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Probing the Biophysical Basis of Large-Scale Brain Dynamics Using Simultaneous PET/fMRI and EEG/PET/fMRI

Organization MASSACHUSETTS GENERAL HOSPITALLocation BOSTON, UNITED STATESPosted 15 Aug 2020Deadline 30 Nov 2025 ⚠️
NIHUS FederalResearch GrantFY202518-FDG18F- FDG18FDG2 Fluoro 2 deoxy D glucose2-Fluoro-2-deoxyglucoseAD dementiaAddressAlzheimer Type DementiaAlzheimer disease dementiaAlzheimer sclerosisAlzheimer syndromeAlzheimer'sAlzheimer's DiseaseAlzheimers DementiaArousalAutomobile DrivingBehaviorBindingBiophysicsBlood VesselsBrainBrain MappingBrain Nervous SystemBrain regionCell Communication and SignalingCell SignalingClinicalClinical MarkersCognitionCognitiveComplexCoupledD-GlucoseDegenerative Neurologic DisordersDextroseDiseaseDisorderDissociationDopamineEEGElectroencephalogramElectroencephalographyEncephalonExhibitsFoundationsFunctional MRIFunctional Magnetic Resonance ImagingGlucoseGoalsGrantHealthHumanHydroxytyramineIntracellular Communication and SignalingInvestigatorsLengthLevarterenolLevonorepinephrineLinkMR ImagingMR TomographyMRIMRIsMagnetic Resonance ImagingMapsMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMental DepressionMental disordersMental health disordersMentorsMetabolicMethodologyModalityModern ManMolecular InteractionNMR ImagingNMR TomographyNatureNerve CellsNerve UnitNervous System Degenerative DiseasesNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurologic Degenerative ConditionsNeuromodulatorNeuronsNeurosciencesNoradrenalineNorepinephrineNuclear Magnetic Resonance ImagingOutcomePETPET ScanPET imagingPETSCANPETTPathologicPatternPhysiologyPopulationPositron Emission Tomography Medical ImagingPositron Emission Tomography ScanPositron-Emission TomographyPrimary Senile Degenerative DementiaProcessProtocolProtocols documentationPsychiatric DiseasePsychiatric DisorderRad.-PETRegulationResearchResearch PersonnelResearchersResolutionRestSamplingScanningSchizophreniaSchizophrenic DisordersSensitivity and SpecificitySeriesSignal TransductionSignal Transduction SystemsSignalingSpecificityStimulusStructureSyndromeTechniquesTimeTrainingTranslational ResearchTranslational ScienceVariantVariationVisualZeugmatographybiological signal transductionbiophysical foundationbiophysical principlesbiophysical sciencesblood oxygen level dependentblood oxygenation level dependentcareerclinical biomarkersclinical translationclinically translatableclinically useful biomarkerscognitive taskcostdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdementia praecoxdepressiondrivingfMRIfMRI/EEGfluorodeoxyglucosefunctional magnetic resonance imaging/electroencephalographyglucose metabolismhemodynamicsinnovateinnovationinnovativeinterestmental illnessmulti-modalitymultimodalityneuralneural controlneural imagingneural regulationneuro-imagingneurochemicalneurochemistryneurodegenerative illnessneuroimagingneurological imagingneuromodulationneuromodulatoryneuron componentneuronalneurophysiologicalneurophysiologyneuroregulationnovelpositron emission tomographic (PET) imagingpositron emission tomographic imagingpositron emitting tomographyprimary degenerative dementiaprogramspsychiatric illnesspsychological disorderresolutionsschizophrenicsenile dementia of the Alzheimer typesignal processingskillsstatisticsstemtooltranslation researchtranslational investigationvascularvascular componentvascular factor

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Functional magnetic resonance imaging (fMRI) has been broadly employed to map large-scale brain dynamics in healthy and diseased populations. Withal its high spatial localization and accessibility to deep brain structures, fMRI suffers from several key limitations, including its vulnerability to systemic physiology and inaccessibility to various…

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