grant
Preservation of muscle function through Schwann cell regulation of motor unit expansion
Organization UNIVERSITY OF MICHIGAN AT ANN ARBORLocation ANN ARBOR, UNITED STATESPosted 20 Sept 2024Deadline 31 May 2029
NIHUS FederalResearch GrantFY202521+ years old2aR phosphoprotein I2ar peptideAccelerationAdenosine Cyclic Monophosphate-Dependent Protein KinasesAdultAdult HumanAgingAgonistAmyotrophic Lateral SclerosisAmyotrophic Lateral Sclerosis Motor Neuron DiseaseAnimal ModelAnimal Models and Related StudiesAtrophicAtrophyBioinformaticsCD44CD44 geneCell AdhesionCell Communication and SignalingCell CountCell Growth in NumberCell IsolationCell MultiplicationCell NumberCell ProliferationCell SegregationCell SeparationCell Separation TechnologyCell SignalingCellular AdhesionCellular ProliferationCompensationCritical PathsCritical PathwaysCrush InjuryCyclic AMP-Dependent Protein KinasesDataDecline in mobilityDecrease in mobilityDecreased mobilityDenervationDevelopmentDiminished mobilityDiseaseDisorderElderlyEnabling FactorsEta-1 proteinEta-1-Op proteinEventFailureFiberGehrig's DiseaseGenesGenetic ModelsGenomicsGoalsHealthImpairmentIn VitroInjuryInterventionIntracellular Communication and SignalingLinkLou Gehrig DiseaseMDU3MeasuresMediatingMedical RehabilitationMiceMice MammalsMobility declineMobility impairmentModelingMolecularMotorMotor CellMotor NeuronsMurineMusMuscleMuscle AtrophyMuscle FibersMuscle TissueMuscle WeaknessMuscle functionMuscular AtrophyMuscular WeaknessMusculoskeletalMyoneural JunctionMyotubesNerveNerve CrushNeurilemma CellNeurilemmal CellNeuromuscular JunctionOperative ProceduresOperative Surgical ProceduresPKAPKC(alpha)PKCAPKCαPRKCAPRKCA genePathway interactionsPatternPeripheral nerve injuryPgp1PhysiologicPhysiologicalPopulationPreventiveProcessProliferatingPropertyProtein Kinase AProtein Kinase C AlphaProtein Kinase C αProtein Kinase CalphaPublic HealthPublishingQOLQOL improvementQuality of lifeReceptor ProteinReduced mobilityReduction in mobilityRegulationRehabilitationRehabilitation therapyReportingRhabdomyocyteRoleSOD-1SOD-1 proteinSOD1SOD1 geneSOD1 gene productSchwann CellsSignal PathwaySignal TransductionSignal Transduction SystemsSignalingSiteSkeletal FiberSkeletal MuscleSkeletal Muscle CellSkeletal Muscle FiberSkeletal MyocytesSortingStructureSurgicalSurgical InterventionsSurgical ProcedureSynapsesSynapticTestingTimeUpregulationValidationVoluntary MuscleWild Type MouseWorkadulthoodadvanced ageage associated effectsage associated muscle atrophyage effectage related effectsage-associated decline in muscleage-associated muscle declineage-associated muscle deteriorationage-associated muscle lossage-associated muscle wastingage-related decline in muscleage-related muscle declineage-related muscle deteriorationage-related muscle lossage-related muscle wastingaged miceaged mouseaging effectaxon growthaxon growth cone guidanceaxon guidanceaxonal growthaxonal sproutingbiological signal transductionbone sialoprotein 1bone sialoprotein IcAMP-Dependent Protein Kinasescell sortingconfocal imagingdevelopmentaldisabilityearly T-lympocyte activation-1 proteinelderly miceenhance healthspanexperimentexperimental researchexperimental studyexperimentsextend healthspanextending healthy lifespanfALSfall riskfamilial ALSfamilial amyotrophic lateral sclerosisfluorescence imagingfluorescent imagingfrailtygeriatrichealthspan extensionimpact of ageimprove healthspanimprovements in QOLimprovements in quality of lifein vitro Modelin vivoin vivo Modelincrease healthspaninfluence of ageinjuriesinnervationinsightmodel of animalmotoneuronmotor impairmentmouse modelmovement impairmentmovement limitationmultidisciplinarymurine modelmuscle breakdownmuscle bulkmuscle degradationmuscle deteriorationmuscle formmuscle lossmuscle massmuscle wastingmuscularnerve cell deathnerve cell lossnerve injurynerve supplyneural injuryneurogenesisneuromuscularneuron cell deathneuron cell lossneuron deathneuron lossneuronal cell deathneuronal cell lossneuronal deathneuronal guidanceneuronal lossneutralizing antibodyold ageold miceolder menosteopontinpathwayperipheral nerve crush injuriespreservationprolong healthspanpromote healthspanprotein expressionprotein kinase Cαquality of life improvementreceptorrehab therapyrehabilitativerehabilitative therapyreinnervatereinnervationresponsesarcopeniasarcopenicscRNA sequencingscRNA-seqsecreted phosphoprotein 1senior citizensialoprotein 1single cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingskeletal muscle atrophyskeletal muscle breakdownskeletal muscle lossskeletal muscle protein lossskeletal muscle wastingsocial rolesuccessful interventionsuperoxide dismutase 1surgerysynapsetherapeutic targetvalidationswildtype mouse
Description preview
ABSTRACT. Preservation of muscle function through Schwann cell regulation of motor unit expansion
The loss of skeletal muscle mass and function with aging, known as sarcopenia, is a universal health challenge
for the growing elderly population, contributing to decreased mobility, increased disability, loss of independence,
and poor quality of…
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