grant
Production and Validation of monoclonal antibodies to enhance rigor and reproducibility in research vertebrate animal model
Organization UNIVERSITY OF MASSACHUSETTS AMHERSTLocation HADLEY, UNITED STATESPosted 15 May 2025Deadline 30 Apr 2029
NIHUS FederalResearch GrantFY2026AmblystomaAmbystomaAmino Acid SequenceAmphibiaAmphibiansAnimal ModelAnimal Models and Related StudiesAnimalsAntibodiesAxolotlBiologic ModelsBiological ModelsBiomedical ResearchBody TissuesBostonCell IsolationCell SegregationCell SeparationCell Separation TechnologyCellular biologyClinical Treatment MoabCodeCoding SystemCommunitiesComplexDNA mutationDefectDevelopmentDiseaseDisorderEmbryoEmbryo DevelopmentEmbryogenesisEmbryonicEmbryonic DevelopmentEquipmentGene ProteinsGenesGenetic ChangeGenetic defectGenetic mutationGoalsHumanHybridomasImmune PrecipitationImmune reactionImmune systemImmunologyImmunoprecipitationIn SituInvestigatorsLiverMassachusettsMeasuresMedical ResearchMiceMice MammalsModel SystemModern ManMonoclonal AntibodiesMouse ProteinMurineMusMutationNIAIDNICHDNIDCRNIDDKNIDRNIGMSNational Institute of Allergy and Infectious DiseaseNational Institute of Child Health and Human DevelopmentNational Institute of Dental ResearchNational Institute of Dental and Craniofacial ResearchNational Institute of Diabetes and Digestive and Kidney DiseasesNational Institute of General Medical SciencesNational Institutes of HealthNatural regenerationPancreasPancreaticPhenotypePrimary Protein StructureProductionProtein Gene ProductsProteinsPublicationsQualifyingRegenerationReproducibilityResearchResearch PersonnelResearch ResourcesResearchersResourcesSalesScientific PublicationT-CellsT-LymphocyteTechnologyTestingTissuesUnited States National Institutes of HealthUniversitiesValidationVertebrate AnimalsVertebratesVisualizationWorkXenBaseXenopusXenopus Model Organism DatabaseXenopus ProteinsXenopus sp.cell biologycell sortingclawed frogdevelopmentalexperiencegenome mutationhepatic body systemhepatic organ systemimmunoreactionimprovedin vivolimb regenerationmAbsmodel of animalmodel organismmonoclonal Absmouse developmentmutantnovelprotein complexprotein expressionprotein functionprotein sequenceregeneratescreeningscreeningsthymus derived lymphocytetoolvalidationsvertebrata
Description preview
Project Summary
Animal models are critical for biomedical research. They allow us to rapidly test the importance of any
gene for development or diseases. Advances in technology now allow us to reduce or eliminate protein
expression in the entire animal or in selected tissue. Similarly, mutations in the coding sequence of a
gene associated with a…
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