grant
Principles of Speckle-Based Gene Regulation
Organization COLD SPRING HARBOR LABORATORYLocation COLD SPRING HARBOR, UNITED STATESPosted 5 Aug 2025Deadline 31 Jul 2028
NIHUS FederalResearch GrantFY2025AdoptedAnimalsBasal Transcription FactorBasal transcription factor genesBioinformaticsBiologic ModelsBiological ModelsCancer BiologyCell BodyCell Communication and SignalingCell Culture TechniquesCell NucleusCell SignalingCellsClear cell renal cell carcinomaCuesDNADeoxyribonucleic AcidDiseaseDisorderEuchromatinGene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenomic SegmentGenomicsImageInflammatoryIntracellular Communication and SignalingLigandsLinkMacrophageModel SystemModelingMolecularMφNeighborhoodsNeuroblastomaNon-Polyadenylated RNANuclearNucleusOutcomePatient outcomePatient-Centered OutcomesPatient-Focused OutcomesPositionPositioning AttributeProductionProteinsProteomicsQOLQuality of lifeRNARNA Gene ProductsResearchRibonucleic AcidRoleSignal PathwaySignal TransductionSignal Transduction SystemsSignalingTestingTextbooksTranscription Factor Proto-OncogeneTranscription factor genesWorkbiological signal transductionccRCCcell culturecell culturesextracellulargenome segmentgenomic regionimagingimprovedinsightnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovelnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypatient oriented outcomesprogramssocial roletooltranscription factortumor
Description preview
The cell nucleus houses different types of non-DNA substructures, called nuclear bodies. Among these,
nuclear speckles predominate. Speckles occupy ~15-30% of the nuclear volume and are present in cells
throughout our bodies. Proteins involved in different stages of RNA production are highly concentrated
within speckles, and speckles are the key…
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