grant
Preserving lung integrity and harnessing inflammation to treat vesicant-induced lung injury
Organization UNIVERSITY OF VIRGINIALocation CHARLOTTESVILLE, UNITED STATESPosted 14 Apr 2026Deadline 13 Apr 2029
NIHUS FederalResearch GrantFY2026AcuteAcute Lung InjuryAcute Pulmonary InjuryAdverse effectsAerosolsBenefits and RisksBiologyBis(beta-chloroethyl) SulfideBlood CirculationBloodstreamBody TissuesBruiseCell ComponentsCell DeathCell Death InductionCell StructureCell SurvivalCell ViabilityCell membraneCellular StructuresCessation of lifeChloraminChlorethazineChlormethineCommon Rat StrainsContusionsCytoplasmic MembraneDNA DamageDNA InjuryDataDeathDi-2-chloroethyl SulfideDichlorodiethyl SulfideDysfunctionEndothelial CellsEndotheliumEnvironmentEnvironmental ExposureEpithelial CellsEpitheliumEventExposure toFamily suidaeFibrosisFormulationFunctional disorderGene Expression MonitoringGene Expression Pattern AnalysisGene Expression ProfilingGoalsHN-2HN2Hemorrhagic ShockHourHumanInflammationInflammatoryInhalation AdministrationInhalation Drug AdministrationInhalation Route of Drug AdministrationInjuryIntravenousIschemia-Reperfusion InjuryKI miceKO miceKnock-in MouseKnock-out MiceKnockout MiceLipopolysaccharidesLungLung InflammationLung Respiratory SystemLung damageMacrophageMechlorethamineMembraneMethylchlorethamineMiceMice MammalsModelingModern ManMolecularMulticellular ProcessMurineMusMustard GasMustineMφNitrogen MustardNull MouseOxidative StressPathologicPhasePhysiologicPhysiologicalPhysiopathologyPigsPilot ProjectsPlasma MembranePlayPneumonitisProcessProductionProtein FamilyProteinsPulmonary InflammationPulmonary PathologyQuality ControlRatRats MammalsRattusRecombinantsReperfusion DamageReperfusion InjuryResearch ResourcesResistanceResourcesRespiratory Drug AdministrationRodentRodentiaRodents MammalsRoleSafetySiteStudy modelsSuidaeSulfur MustardSwineT-Cell Antigen Receptor-Interacting MoleculeT-Cell Receptor-Associated Transmembrane Adaptor 1TRAT1TRC-Interacting MoleculeTRIMTRIM GeneTherapeuticTissuesToxic effectToxicant exposureToxicitiesTranscript Expression AnalysesTranscript Expression AnalysisTransgenic MiceTranslatingTraumaTreatment EfficacyType II PneumocyteUniversitiesVesicantsWild Type MouseYellow Cross LiquidYperiteaerosolizedalveolar type II cellanalyze gene expressionassess effectivenesschloromethinecombatcommercial scale manufacturingcytokinedetermine effectivenessdetermine efficacyeffectiveness assessmenteffectiveness evaluationefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationevaluate effectivenessevaluate efficacyexamine effectivenessexamine efficacyexposure to environmental agentsexposure to environmental factorsexposure to environmental stimuliexposure to environmental substancesflu infectionflu virus infectiongene expression analysisgene expression assaygene repairin vivoinfected with fluinfected with flu virusinfected with influenzainfected with influenza virusinfluenza infectioninfluenza virus infectioninjuriesinjury and repairinjury to tissueintervention efficacyintravenous administrationknockin micelive cell imagelive cell imaginglive cellular imagelive cellular imaginglung functionlung injurylung ischemialung pathologylung preservationmanufacturing ramp-upmanufacturing scale-upmembermembrane structurenecrocytosisnovelpathophysiologypilot studyplasmalemmaporcinepreventpreventingpulmonarypulmonary damagepulmonary functionpulmonary injurypulmonary ischemiapulmonary tissue damagepulmonary tissue injuryrepairrepair functionrepairedreparative functionresistantscale up batchscale up productionsocial rolesuidtherapeutic agent developmenttherapeutic developmenttherapeutic efficacytherapy efficacytissue injurytissue repairtoxic exposuretranscriptional profilingupscale manufacturingvesicant induced lung damagevesicant induced lung injuryvesicant induced pulmonary injurieswildtype mouse
Description preview
PROJECT SUMMARY
Pulmonary exposure to adverse environments or vesicant agents can induce acute lung injury as well as
prolonged inflammation and fibrotic remodeling. Sulfur mustard (SM) and nitrogen mustard (NM) are alkylating
vesicant agents which cause extensive lung injuries. One consequence of vesicant exposure is the disruption of
the…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click