grant
Population genomics and relapse epidemiology of Plasmodium ovale in sub-Saharan Africa
Organization UNIV OF NORTH CAROLINA CHAPEL HILLLocation CHAPEL HILL, UNITED STATESPosted 1 Aug 2024Deadline 31 Mar 2028
NIHUS FederalResearch GrantFY20250-11 years oldAcademiaActive Follow-upAfricaAfrica South of the SaharaAfricanAgeAreaBase PairingBehaviorBlood SampleBlood specimenCaringCentral AfricaChildChild YouthChildren (0-21)ClinicalClinical ClerkshipClinical ResearchClinical StudyCollectionCommunicable DiseasesCompetenceCountryDNADataDemographic FactorsDeoxyribonucleic AcidDoctor of PhilosophyEducationEducational aspectsEducational process of instructingEpidemiologic MethodologyEpidemiologic MethodsEpidemiologic research methodologyEpidemiologic research methodsEpidemiological MethodsEpidemiological TechniquesEpidemiologyEvaluationEventFrequenciesFutureGeneticGenetic DiversityGenetic MarkersGenetic VariationGenetic studyGenomeGenomic DNAGenomicsGenotypeGeographyGoalsHaplotypesHumanIndividualInfectionInfectious Disease EpidemiologyInfectious DiseasesInfectious DisorderInfectious EpidemiologyInterdisciplinary ResearchInterdisciplinary StudyInterventionInvestigationInvestmentsKnowledgeLeadershipLiverLocationMalariaMedicalMethodsMethods EpidemiologyMethods in epidemiologyModern ManMolecularMultidisciplinary CollaborationMultidisciplinary ResearchP falciparumP ovaleP vivaxP. falciparumP. ovaleP. vivaxP.falciparumPaludismParasitemiaParasitesParticipantPatientsPatternPh.D.PhDPhysiciansPlasmodium InfectionsPlasmodium falciparumPlasmodium ovalePlasmodium vivaxPolymerase Chain ReactionPopulationPrevalenceProspective cohortPublic HealthRecurrenceRecurrentRelapseResearchResolutionRiskRisk FactorsSamplingSchoolsScientistSeasonsSingle Base PolymorphismSingle Nucleotide PolymorphismStructureSub-Saharan AfricaSubsaharan AfricaSurvey InstrumentSurveysTanzaniaTeachingTimeTrainingTranslational ResearchTranslational ScienceTransmissionWorkactive followupagesbiomarker identificationburden of diseaseburden of illnesscareerco-infectioncohortcoinfectioncommunity marginalizationdensitydesigndesigningdisease burdenentire genomeepidemiologicepidemiologicalfollow upfollow-upfollowed upfollowupfull genomegDNAgene biomarkergene expression biomarkergene locusgene markergene signature biomarkergenetic analysisgenetic biomarkergenetic epidemiologic studygenetic epidemiologygenetic locusgenomic locationgenomic locushepatic body systemhepatic organ systemidentification of biomarkersidentification of new biomarkersimprovedinsightkidsmalaria infectionmalaria-infectedmalarial infectionmarginalized communitymarker identificationmicrobial genomicsneglectnew markernovel biomarkernovel markerparasaetemiapathogenpopulation healthpressurepreventpreventingresolutionsscreeningscreeningssegregationsexsingle nucleotide variantskillssynergismtargeted sequencingtooltranslation researchtranslational investigationtransmission processtreatment guidelineswhole genomeyoungster
Description preview
PROJECT SUMMARY/ABSTRACT
The clinical burden of malaria infections in sub-Saharan Africa has been of tantamount public health
importance for decades, but research and control efforts have previously focused on Plasmodium falciparum,
the most common and severe of the malaria parasites in the subcontinent. Expanded molecular surveillance
has…
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