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Pneumonia-induced microglial activation causes blood-brain barrier breakdown, astrocyte activation, and tau pathology
Organization UNIVERSITY OF SOUTH ALABAMALocation MOBILE, UNITED STATESPosted 1 Sept 2024Deadline 2 Sept 2025 ⚠️
NIHUS FederalResearch GrantFY20252019 novel corona virus2019 novel coronavirus2019-nCoVAD related dementiaADRDAffectAgeAirway infectionsAlzheimer's and related dementiasAlzheimer's dementia and related dementiaAlzheimer's dementia or related dementiaAlzheimer's disease and related dementiaAlzheimer's disease and related disordersAlzheimer's disease or a related dementiaAlzheimer's disease or a related disorderAlzheimer's disease or related dementiaAlzheimer's disease related dementiaAmazeAmentiaAstrocytesAstrocytusAstrogliaAutopsyBBB permeabilizationBBB permeableBacterial PneumoniaBlood - brain barrier anatomyBlood VesselsBlood brain barrier dysfunctionBlood capillariesBlood flowBlood-Brain BarrierBody TissuesBrainBrain Nervous SystemCOVID associated pneumoniaCOVID induced pneumoniaCOVID pneumoniaCOVID related pneumoniaCOVID-19 associated pneumoniaCOVID-19 induced pneumoniaCOVID-19 pneumoniaCOVID-19 related pneumoniaCOVID-19 viral pneumoniaCOVID-19 virusCOVID19 virusCephalalgiaCephalgiaCephalicCephalodyniaCerebrovascular CirculationChronicClinicalCoV-2CoV2CognitionCranialCranial PainDALYDataDegenerative Neurologic DisordersDeliriumDementiaDendritic SpinesDiseaseDisorderDoctor of PhilosophyDoseDrug TargetingDysfunctionEncephalonExperimental ModelsFunctional disorderGliaGlial CellsGliosisGoalsHead PainHeadacheHemato-Encephalic BarrierHortega cellHourHumanImpairmentInfectionInjuryIntensive Care UnitsInterviewInvestigatorsKolliker's reticulumLabelLungLung ParenchymaLung Respiratory SystemLung TissueLung infectionsMR ImagingMR TomographyMRIMRIsMT-bound tauMagnetic Resonance ImagingMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMentorsMethodsMiceMice MammalsMicrogliaMigraineMigraine HeadacheModelingModern ManMurineMusNMR ImagingNMR TomographyNerve CellsNerve UnitNervous System Degenerative DiseasesNervous System DiseasesNervous System DisorderNeural CellNeural Degenerative DiseasesNeural degenerative DisordersNeurocyteNeurodegenerative DiseasesNeurodegenerative DisordersNeurogliaNeuroglial CellsNeuroimmuneNeuroimmune MechanismsNeuroimmune ProcessesNeuroimmunomodulationNeurologic Degenerative ConditionsNeurologic DisordersNeurological DisordersNeuronsNeurovascular dysfunctionNon-neuronal cellNonneuronal cellNuclear Magnetic Resonance ImagingP aeruginosaP. aeruginosaPathologyPathway interactionsPatientsPersonsPh.D.PhDPhasePhysiopathologyPneumoniaPopulationPositionPositioning AttributePostdocPostdoctoral FellowPrevalenceProcessPseudomonas aeruginosaPseudomonas pyocyaneaQOLQuality of lifeR-Series Research ProjectsR01 MechanismR01 ProgramRNA SeqRNA sequencingRNAseqRegulationResearchResearch AssociateResearch GrantsResearch PersonnelResearch Project GrantsResearch ProjectsResearchersRespiratory InfectionsRespiratory Tract InfectionsSARS corona virus 2SARS-CO-V2SARS-COVID-2SARS-CoV-2SARS-CoV-2 associated pneumoniaSARS-CoV-2 induced pneumoniaSARS-CoV-2 pneumoniaSARS-CoV-2 related pneumoniaSARS-CoV-2 viral pneumoniaSARS-CoV2SARS-associated corona virus 2SARS-associated coronavirus 2SARS-coronavirus-2SARS-related corona virus 2SARS-related coronavirus 2SARSCoV2Severe Acute Respiratory Coronavirus 2Severe Acute Respiratory Distress Syndrome CoV 2Severe Acute Respiratory Distress Syndrome Corona Virus 2Severe Acute Respiratory Distress Syndrome Coronavirus 2Severe Acute Respiratory Syndrome CoV 2Severe Acute Respiratory Syndrome-associated coronavirus 2Severe Acute Respiratory Syndrome-related coronavirus 2Severe acute respiratory syndrome associated corona virus 2Severe acute respiratory syndrome coronavirus 2Severe acute respiratory syndrome related corona virus 2Structure of parenchyma of lungSurvivorsSynaptic plasticitySyndromeTauopathiesTechniquesTestingTissuesTrainingWild Type MouseWorkWuhan coronavirusZeugmatographyagesastrocytic gliabacteria pneumoniablood flow in brainblood-brain barrier permeabilizationblood-brain barrier permeablebloodbrain