grant
Post-transcription Initiation Control of Gene Expression
Organization PENNSYLVANIA STATE UNIVERSITY, THELocation UNIVERSITY PARK, UNITED STATESPosted 1 Sept 2024Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY20255' Untranslated Regions5'UTRAffectB subtilisB. subtilisBacillus subtilisBacteriaBinding ProteinsCell Communication and SignalingCell FunctionCell PhysiologyCell ProcessCell SignalingCellular FunctionCellular PhysiologyCellular ProcessChemicalsCollaborationsComparative StudyCouplingCryo-electron MicroscopyCryoelectron MicroscopyDNA-Dependent RNA PolymerasesDNA-Directed RNA PolymeraseE coliE. coliElectron CryomicroscopyEngineeringEscherichia coliEventGene Action RegulationGene ExpressionGene Expression RegulationGene RegulationGene Regulation ProcessGene TranscriptionGenesGenetic TranscriptionGenomeHealthHigh temperature of physical objectHumanIntracellular Communication and SignalingLigand Binding ProteinLigand Binding Protein GeneMessenger RNAMetabolicMethodsModern ManMolecularNon-Polyadenylated RNAORFsOpen Reading FramesOrganismPlayProcessProtein BindingProtein Coding RegionProteinsRNARNA ExpressionRNA Gene ProductsRNA PolymerasesRNA-Binding ProteinsRegulationRegulonResearchRibonucleic AcidRibosomal ProteinsRibosomesRoleSignal TransductionSignal Transduction SystemsSignalingSiteStressStructureSubcellular ProcessSystemTestingTranscriptionTranscription InitiationTranscriptional Elongation FactorsTransfer RNATranslationsTriplet Codon-Amino Acid AdaptorWorkbiological adaptation to stressbiological signal transductionbound proteincell typecryo-EMcryoEMcryogenic electron microscopyflexibilityflexibleglobal gene expressionglobal transcription profilehigh temperaturehuman diseaseimprovedin vivoinsightliving systemmRNAmRNA Leader Sequencesmetabolism measurementmetabolomicsmetabonomicsposttranscriptionalprogramsreaction; crisisrhosocial rolestress responsestress; reactiontRNAtermination factortranscription terminationtranscriptometransfer Ribonucleic acidstranslation
Description preview
Project Summary/Abstract
A unifying theme of my research program is to determine how RNA structure regulates gene expression
co-transcriptionally by affecting the activity of RNA polymerase (RNAP) or by affecting ribosome access to the
mRNA. Critical mechanistic insight into these processes will be obtained through comparative studies in…
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