grant
Population genotyping of the germline immunoglobulin repertoire in AIDS-designated rhesus macaque breeding colonies
NIHUS FederalResearch GrantFY202519S Gamma GlobulinAIDSAIDS VirusAb responseAcquired Immune DeficiencyAcquired Immune Deficiency SyndromeAcquired Immune Deficiency Syndrome VirusAcquired Immunodeficiency SyndromeAcquired Immunodeficiency Syndrome VirusAddressAllelesAllelomorphsAnimal ModelAnimal Models and Related StudiesAnimalsAntibodiesAntibody FormationAntibody ProductionAntigen-Antibody ComplexAntigenic DeterminantsAntigensApplications GrantsAutomobile DrivingAwardAwarenessB cell receptorB-Cell Antigen ReceptorB-cell receptor repertoire sequencingB-cell receptor sequencingBCR repertoire sequencingBCR seqBCR sequencingBCRseqBindingBinding DeterminantsClinicalCollaborationsCollectionCommunitiesComplexComputer softwareDNADNA RecombinationDNA SequenceDataData BasesData SetDatabasesDeoxyribonucleic AcidDevelopmentEpitopesEvolutionFAIR dataFAIR guiding principlesFAIR principlesFIRST AwardFindable, Accessible, Interoperable and Re-usableFindable, Accessible, Interoperable, and ReusableFirst Independent Research Support and Transition AwardsFunctional RNAFundingGene TargetingGeneHomologGenesGeneticGenetic PolymorphismGenetic RecombinationGenomeGenomicsGenotypeGerm LinesGoalsGrant ProposalsGraphHIVHIV vaccineHIV-1HIV-IHIV/AIDS VaccinesHIV1HandHaplotypesHomologHomologous GeneHomologueHumanHuman Immunodeficiency Virus Type 1Human Immunodeficiency VirusesHuman immunodeficiency virus 1Ig GenesIg Somatic HypermutationIgKIgMImmune ComplexImmune GlobulinsImmunityImmunizationImmunoglobulin GenesImmunoglobulin MImmunoglobulin Somatic HypermutationImmunoglobulinsIndividualLAV-HTLV-IIILightLymphadenopathy-Associated VirusM mulattaM. mulattaMacacaMacaca mulattaMacaca rhesusMacaqueMethodologyModelingModern ManMolecular InteractionNomenclatureNon-Polyadenylated RNANoncoding RNANontranslated RNAPeptide Signal SequencesPersonsPhasePhotoradiationPopulationPre-Clinical ModelPreclinical ModelsProtocolProtocols documentationR24RNARNA Gene ProductsRecombinationResearchResearch ResourcesResource DevelopmentResourcesRhesusRhesus MacaqueRhesus MonkeyRhesus macaque colonyRibonucleic AcidRoleSIVSamplingSerologySignal PeptideSignal SequencesSimian Immunodeficiency VirusesSoftwareStudy modelsSystemTraining ActivityUntranslated RNAVaccine ResearchVaccinesVariantVariationVirusVirus-HIVWorkanalysis pipelineantibody biosynthesiscombatdata basedata explorationdata sharingdepositorydevelopmentaldrivingentire genomefull genomegenetic analysisgenetic associationgenetic resourcegenome resourcegenomic datagenomic data resourcegenomic datasetgenomic resourcegenomic sequencing resourcegerm free conditionhandshuman immunodeficiency virus vaccinehuman modelimmunogenimmunoglobulin biosynthesisimprovedinfancyinfantilemodel of animalmodel of humanneutralizing antibodynoncodingnoveloutreachpan-genomepandemicpandemic diseasepangenomepolymorphismpre-clinicalpre-clinical assessmentpre-clinical studypreclinicalpreclinical assessmentpreclinical studyprotein signal sequencepublic repositorypublicly accessible repositorypublicly available repositoryrepositoryrhesus breeding colonyrhesus colonyrhesus macaque breeding colonyrhesus monkey breeding colonyrhesus monkey colonysocial rolesomatic hypermutationspecific pathogen freesuccesstooltraining moduleusabilityuser-friendlyvaccination studyvaccination trialvaccine responsevaccine responsivenessvaccine strategyvaccine studyvaccine trialvaccine-induced responsevaccine-related researchwhole genome
Description preview
PROJECT SUMMARY
An urgent priority of contemporary HIV vaccine research is the development of strategies to elicit broadly
neutralizing antibodies (bNAbs) capable of providing protection against diverse strains. Currently, some of the
most promising vaccine strategies are those in which specific classes of germline immunoglobulin (IG) genes
are…
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