grant
Prenatal PFAS Exposure and Adult Cardiometabolic Disease
Organization BROWN UNIVERSITYLocation PROVIDENCE, UNITED STATESPosted 6 Aug 2025Deadline 31 May 2029
NIHUS FederalResearch GrantFY20250-11 years old21+ years old7 year old7 years of ageActive Follow-upAddressAdipose tissueAdolescentAdolescent YouthAdultAdult HumanAdult-Onset Diabetes MellitusAdverse effectsAgeAmericanAnalytic ChemistryAnalytical ChemistryAnthropometryAttenuatedBMIBMI percentileBMI z-scoreBehavioralBindingBiologicalBiological MarkersBiometricsBiometryBiostatistical MethodsBiostatisticsBirthBirth WeightBloodBlood Reticuloendothelial SystemBlood SerumBody mass indexCardiac DiseasesCardiac DisordersCardiometabolic DiseaseCardiometabolic DisorderCardiovascular DiseasesCause of DeathChemicalsChemistryChildChild YouthChildhoodChildren (0-21)Chronologic Fetal MaturityClinicalClinical Medical SciencesClinical MedicineCommunitiesCosmeticsDataDevelopmentDevelopmental ToxicantDiabetes MellitusDietary qualityDiseaseDisorderDysfunctionDyslipidemiasEnvironmentEnvironmental EpidemiologyExposure toF elementFamily StudyFatty TissueFetal AgeFetal Growth RestrictionFetal Growth RetardationFluorineFoodFunctional disorderGeneralized GrowthGestationGestational AgeGrowthHealthHeart DiseasesHumanHydrogen OxideIUGRIndividualInfantInsulin ResistanceInterventionIntrauterine Growth RetardationJointsKetosis-Resistant Diabetes MellitusKnowledgeLeadLifeLinkLong-Term EffectsLong-term Follow-upLow Birth Weight InfantMaturity-Onset Diabetes MellitusMeasuresMediatingMetabolic syndromeModern ManMolecular InteractionNIDDMNeonatalNew EnglandNon-Insulin Dependent DiabetesNon-Insulin-Dependent Diabetes MellitusNoninsulin Dependent DiabetesNoninsulin Dependent Diabetes MellitusNortheastern United StatesObesityOilsOutcomePFASParturitionPb elementPerinatalPeripartumPhysical activityPhysiopathologyPoisonPoly-fluoroalkyl substancesPopulationPredispositionPregnancyPregnant WomenPremature BirthPrematurely deliveringPreterm BirthPreventative strategyPrevention strategyPreventive strategyProspective cohortQuetelet indexResearchResearch ResourcesResourcesRiskRisk AssessmentRisk FactorsRodentRodentiaRodents MammalsSamplingSerumSlow-Onset Diabetes MellitusStable Diabetes MellitusSusceptibilityT2 DMT2DT2DMTechniquesTextilesTissue GrowthToxic ChemicalToxic SubstanceType 2 Diabetes MellitusType 2 diabetesType II Diabetes MellitusType II diabetesUnited StatesVulnerable PopulationsWateractive followupadiposeadiposityadult onset diabetesadulthoodage 7 yearsagesattenuateattenuatesbio-markersbiologicbiologic markerbiomarkerblood pressure elevationcardiometaboliccardiometabolismcardiovascular disordercohortcorpulencecosmetic productdesigndesigningdevelopmentaldiabetesdiet qualitydrinking waterearly childhoodelevated blood pressureexpectant motherexpectant womenexpecting motherexpecting womenexposed in uterofabricfetalfetal exposurefollow upfollow-upfollowed upfollowuphealth assessmentheart disorderheavy metal Pbheavy metal leadhigh riskimpaired fetal growthin utero exposureincrease in blood pressureincreased blood pressureindividuals who are pregnantinfancyinfantileinsulin resistantinsulin toleranceintra-uterine environmental exposureintra-uterine growth restrictionintra-uterine growth retardationintrauterine environmental exposureintrauterine growth restrictionjuvenilejuvenile humanketosis resistant diabeteskidslife-style factorlifestyle factorslong-term followuplow birth weightlow birthweightmaturity onset diabetesoffspringontogenypathophysiologypediatricpeople who are pregnantperfluorinated alkyl substancesperfluoroalkyl substancesperfluoroalkylated substancespolyfluorinated alkyl substancespolyfluoroalkyl substancespostnatalpregnant femalespregnant motherspregnant peoplepregnant populationspremature childbirthpremature deliveryprenatalprenatal exposureprenatal growth disorderprenatally exposedpreterm deliveryprogramsprospectiverecruitscreeningscreeningsseven year oldseven years of agesubstance usesubstance usingsynergismthose who are pregnanttoxic compoundtype 2 DMtype II DMtype two diabetesunbornvulnerable groupvulnerable individualvulnerable peoplewhite adipose tissuewomen who are pregnantyellow adipose tissueyoungster
Description preview
Exposure to per- and polyfluoroalkyl substances (PFAS) is nearly universal in the United States (US) and has been associated with an array of adverse health outcomes in infants, children, and adults. Prior studies show that prenatal PFAS exposure may increase the risk of low birthweight, preterm birth, and altered childhood growth, which in turn…
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