grant
Platelet-mitochondria transplantation to treat mitochondrial dysfunction in acute kidney injury
Organization TEMPLE UNIV OF THE COMMONWEALTHLocation PHILADELPHIA, UNITED STATESPosted 4 Apr 2023Deadline 31 Jan 2028
NIHUS FederalResearch GrantFY2026Active OxygenAcuteAcute Kidney FailureAcute Kidney InsufficiencyAcute Renal FailureAcute Renal InsufficiencyAreaAzotemiaBlood PlateletsBody TissuesBreast CancerCDDPCardiovascularCardiovascular Body SystemCardiovascular Organ SystemCardiovascular systemCausalityCell BodyCell FunctionCell Growth in NumberCell MultiplicationCell PhysiologyCell ProcessCell ProliferationCellsCellular FunctionCellular PhysiologyCellular ProcessCellular ProliferationChronic Kidney FailureChronic Renal DiseaseChronic Renal FailureCis-diammine-dichloroplatinumCis-diamminedichloridoplatinumCis-diamminedichloro Platinum (II)Cis-dichloroammine Platinum (II)Cis-platinous Diamine DichlorideCis-platinum IICis-platinum II Diamine DichlorideCisplatinCisplatinaCisplatinumCollaborationsCritical CareCysplatynaCytochrome OxidaseCytoplasmD-GlucoseDeteriorationDextroseDiabetes MellitusDialysisDialysis procedureDichlorodiammineplatinumDiseaseDisorderDrug toxicityDrugsESKDESRDElectric ResistanceElectrical ResistanceElectrolyte DisorderElectron Transport Complex IVEncapsulatedEnd stage renal failureEnd-Stage Kidney DiseaseEnd-Stage Renal DiseaseEndocytosisEpithelial CellsEtiologyEventExcretory functionFacultyFerrocytochrome c Oxygen OxidoreductaseFluorescenceGeneralized GrowthGlucoseGrowthHealthHeartHeart Valve DiseasesHeart VascularHeart failureHepatic CellsHepatic Parenchymal CellHepatocyteHospital AdmissionHospitalizationHuman FigureHuman bodyHypoxiaHypoxicIn VitroIncidenceInjuryInjury to KidneyIntercellular nanotubesInterstitial NephritisIonsIschemic HeartIschemic Heart DiseaseIschemic myocardiumKidneyKidney DiseasesKidney Replacement TherapyKidney Urinary SystemLeadLiver CellsMalignant Breast NeoplasmMarrow plateletMeasuresMedicationMedicineMitochondriaMorbidityMyocardial IschemiaNephrologyNephropathyNutrientOccluding JunctionsOrganOxygen ConsumptionOxygen DeficiencyOxygen RadicalsPatientsPb elementPeyrone's ChloridePeyrone's SaltPharmaceutical PreparationsPlateletsPlatinum DiamminodichloridePositionPositioning AttributePreventative strategyPrevention strategyPreventive strategyPro-OxidantsProcessProductionPrognosisProtein Synthesis InhibitionReactive Oxygen SpeciesRecoveryRenal CellRenal DiseaseRenal Replacement TherapyRenal functionSourceStructureSubcellular ProcessTestingTherapeuticTherapeutic InterventionThrombocytesTight JunctionsTissue GrowthTissuesTransmission Electron MicroscopyTransplantationTubularTubular formationUremiaValvular Heart DiseasesValvular Heart DisorderVesicleVisualizationZonula Occludensabsorptionacute kidney injurycardiac failurecardiac ischemiacardiac valve diseasecardiac valve disordercardiac valvular diseasecausationcell dedifferentiationchronic kidney diseasecirculatory systemcis dichlorodiammineplatinumcis platinum compoundcis-Diaminedichloroplatinumcis-Diamminedichloroplatinumcis-Diamminedichloroplatinum(II)cis-Dichlorodiammineplatinum(II)cis-Platinumcoronary ischemiacyclosporin A-SPTPcyclosporin A-sensitive pereability transition porecytochrome c oxidasedegenerative valvular heart diseasediabetesdialysis therapydisease causationdrug/agentexcretionfatty acid oxidationfluorescence imagingfluorescent imagingheart ischemiaheart valve disorderheavy metal Pbheavy metal leadin vivoinjuriesinjury responseinnovateinnovationinnovativeinsightintervention therapyischemia injuryischemic injurykidney cellkidney disorderkidney functionkidney injurykidney ischemiamalignant breast tumormembermembrane nanotubesmembranous nanotubesmicrovesiclesmitochondrialmitochondrial dysfunctionmitochondrial megachannelmitochondrial permeability transition poremortalitymyocardial ischemia/hypoxiamyocardium ischemianew approachesnew therapeutic approachnew therapeutic interventionnew therapeutic strategiesnew therapy approachesnew treatment approachnew treatment strategynovel approachesnovel strategiesnovel strategynovel therapeutic approachnovel therapeutic interventionnovel therapeutic strategiesnovel therapy approachontogenyoxidant stresspharmacologicpreventpreventingrenalrenal disorderrenal injuryrenal ischemiaresponse to injurysensorsuper high resolutionsuperresolutiontherapeutically effectivetooltransplanttunneling nanotubesultra high resolutionultra resolutionultrafine resolutionuptakeuremia of renal origin
Description preview
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This project responds directly to PAR-21-038; the PI changes direction from valvular heart disease to study acute kidney injury (AKI). Indeed, the PI is a new faculty member in the Division of Nephrology, Department of Medicine. The PI will apply her previous expertise in platelet structure to examine a new…
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