grant
Preclinical/Co-Clinical Section
Organization BAYLOR COLLEGE OF MEDICINELocation HOUSTON, UNITED STATESPosted 15 Sept 2020Deadline 31 Aug 2030
NIHUS FederalResearch GrantFY202521+ years oldASO therapeuticsASO therapyASO treatmentAdultAdult HumanAmericanAnimal ModelAnimal Models and Related StudiesAntisense Oligonucleotide TherapyBackBioinformaticsChildhoodClassificationClinVarClinicClinicalClinical ResearchClinical StudyClinical TrialsClinical geneticsCollaborationsCommunicationCommunitiesDNA Sequencing FacilityDNA TherapyDataData BasesDatabasesDecision MakingDevelopmentDiagnosisDiagnosticDietary InterventionDiseaseDisorderDorsumDrosophilaDrosophila genusDrosophila melanogasterGene Transfer ClinicalGenerationsGenesGeneticGenetic CounselingGenetic DiseasesGenetic InterventionGenomeGenomic medicineGenomicsGenotypeHouse miceHuman GeneticsInfrastructureInterventionIntervention StudiesInvestigatorsKO miceKnock-out MiceKnockout MiceLaboratoriesLaboratory miceLettersMedical GeneticsMedical RecordsMessenger RNAModelingMolecular GeneticsMus musculusNull MouseNutrition InterventionsNutritional InterventionsOrphan DiseaseOutcomeParticipantPathogenicityPatient CarePatient Care DeliveryPatientsPhenotypePhysiciansPre-Clinical ModelPreclinical ModelsPreventive MedicineProcessRNA SeqRNA sequencingRNAseqRare DiseasesRare DisorderRecommendationResearchResearch PersonnelResearch ResourcesResearchersResourcesReview LiteratureScientistSequencing CoreSiteSystemSystematicsTestingTranslatingTranslationsVariantVariationWorkadulthoodanti-sense oligonucleotide druganti-sense oligonucleotide therapyanti-sense oligonucleotide treatmentanti-sense therapyantisense drugantisense oligonucleotide therapeuticantisense therapeuticsantisense therapybiomarker discoverycare for patientscare of patientscaring for patientsclinical careclinical diagnosticsclinical practiceclinical research siteclinical significanceclinical siteclinically significantdata basedevelopmentaldiet interventiondiscover genesdisease modeldisorder modeldrug repositioningdrug repurposingempowermententire genomeexomeexperiencefruit flyfull genomegene discoverygene repair therapygene testinggene therapygene-based testinggene-based therapygenetic conditiongenetic consultationgenetic disordergenetic testinggenetic therapygenome analysisgenome medicinegenome sequencinggenomic therapyhuman genome sequencingintervention researchinterventional researchinterventional studyinterventions researchmRNAmedical diagnosticmodel of animalmodel organismnetwork modelsnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapeuticsnew therapynew therapy approachesnew treatment approachnew treatment strategynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapeuticsnovel therapynovel therapy approachnucleic acid therapynucleic acid-based therapeuticsoligonucleotide drugoligonucleotide therapeuticsoligonucleotide therapiesoligonucleotide treatmentorphan disorderpatient advocacy grouppediatricpersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentpre-clinicalprecision medicineprecision-based medicinepreclinicalprenatalpreventative medicineprogramsrare genetic diseaserare genetic disorderrepurposing agentrepurposing medicationscreeningscreeningssuccesssynergismtherapeutic nucleic acidstooltranscriptome sequencingtranscriptomic sequencingtranslationtranslational impactunbornunclassified variantvariant of uncertain clinical significancevariant of uncertain significancevariant of undetermined significancevariant of unknown significancewhole genome
Description preview
3. ABSTRACT - Preclinical/Co-Clinical Section (PCS)
Despite the successes of exome and whole genome sequencing in clinical practice, up to 50-70% of patients
with suspected genetic disease remain undiagnosed likely because their disease-causing gene has yet to be
discovered or because the clinical significance of variants identified in genomic…
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