grant
Posttranslational modifications of glucocorticoid receptor associated with drug-resistance in prostate cancer
Organization STATE UNIVERSITY OF NEW YORK AT BUFFALOLocation AMHERST, UNITED STATESPosted 9 Apr 2024Deadline 31 Mar 2029
NIHUS FederalResearch GrantFY2025AKTAKT inhibitionAKT1AKT1 geneAkt proteinAndrogen ReceptorAssayBindingBioassayBiological AssayBiological MarkersCRISPR approachCRISPR based approachCRISPR methodCRISPR methodologyCRISPR techniqueCRISPR technologyCRISPR toolsCRISPR-CAS-9CRISPR-based methodCRISPR-based techniqueCRISPR-based technologyCRISPR-based toolCRISPR/CAS approachCRISPR/Cas methodCRISPR/Cas technologyCRISPR/Cas9CRISPR/Cas9 technologyCancersCas nuclease technologyCastrate sensitive prostate cancerCell BodyCell Communication and SignalingCell DeathCell Growth in NumberCell MultiplicationCell NucleusCell ProliferationCell SignalingCell SurvivalCell ViabilityCellsCellular MorphologyCellular ProliferationChIP SequencingChIP-seqChIPseqChromatinClinical ResearchClinical StudyClinical TrialsClustered Regularly Interspaced Short Palindromic Repeats approachClustered Regularly Interspaced Short Palindromic Repeats methodClustered Regularly Interspaced Short Palindromic Repeats methodologyClustered Regularly Interspaced Short Palindromic Repeats techniqueClustered Regularly Interspaced Short Palindromic Repeats technologyDNADNA mutationDataDeoxyribonucleic AcidDiseaseDisease ProgressionDisease ResistanceDisorderDrug resistanceExposure toGIR receptorGenetic ChangeGenetic defectGenetic mutationGlucocorticoid ReceptorHormone ReceptorImmune PrecipitationImmunoprecipitationInhibition of Cell ProliferationIntracellular Communication and SignalingKnock-outKnockoutKnowledgeL-SerineLearningLigandsMalignant CellMalignant NeoplasmsMalignant TumorMalignant neoplasm of prostateMalignant prostatic tumorMediatingModelingMolecular InteractionMutationNegative Control of Cell ProliferationNegative Regulation of Cell ProliferationNuclear Hormone Receptor SuperfamilyNuclear Hormone ReceptorsNucleusOncogenicPDX modelPRKBAPatient derived xenograftPatientsPhosphorylationPhosphorylation InhibitionPhysiciansPlayPost-Translational Modification Protein/Amino Acid BiochemistryPost-Translational ModificationsPost-Translational Protein ModificationPost-Translational Protein ProcessingPosttranslational ModificationsPosttranslational Protein ProcessingProstate CAProstate CancerProstate malignancyProtein Kinase BProtein ModificationProtein PhosphorylationProteomicsProto-Oncogene Proteins c-aktPublishingRAC-ALPHARAC-ALPHA GeneRAC-PK proteinRAC-PK-AlphaReceptor ProteinReceptor SignalingResistanceResolutionRoleScientistSerineSignal PathwaySignal TransductionSignal Transduction SystemsSignalingTestingTherapeuticTherapeutic EffectTreatment EfficacyXtandiacquired treatment resistanceadvanced diseaseadvanced illnessadvanced prostate cancerandrogen ablation therapyandrogen blockade therapyandrogen dependentandrogen deprivation therapyandrogen deprivation treatmentandrogen independent prostate cancerandrogen indifferent prostate cancerandrogen insensitive prostate cancerandrogen resistance in prostate cancerandrogen resistant prostate cancerandrogen responsiveandrogen sensitiveandrogen sensitive prostate cancerantagonismantagonistanti-tumor effectantitumor effectbio-markersbiologic markerbiological signal transductionbiomarkerc-akt proteincancer cellcastration resistant CaPcastration resistant PCacastration resistant prostate cancercell morphologychromatin immunoprecipitation coupled with sequencingchromatin immunoprecipitation followed by sequencingchromatin immunoprecipitation with sequencingchromatin immunoprecipitation-seqchromatin immunoprecipitation-sequencingchromatin proteinclinical relevanceclinically relevantdetermine efficacydrug resistantefficacy analysisefficacy assessmentefficacy determinationefficacy evaluationefficacy examinationenzalutamideevaluate efficacyexamine efficacyexperimentexperimental researchexperimental studyexperimentsgenome mutationglucocorticoid-induced orphan receptorglucocorticoid-induced receptorhormone refractory prostate cancerhormone sensitive prostate cancerinhibitorinterestintervention efficacyknock-downknockdownmalignancymultiomicsmultiple omicsnecrocytosisneoplasm/cancernew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachpanomicspatient derived xenograft modelpharmacologicpre-clinical studypreclinical studyprostate cancer cell lineprostate cancer resistant to androgenproto-oncogene protein RACproto-oncogene protein aktrac protein kinasereceptorreceptor GPR83receptor expressionrelated to A and C-proteinresistance to Drugresistance to diseaseresistance to therapyresistantresistant diseaseresistant to Drugresistant to diseaseresistant to therapyresolutionsresponsesocial roletargeted drug therapytargeted drug treatmentstargeted therapeutictargeted therapeutic agentstargeted therapytargeted treatmenttherapeutic efficacytherapeutic evaluationtherapeutic resistancetherapeutic testingtherapy efficacytherapy resistanttranscriptomicstreatment resistancetumor
Description preview
PROJECT SUMMARY (ABSTRACT)
An evolving concept that contributes to our understanding of resistance to androgen deprivation therapy
(ADT) or androgen receptor (AR) antagonists in advanced prostate cancer (PCa) is the ability of cells to
evade AR blockade and turn on compensatory hormone receptor signaling for survival. Preclinical and
clinical…
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