grant

Predictable molecular evolution during adaptation

Organization CORNELL UNIVERSITYLocation ITHACA, UNITED STATESPosted 1 Mar 2026Deadline 28 Feb 2031
NIHUS FederalResearch GrantFY2026ABC Transport ProteinABC Transporter ProteinABC TransportersATP-Binding Cassette TransportersAddressAnimalsAssayBeetlesBioassayBiological AssayBiomedical ResearchCardenolidesColeopteraComplementComplement ProteinsDistantEpistasisEpistatic DeviationEvolutionExcretory functionFliesGeneral TaxonomyGenesGeneticGenetic EpistasisGenomicsGrasshoppersInsectaInsectsInsects InvertebratesInteraction DeviationKnowledgeLepidopteraMedicalMissionModelingMolecularMolecular EvolutionNIGMSNational Institute of General Medical SciencesOrder ColeopteraOrganismOutcomePatternPhenotypePlantsPrevalenceProteinsResearchResistanceRoleShapesSystemTaxonomyTestingToxinVariantVariationWorkcomparative genomicscomplementationepistatic interactionepistatic relationshipexcretionfitnessflygene x gene interactiongenetic associationgenetic epistasesgenome editinggenomic editingin silicoliving systemmicrobialprogramsresistantsocial rolestemtranscriptomics
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Description preview

Convergent molecular evolution, especially among distantly related species, is a hallmark of
adaptation, yet the drivers of such convergence (or lack thereof) are typically unknown.

Variation in molecular convergence may stem from constraints on evolutionary trajectories, such

as how intramolecular epistasis and broader scale interactions among…

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