grant
Probing the specificity and activity of the metazoan Integrator complex
Organization HARVARD MEDICAL SCHOOLLocation BOSTON, UNITED STATESPosted 15 Aug 2019Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025AbscissionAcuteAddressAffectAttenuatedAutomobile DrivingAutoregulationBasal Transcription FactorBasal transcription factor genesBindingBiochemicalBiochemistryBiologic ModelsBiological ChemistryBiological ModelsBiologyBlood DiseasesCancersCell BodyCell Communication and SignalingCell LineCell SignalingCellLineCellsCellular ExpansionCellular GrowthCementationChIP SequencingChIP-seqChIPseqChromatinCodeCoding SystemComplexCuesDNADNA mutationDNA-Dependent RNA Polymerase IIDataDeoxyribonucleic AcidDevelopmentDiseaseDisorderDissociationDrosophilaDrosophila genusDysfunctionElongation FactorEndoribonucleasesEnhancersExcisionExtirpationFGF-3FGF3FGF3 geneFibroblast Growth Factor 3Functional RNAFunctional disorderFundingGastric Body CancerGastric CancerGastric Cardia CancerGastric Fundus CancerGastric Pylorus CancerGene Action RegulationGene ActivationGene Down-RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGeneralized GrowthGenesGeneticGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenomic approachGrowthHBGF-3Heavy MetalsHematologic DiseasesHematological DiseaseHematological DisorderHematopoietic Cell TumorHematopoietic MalignanciesHematopoietic NeoplasmsHematopoietic Neoplasms including LymphomasHematopoietic TumorHematopoietic and Lymphoid Cell NeoplasmHematopoietic and Lymphoid NeoplasmsHepatic CancerHomeostasisHuman DevelopmentINT-2 Proto-Oncogene ProteinINT2ImmuneImmunesInflammationIntracellular Communication and SignalingJointsKinasesKnowledgeLaboratoriesLow Molecular Weight Nuclear RNAMalignant Gastric NeoplasmMalignant Gastric TumorMalignant Hematopoietic NeoplasmMalignant NeoplasmsMalignant TumorMalignant neoplasm of liverMass Photometry/Spectrum AnalysisMass SpectrometryMass SpectroscopyMass SpectrumMass Spectrum AnalysesMass Spectrum AnalysisMediatingMessenger RNAModel SystemModelingMolecular InteractionMurine Mammary Tumor Virus Integration site 2, mouseMutationNELFNerve CellsNerve UnitNeural CellNeurocyteNeurodevelopmental DisorderNeurological Development DisorderNeuronsNon-Polyadenylated RNANoncoding RNANontranslated RNANormal CellOncogene INT2Oxidative StressP-TEFbPathway interactionsPhosphatasesPhosphohydrolasesPhosphomonoesterasesPhosphoprotein PhosphatasePhosphoprotein Phosphatase-2CPhosphoprotein PhosphohydrolasePhosphoric Monoester HydrolasesPhosphorylationPhosphotransferase GenePhosphotransferasesPhysiological HomeostasisPhysiopathologyPositive Transcription Elongation Factor BPositive Transcriptional Elongation Factor BProductivityPromoter RegionsPromotor RegionsPropertyProtein Phosphatase CProtein Phosphatase GeneProtein Phosphatase-1Protein Phosphatase-2AProtein PhosphorylationProtein phosphataseProteinsProteomicsRNARNA ExpressionRNA Gene ProductsRNA Polymerase BRNA Polymerase IIRNA chemical synthesisRNA endonucleaseRNA synthesisRegulationRemovalRepressionResearchRibonucleic AcidRoleScaffolding ProteinSeriesSignal TransductionSignal Transduction SystemsSignalingSmall Molecular Weight RNASmall Nuclear RNASpecificityStomach CancerStrains Cell LinesStressSurgical RemovalSystemTestingTissue GrowthTranscriptionTranscription Factor Proto-OncogeneTranscription RepressionTranscription factor genesTranscriptional ControlTranscriptional RegulationTransphosphorylasesUntranslated RNAV-INT2 Murine Mammary Tumor Virus Integration Site Oncogene HomologWorkZinc Finger DomainZinc Finger MotifsZinc Fingersattenuateattenuatesbiological signal transductionblocking factorblood cancerblood disordercancer of bloodcancer of the bloodcell growthchromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingciliopathycontrolled releasecultured cell linedevelopmentaldevelopmental diseasedevelopmental disorderdrivingendonucleaseexperienceexperimentexperimental researchexperimental studyexperimentsfruit flyfunctional genomicsgastric malignancygene inductiongene repressiongenetic promoter elementgenetic promoter sequencegenome mutationgenomic effortgenomic strategyhuman diseaseimprovedinduction of genesinsightliver cancerliver malignancymRNAmalignancymalignant liver tumormalignant stomach neoplasmmalignant stomach tumormembermigrationnegative elongation factorneoplasm/cancerneurodevelopmental diseaseneuronalnoncodingontogenyoxidationpathophysiologypathwayphospho-proteomicsphosphoproteomicsprematureprematuritypromoterpromoter sequencepromotorprotein complexprotein expressionrecruitresectionresponsesnRNAsocial rolestemstomach fundus cancerstomach pylorus cancerstressorsynergismtat-Associated Kinasetooltranscription factortranscription terminationtranscriptomicsuRNA
Description preview
Project Summary
Precise control of gene expression in response to external signals and cues is essential for organismal
development, growth, and homeostasis. A critical step in metazoan gene regulation involves pausing
RNA polymerase II (RNAPII) in early elongation and its controlled release into productive RNA synthesis.
Pausing of RNAPII…
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