModern ManMolecularMorphologyMurineMusMyelogenousMyeloidMyeloid CellsPathogenicityPathologicPathologyPathway interactionsPhenotypePhysiologicPhysiologicalPhysiological HomeostasisProgenitor CellsProgrammed Cell DeathProliferatingProteinsProteomicsRANK proteinRNA ExpressionRegulationResting progenitorRoleSecretory CellSignal TransductionSignal Transduction SystemsSignalingSiteSubcellular ProcessTNFRSF11A gene productTestingTherapeuticTissuesTranscript Expression AnalysesTranscript Expression AnalysisTranscriptionTranscriptional ControlTranscriptional RegulationTumor ImmunityUpregulationVaccinationVaccinesVenousWhite Blood CellsWhite CellXBP1XBP1 geneanalyze gene expressionangiogenesisanti-tumor immunityantitumor immunityatheromatosisatherosclerotic diseaseatherosclerotic vascular diseaseautoimmune conditionautoimmune disorderautoimmune inflammationautoimmunity diseasebiological signal transductioncancer immunitycandidate identificationcapillarycomplementationdevelopmentaldormant stem celldraining lymph nodeendonucleaseendoplasmic reticulum stressgene defectgene expression analysisgene expression assaygene functionhigh dimensionalityhost responseimagingimmune modulationimmune regulationimmune system responseimmunologic reactivity controlimmunomodulatoryimmunoregulationimmunoregulatoryimmunoresponseinactive stem cellinnovateinnovationinnovativeinsightlatent progenitorlatent stem celllymph celllymph glandlymph nodeslymphnodesmalignancymigrationmolecular phenotypemouse modelmurine modelmutant allelenano particlenano-sized particlenanoparticlenanosized particleneoplasm/cancernew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynotchnotch proteinnotch receptorsnotch-2 proteinnotch2 proteinnovelnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpathwaypostcapillary venuleprogenitorprogenitor cell homeostasisprogramsquiescent progenitorquiescent stem cellsreceptor activator of NF-kappaBrecruitregional lymph noderesponseresting stem cellrole modelscRNA sequencingscRNA-seqsegregationsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingsocial rolestem cell homeostasisstem cell quiescencestem cellstraffickingtranscriptional profilingtumorvascularvascular imagingvasculature Imagingwhite blood cellwhite blood corpuscle
Description preview
PROJECT SUMMARY
SUMMARY: High endothelial venules (HEV) are specialized portals for lymphocyte entry into lymphoid tissues
and sites of chronic inflammation from the blood. Along with flat walled postcapillary venules, they regulate
immune cell trafficking in physiologic and pathologic settings including autoimmune diseases, inflammation and…
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