grant
Profiling the alcohol-naive primate cortex to understand the functional role of epigenetics in predisposing the brain to risky alcohol use
Organization WAKE FOREST UNIVERSITY HEALTH SCIENCESLocation WINSTON-SALEM, UNITED STATESPosted 12 Sept 2025Deadline 31 Jul 2030
NIHUS FederalResearch GrantFY2025Absolute ethanolAddictive BehaviorAlcohol Chemical ClassAlcohol DrinkingAlcohol consumptionAlcoholsAlternate SplicingAlternative RNA SplicingAlternative SplicingAreaAssayAutomobile DrivingBehaviorBioassayBiologicalBiological AssayBiological MarkersBiopsyBlood PlasmaBlood SampleBlood SerumBlood specimenBody TissuesBrainBrain Nervous SystemCausalityCell BodyCell IsolationCell LineCell SegregationCell SeparationCell Separation TechnologyCellLineCellsChromosome MappingChronicCognitionCognitiveCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalCross Sectional AnalysisCross-Sectional AnalysesCross-Sectional StudiesCross-Sectional SurveyDNA MethylationDNA methylation profilingDataDecision MakingDiseaseDisease Frequency SurveysDisorderDisturbance in cognitionETOHEarly identificationEncephalonEnrollmentEpigeneticEpigenetic ChangeEpigenetic MechanismEpigenetic ProcessEtOH drinkingEtOH useEthanolEthyl AlcoholEtiologyExhibitsFemaleFluorescenceFutureGene Action RegulationGene ExpressionGene Expression RegulationGene LocalizationGene MappingGene Mapping GeneticsGene RegulationGene Regulation ProcessGene TranscriptionGenerationsGenetic TranscriptionGliaGlial CellsGlutamatesGrain AlcoholHeavy DrinkingHereditaryHeterogeneityImpaired cognitionIn VitroIndividualIndividual DifferencesInheritedKolliker's reticulumL-GlutamateLengthLifeLinkLinkage MappingM mulattaM. mulattaMacacaMacaca mulattaMacaca rhesusMacaqueMeasuresMethyl-SeqMethylSeqMethylationMethylation sequencingMethylcarbinolMolecularMolecular FingerprintingMolecular ProfilingMolecular TargetNerve CellsNerve Impulse TransmissionNerve TransmissionNerve UnitNeural CellNeurocyteNeurogliaNeuroglial CellsNeuronal DifferentiationNeuronal TransmissionNeuronsNeurophysiology - biologic functionNoiseNon-neuronal cellNonneuronal cellNuclearOligodendrocytesOligodendrocytusOligodendrogliaOligodendroglia CellPeripheralPlasmaPlasma SerumPlayPopulationPredispositionPrefrontal CortexPreventionPrimatesPrimates MammalsRNA ExpressionRNA SplicingRelapseReporterResolutionRestReticuloendothelial System, Serum, PlasmaRhesus MacaqueRhesus MonkeyRiskRisk MarkerRoleSample SizeSamplingSelf AdministeredSelf AdministrationSerumSeveritiesSingle-Nucleus SequencingSortingSplicingStrains Cell LinesSusceptibilitySynaptic plasticityTestingTimeTissuesTotal Human and Non-Human Gene MappingTranscriptTranscriptionTranscriptional ControlTranscriptional RegulationTranslatingValidationWorkalcohol exposedalcohol exposurealcohol ingestionalcohol intakealcohol misusealcohol product usealcohol riskalcohol usealcohol use disorderalcoholic beverage consumptionalcoholic drink intakeat-risk drinkingaxon signalingaxon-glial signalingaxonal signalingbehavior phenotypebehavioral phenotypingbio-markersbiologicbiologic markerbiomarkerbiomarker identificationcausationcell sortingcell typechronic EtOH drinkingchronic alcohol consumptionchronic alcohol drinkingchronic alcohol ingestionchronic alcohol usechronic ethanol consumptionchronic ethanol drinkingchronic ethanol ingestioncognitive dysfunctioncognitive functioncognitive losscognitive performancecohortcultured cell linedisease causationdrink heavilydrinkingdrivingenrollentire genomeepigeneticallyepigenome editingepigenomic editingethanol consumptionethanol drinkingethanol exposedethanol exposureethanol ingestionethanol intakeethanol misuseethanol product useethanol useethanol use disorderexcessive alcohol consumptionexcessive alcohol ingestionexcessive alcohol intakeexcessive drinkingexcessive ethanol ingestionexcitatory neuronexposed to alcoholexposed to ethanolexposure to alcoholexposure to ethanolextreme drinkingflexibilityflexiblefull genomegenetic mappinggenome scalegenome-widegenomewideglia signalingglial signalingglobal gene expressionglobal transcription profileglutamate signalingglutamatergicglutamatergic dendrodendritic synapsesglutamatergic signalingheavy alcohol usehigh risk drinkingidentification of biomarkersidentification of new biomarkersinhibitory neuroninnovateinnovationinnovativemalemarker identificationmetabolism measurementmetabolomicsmetabonomicsmethylomemethylomicsmolecular profilemolecular signaturenerve cementnerve signalingneuralneural functionneural signalingneurogenesisneuronalneuronal signalingneuropsychiatric diseaseneuropsychiatric disorderneurotransmissionperipheral bloodpersonalized health interventionpersonalized interventionpotential biological markerpotential biomarkerprecision interventionsrecruitresolutionsresponse to therapyresponse to treatmentrisk predictorrisk predictorsrisky drinkingsNuc-Seqsexsingle nucleus RNA-sequencingsingle nucleus seqsingle-nucleus RNA-seqsnRNA sequencingsnRNA-seqsocial rolesynapse functionsynaptic functiontherapeutic agent developmenttherapeutic developmenttherapeutic responsetherapy responsetooltranscriptometreatment responsetreatment responsivenessunhealthy alcohol usevalidationswhole genome♀♂
Description preview
PROJECT SUMMARY
Among the six percent of active ethanol drinkers who develop an alcohol use disorder (AUD), there is
great variability in etiology and relapse rates. Early and accurate identification of individuals at risk of developing
an AUD would facilitate effective deployment of personalized interventions. Recent evidence demonstrates that…
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