grant
Predictive modeling of CD-68 inflammatory and anti-inflammatory chromatin packing domains for personalized biomarker discovery
Organization NORTHWESTERN UNIVERSITYLocation CHICAGO, UNITED STATESPosted 1 Aug 2025Deadline 30 Apr 2030
NIHUS FederalResearch GrantFY2026(TNF)-α3-D3-Dimensional3DAddressAffectAfter CareAfter-TreatmentAftercareAmericanAnti-InflammatoriesAnti-Inflammatory AgentsAnti-Tumor Necrosis Factor TherapyAnti-inflammatoryAreaAtlasesAwardBasal Transcription FactorBasal transcription factor genesBehaviorBiologicalBiological MarkersBiological Response Modifier TherapyBiological TherapyBody TissuesCD68 antigenCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCSIFCSIF-10CachectinCancersCareer Development AwardsCareer Development Awards and ProgramsCareer Development Programs K-SeriesCas nuclease technologyCd68Cell BodyCell Communication and SignalingCell SignalingCellsChromatinChromatin AssemblyChromatin ModelingChromatin StructureChromosome 6ChronicClinicalClinical TrialsClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyColon CancerColon CarcinomaColonic DiseasesColorectal CancerComplexCytokine Signal TransductionCytokine SignalingCytokine Synthesis Inhibitory FactorDNA mutationDataDevelopmentDiseaseDisease remissionDisorderDoctor of MedicineDoctor of PhilosophyElectron MicroscopyEnhancersEnsureEquilibriumExclusionExposure toFutureGastroenterologyGene ExpressionGene TranscriptionGeneral Transcription Factor GeneGeneral Transcription FactorsGenesGenetic ChangeGenetic TranscriptionGenetic defectGenetic mutationGenomeGenomicsGoalsHepatologyHeterogeneityHistologicHistologicallyHospital AdmissionHospitalizationHospitalsIL-10IL10IL10AImageImmuneImmune DiseasesImmune DisordersImmune DysfunctionImmune System DiseasesImmune System DisorderImmune System DysfunctionImmune System and Related DisordersImmune TargetingImmune signalingImmunesImmunochemical ImmunologicImmunologicImmunologic DiseasesImmunologicalImmunological DiseasesImmunological DysfunctionImmunological System DysfunctionImmunologicallyImmunologicsImmunologyIn SituIn VitroInflammation MediatorsInflammatoryInterleukin 10 PrecursorInterleukin-10Intracellular Communication and SignalingK-AwardsK-Series Research Career ProgramsLinkM.D.MacrophageMacrophage-Derived TNFMalignant NeoplasmsMalignant TumorMeasurementMeasuresMediatingMedicalMentorshipModelingModificationMolecularMonocyte-Derived TNFMucosal InflammationMucositisMutationMyelogenousMyeloidMyeloid CellsMφNucleosomesPathway interactionsPatient CarePatient Care DeliveryPatientsPatternPersonsPh.D.PhDPhenotypePhysiciansPolymerasePolymersPopulation HeterogeneityPositionPositioning AttributePrevalenceProcessProteomicsRNA ExpressionRNA chemical synthesisRNA synthesisReactionRelapseRemissionResearch Career ProgramRoleSamplingScientistSignal PathwaySignal TransductionSignal Transduction SystemsSignalingStructureSymptom BurdenTNFTNF ATNF AlphaTNF geneTNF therapyTNF-αTNFATNFαTechnologyTestingTherapeuticTissuesTrainingTraining ProgramsTranscriptionTranscription Factor Proto-OncogeneTranscription factor genesTumor Necrosis FactorTumor Necrosis Factor TherapyTumor Necrosis Factor-alphaUlcerated ColitisUlcerative ColitisUniversitiesValidationVariantVariationWorkanti-TNF therapyanti-TNF-alpha therapybalancebalance functionbio-markersbiologicbiologic markerbiological signal transductionbiological therapeuticbiological treatmentbiologically based therapeuticsbiomarkerbiomarker developmentbiomarker discoverybiophysical modelbiotherapeuticsbiotherapycancer in the coloncare for patientscare of patientscareer developmentcaring for patientscell behaviorcell typecellular behaviorchromatin remodelingclinical investigationclinical relevanceclinically relevantcolon disordercomputer based predictioncostcytokinedebilitating symptomdevelopmentaldiverse populationsepigenetic memoryexperimentexperimental researchexperimental studyexperimentsfunctional disabilitygene interactiongene locusgenetic locusgenome mutationgenomic locationgenomic locusheterogeneous populationimagingindelindividualized biomarkersindividualized therapeuticinflammatory mediatorinsertion/deletioninsertion/deletion mutationmalignancymulti-scale computational modelingmulti-scale mathematical modelingmulti-scale modelingmultiscale computational modelingmultiscale mathematical modelingmultiscale modelingnanoneoplasm/cancernew technologynovel technologiespathwaypatient centeredpatient orientedpatient responsepatient specific responsepersonalization of treatmentpersonalized biomarkerspersonalized medicinepersonalized therapeuticpersonalized therapypersonalized treatmentpolymerpolymericpopulation diversitypost treatmentpredictive modelingpromoterpromotorresearch studyresponseresponsive patientskillssmall moleculesocial rolespatial RNA sequencingspatial gene expression analysisspatial gene expression profilingspatial integrationspatial multiomicsspatial omicsspatial resolved transcriptome sequencingspatial transcriptome analysisspatial transcriptome profilingspatial transcriptome sequencingspatial transcriptomicsspatial tri-omicsspatially resolved transcriptomicsspatio transcriptomicsthree dimensionaltraffickingtranscription factortranscriptomicstreatment strategyvalidations
Description preview
Project Summary/Abstract
Ulcerative colitis (UC) is a complex disorder impacting millions of people worldwide resulting in significant costs,
chronic debilitating symptoms, and complications such as colon cancer. Even with biologic therapies targeting
immune signaling pathways, variability in patient responses is highly prevalent and remission…
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