grant
Preclinical Development of Oleoylethanolamide as a Medical Countermeasure for Long-Term Neurotoxicity Following Organophosphate Exposure
Organization ROSKAMP INSTITUTE, INC.Location SARASOTA, UNITED STATESPosted 20 May 2026Deadline 30 Apr 2028
NIHUS FederalResearch GrantFY202621+ years oldAcuteAddressAdultAdult HumanAfferent PathwaysAnimal ModelAnimal Models and Related StudiesAntidotesAnxietyApneaArmed Forces PersonnelArousalAutonomic DysfunctionAutonomic nervous systemBehaviorBehavior assessmentBehavioralBehavioral AssayBioavailabilityBiological AvailabilityBloodBlood Reticuloendothelial SystemBody TissuesBradycardiaBrainBrain Nervous SystemBrain StemBrain imagingBrainstemCCKCNS Nervous SystemCausalityCell BodyCell Communication and SignalingCell NucleusCell SignalingCellsCentral Nervous SystemChemical AgentsChemical ExposureChemical WarfareChemicalsChlorpyrifosCholecystokininChronicClinicalClinical TrialsCognitionCognitive DisturbanceCognitive ImpairmentCognitive declineCognitive function abnormalComplexDataDevelopmentDisturbance in cognitionDorsalDoseDrug KineticsDysfunctionEncephalonEtiologyExcretory functionExhibitsExposure toFBJ osteosarcoma oncogeneFDA approvedFOS geneFailureFatigueFiberFormulationFunctional disorderFutureG0S7GLP-1GasesGeneralized GrowthGenesGliosisGlp-1GrowthGulf WarGulf War IllnessGulf War SyndromeGut EpitheliumHarvestHistologicHistologicallyHumanHypotensionImmunohistochemistryImmunohistochemistry Cell/TissueImmunohistochemistry Staining MethodImpaired cognitionImpairmentInflammationInflammatoryIntermediary MetabolismIntoxicationIntracellular Communication and SignalingIranIraqLack of EnergyLesionLinkLipidsLow Blood PressureMeasuresMetabolic ProcessesMetabolismMiceMice MammalsMilitaryMilitary PersonnelMissionModelingModern ManMolecular AnalysisMolecular TargetMoodsMucosaMucosal TissueMucous MembraneMurineMusNational Institutes of HealthNecrosisNecroticNerveNerve CellsNerve UnitNeural CellNeuraxisNeurocyteNeuronal InjuryNeuronsNodose GanglionNucleusOperation Desert ShieldOperation Desert StormOralOral AdministrationOral Drug AdministrationOrganophosphatesOutcomePK/PDPPAR alphaPPAR-αPPARalphaPPARαPancreozyminPathologyPathway interactionsPeptidesPeroxisome Proliferator-Activated Receptor alphaPeroxisome Proliferator-Activated Receptor αPersian Gulf SyndromePesticidesPharmacodynamicsPharmacokineticsPhysiologic AvailabilityPhysiopathologyPoisonPre-Clinical ModelPreclinical ModelsPreparednessProteinsProtooncogene FOSPublic HealthRandomizedReadinessReceptor ProteinRecoveryRegulationResolutionRespiratory CenterRisk ReductionRunningSarinSecuritySignal TransductionSignal Transduction SystemsSignalingSubwaySurvivorsSyrianTerrorismTestingTherapeuticTheriacsTimeTissue GrowthTissuesTokyoToxic ChemicalToxic SubstanceToxic effectToxicitiesTranslationsUnited States National Institutes of HealthUropancreozyminVascular Hypotensive DisorderVeteransWarWorkabsorptionacute symptomadulthoodaffective disturbanceanxiety-like behaviorastrogliosisbehavior outcomebehavioral assessmentbehavioral outcomebiological signal transductionbrain visualizationc fosc-fos Genec-fos Proto-Oncogenescausationchemical attackchemical threatcholinergicclinical relevanceclinically relevantcognitive dysfunctioncognitive losscompound repositioningcompound repurposingcytokinedetermine efficacydevelopmentaldisease causationdisturbance in affectdrug repositioningdrug repurposingefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationefficacy studyevaluate efficacyexamine efficacyexcretionexperiencefield based datafield learningfield studyfield testgastrointestinal epitheliumglial activationglial cell activationglucagon-like peptide 1heart rate variabilityimaging studyimmunohistochemical biomarkersimmunohistochemical markersimprovedin vivointestinal epitheliumintraoral drug deliverymedical countermeasuremilitary populationmodel of animalmolecular biomarkermolecular markermood alterationmood and affect disturbancemood disturbancemood dysfunctionmouse modelmurine modelnerve agentnerve cell deathnerve cell lossneural inflammationneurobehavioralneuroinflammationneuroinflammatoryneuron cell deathneuron cell lossneuron deathneuron injuryneuron lossneuron toxicityneuronalneuronal cell deathneuronal cell lossneuronal deathneuronal lossneuronal toxicityneuropathologicneuropathologicalneuropathologyneuroprotectionneuroprotectiveneurotoxicneurotoxicitynew therapeutic uses for existing drugsnew use of drugnew uses for an approved drugnew uses for existing drugsoleoylethanolamideontogenyorganophosphate exposureorganophosphate poisoningpathophysiologypathwaypharmacokinetics and pharmacodynamicspharmacological repurposingpre-clinical developmentpre-clinical studypreclinical developmentpreclinical studypreventpreventingprogramsrandomisationrandomizationrandomly assignedreceptorreduce riskreduce risksreduce that riskreduce the riskreduce these risksreduces riskreduces the riskreducing riskreducing the riskrepositioning approved drugsrepositioning existing drugsrepurpose approved drugsrepurpose approved medicationrepurpose approved therapeuticrepurpose existing drugsrepurpose existing medicationrepurpose existing medicinerepurpose existing therapeuticsrepurpose existing therapiesrepurpose medicinerepurposing a drugrepurposing agentrepurposing candidatesrepurposing established drugsrepurposing established medicationrepurposing existing pharmacological agentsrepurposing medicationrepurposing of already existing drugsrepurposing pharmaceuticalsresolutionsresponserisk-reducingsample collectionspecimen collectionstandard carestandard treatmentsymptomatologyterrorist attacktherapeutic repositioningtherapeutic repurposingtoxic compoundtoxic organophosphate insecticide exposuretranslationv-FOS FBJ Murine Osteosarcoma Viral Oncogene Homolog
Description preview
Organophosphate (OP) agents, including pesticides like chlorpyrifos (CPF) and nerve agents used in warfare
or terrorism, pose a significant threat to civilian and military populations. While acute OP toxicity is attributed to
cholinergic overstimulation, growing evidence indicates that survivors often experience long-term and chronic…
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