grant
Prenatal Exposure to Organophosphate Ester Flame Retardants and Plasticizers (OPEs), Gene-Environment Interaction, and Child Neurodevelopment
Organization KAISER FOUNDATION RESEARCH INSTITUTELocation Oakland, UNITED STATESPosted 16 Sept 2025Deadline 30 Jun 2030
NIHUS FederalResearch GrantFY20250-11 years oldAD/HDADHDASDAffectAgeAttention deficit hyperactivity disorderAutismAutistic DisorderAwardBehavioralBiologicalBiometricsBiometryBiostatisticsCausalityChemicalsChildChild DevelopmentChild HealthChild YouthChildhoodChildren (0-21)ClinicalComplexDataDevelopmentDevelopmental ToxicantDifferences between sexesDiffers between sexesEarly Infantile AutismEndocrine DisrupterEndocrine Disrupting ChemicalsEndocrine DisruptorsEndocrine disrupting agentEnvironmentEnvironmental FactorEnvironmental Risk FactorEpidemiologic ResearchEpidemiologic StudiesEpidemiological StudiesEpidemiology ResearchEstersEtiologyExposure toFinancial costFire RetardantsFlame RetardantsGWA studyGWASGene variantGene x Environment InteractionGeneralized GrowthGenesGeneticGenetic DiversityGenetic PredispositionGenetic Predisposition to DiseaseGenetic SusceptibilityGenetic VariationGenetic predisposing factorGenetic propensityGenomeGestationGrowthGxE interactionHealthHeterogeneityHumanIndividualIndustryInfant and Child DevelopmentInfantile AutismInherited PredispositionInherited SusceptibilityInvestigationJointsKanner's SyndromeKnowledgeLifeLinkLiteratureMaternal and Child HealthMeasuresMedicalMethodsModelingModern ManModificationMothersNational Institutes of HealthNeural DevelopmentOrganophosphatesOutcomeParticipantPathway interactionsPersonsPhasePhenotypePhysiologicPhysiologicalPlasticizersPoliciesPopulationPredispositionPredominantly Hyperactive-Impulsive Type Attention-Deficit DisorderPredominantly Hyperactive-Impulsive Type Hyperactivity DisorderPregnancyPrevalenceRiskRoleSample SizeSamplingSensorySex DifferencesSexual differencesShapesSingle Base PolymorphismSingle Nucleotide PolymorphismSubgroupSumSusceptibilityTimeTissue GrowthUnited States National Institutes of HealthUrineWorkXenobiotic Metabolismagesallelic variantautism spectral disorderautism spectrum disorderautistic childrenautistic spectrum disorderbiologiccausationchildren on the autism spectrumchildren with ASDchildren with autismchildren with autism spectrum disordercohortdata resourcedecrease disabilitydecrease in disabilitydevelopmentaldisability reductiondisease causationearly in pregnancyearly pregnanciesearly pregnancyearly stage of pregnancyendocrine disrupting compoundenvironment effect on geneenvironmental chemicalenvironmental riskepidemiologic investigationepidemiology studyexposed human populationexposed in uterofetalfetal exposurefunctional genomicsgene environment interactiongenetic etiologygenetic mechanism of diseasegenetic risk factorgenetic variantgenetic vulnerabilitygenetically predisposedgenome scalegenome wide associationgenome wide association scangenome wide association studygenome-widegenomewidegenomewide association scangenomewide association studygenomic varianthigh riskhuman exposureimprovedin utero exposureinherited factorinsightintra-uterine environmental exposureintrauterine environmental exposurekidslessen disabilitymid-pregnancyminimize disabilitymitigate disabilitymonetary costneurodevelopmentneuron toxicityneuronal toxicityneurotoxicneurotoxicitynovelontogenypathwaypediatricpolybrominated biphenyl etherpolybrominated diphenyl etherpolygenic predictorspolygenic scoresprenatalprenatal exposureprenatally exposedreduction in disabilitysex based differencessex-dependent differencessex-related differencessex-specific differencessingle nucleotide variantslow disabilitysocialsocial roletooltraitunbornurinarywhole genome association analysiswhole genome association studyyoungster
Description preview
ABSTRACT
The prevalence of autism and attention-deficit/hyperactivity disorder (ADHD) is increasing, yet their etiology is
poorly understood. A complex combination of environmental and genetic factors appears to contribute to both
conditions but most studies to date have examined these factors in isolation. The incomplete study of gene-…
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