barrierbloodbrain barrier permeabilizationbloodbrain barrier permeablebrain blood circulationbrain blood flowbrain tissuecapillarycerebral blood flowcerebral circulationcerebrocirculationcerebrovascular blood flowcognitive functionconferenceconventioncoronavirus disease 2019 associated pneumoniacoronavirus disease 2019 induced pneumoniacoronavirus disease 2019 pneumoniacoronavirus disease 2019 related pneumoniacoronavirus disease 2019 viruscoronavirus disease associated pneumoniacoronavirus disease induced pneumoniacoronavirus disease pneumoniacoronavirus disease related pneumoniacoronavirus disease-19 pneumoniacoronavirus disease-19 viruscytotoxicdegenerative diseases of motor and sensory neuronsdegenerative neurological diseasesdeliriousdendrite spinedensitydisabilitydisability-adjusted life yearseffective therapyeffective treatmentexperiencegitter cellglial activationglial cell activationhCoV19head achehigh riskimaging in miceimaging studies for miceimaging studies in miceimaging studyin vivoinjuriesintra-vital imagingintravital imaginglearning activitylearning methodlearning strategieslearning strategylongitudinal imagingmesogliamice imagingmicroglial cellmicrogliocytemicrotubule bound taumicrotubule-bound taumigraine therapymigraine treatmentmouse modelmulti-photon imagingmultiphoton imagingmurine imagingmurine modelnCoV2necropsynerve cementneural inflammationneuro-vascularneuro-vascular unitneurodegenerative illnessneuroinflammationneuroinflammatoryneurological diseaseneuronalneuropathologic tauneuropathological tauneurovascularneurovascular abnormalityneurovascular dysregulationneurovascular impairmentneurovascular pathologyneurovascular unitneurovasculopathynew drug targetnew drug treatmentsnew druggable targetnew drugsnew pharmacological therapeuticnew pharmacotherapy targetnew therapeutic targetnew therapeuticsnew therapynew therapy targetnext generation therapeuticsnovel drug targetnovel drug treatmentsnovel druggable targetnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel pharmacotherapy targetnovel therapeutic targetnovel therapeuticsnovel therapynovel therapy targetp-taup-τpathogenpathophysiologypathwayperivascular glial cellphospho-tauphospho-τphosphorylated taupneumonia due to COVIDpneumonia due to COVID-19pneumonia due to SARS-CoV-2pneumonia due to coronavirus diseasepneumonia due to coronavirus disease 2019pneumonia due to severe acute respiratory syndrome coronavirus 2pneumonia in COVIDpneumonia in COVID-19pneumonia in SARS-CoV-2pneumonia in coronavirus diseasepneumonia in coronavirus disease 2019pneumonia in severe acute respiratory syndrome coronavirus 2post-docpost-doctoralpost-doctoral traineepost-translational modification of taupostmortemposttranslational modification of taupulmonary infectionsresearch associatesserial imagingsevere acute respiratory syndrome coronavirus 2 associated pneumoniasevere acute respiratory syndrome coronavirus 2 induced pneumoniasevere acute respiratory syndrome coronavirus 2 pneumoniasevere acute respiratory syndrome coronavirus 2 related pneumoniaskillssummitsymposiasymposiumtautau Proteinstau associated neurodegenerationtau associated neurodegenerative processtau driven neurodegenerationtau factortau induced degenerationtau induced neurodegenerationtau mediated neurodegenerationtau neurodegenerative diseasetau neuropathologytau pathologytau pathophysiologytau phosphorylationtau posttranslational modificationtau proteinopathytau related neurodegenerationtau-1tau-induced pathologytauopathic neurodegenerative disordertauopathytemporal measurementtemporal resolutiontherapeutic targettime measurementtimelinetranscriptome sequencingtranscriptomic sequencingvascularvascular contributionswildtype mouseτ Proteinsτ phosphorylation
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PROJECT SUMMARY / ABSTRACT
Many survivors of respiratory infections (i.e., pneumonia, and SARS-CoV-2) have subsequent incident dementia
causing decreased quality of life and are at a higher risk of developing Alzheimer’s disease and related
dementias. The cause of this association between pneumonia and dementia is unknown. It is also unknown how…
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