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Plasticity of GABA input to VTA dopamine neurons in opioid use disorders
Organization OKLAHOMA CITY VA MEDICAL CENTERLocation OKLAHOMA CITY, UNITED STATESPosted 1 Oct 2021Deadline 30 Sept 2025 β οΈ
VANIHUS FederalResearch GrantFY20254-Aminobutanoic Acid4-Aminobutyric Acid4-amino-butanoic acidALDH1ALDH1 enzymeAblationAbstinenceActiqAdeno-Associated VirusesAffectAffinity ChromatographyAgingAllelesAllelomorphsAminalonAminaloneAreaAstrocytesAstrocytusAstrogliaAttentionBehaviorBehavioralBioinformaticsBrainBrain Nervous SystemBreedingCRE RecombinaseCell Communication and SignalingCell NucleusCell SignalingChestClinicalCodeCoding SystemCommon Rat StrainsCre Lox technologyCre LoxP systemCre lox recombinationCre lox recombination systemCre lox systemCre recombinase/LoxP technologyCre systemCuesDA NeuronDAT dopamine transporterDNADREADDsDataDeoxyribonucleic AcidDependoparvovirusDependovirusDevelopmentDiseaseDisinhibitionDisorderDopamine neuronDrugsDuragesicElectrophysiologyElectrophysiology (science)EncephalonEnterobacteria phage P1 Cre recombinaseFamily memberFemaleFentanestFentanylFentylGABAGene ExpressionGene ModifiedGeneral PopulationGeneral PublicGenesGeneticGleanHistoryHypothalamic structureHypothalamusIndividualInjectionsIntakeIntracellular Communication and SignalingKnock-outKnockoutKnowledgeLabelLateralLinkLoxP-flanked alleleMaintenanceMeasuresMediatingMedicationMiceMice MammalsMolecularMurineMusNerve CellsNerve Transmitter SubstancesNerve UnitNeural CellNeural TransmissionNeurocyteNeuronsNeurophysiology / ElectrophysiologyNeurotensinNeurotensin ReceptorsNeurotransmittersNociceptionNon-Polyadenylated RNANuclearNucleic AcidsNucleusNucleus AccumbensOpiate ReceptorsOpiatesOpioidOpioid ReceptorOverdosePainPain ControlPain TherapyPain managementPainfulPathway interactionsPeptidesPharmaceutical PreparationsPhentanylPhysiologicPhysiologicalProceduresPropertyPsychological reinforcementPublic HealthQOL improvementRNARNA Gene ProductsRatRats MammalsRattusReceptor ProteinReceptor SignalingRecording of previous eventsReinforcementRelapseRibonucleic AcidRibosomesRiskRoleSelf AdministeredSelf AdministrationSignal TransductionSignal Transduction SystemsSignalingSiteSliceSourceSuicideSynapsesSynapticSynaptic TransmissionSynaptic plasticitySystemTechniquesTestingThoraceThoracicThoraxTitrationsTranslatingVGAT transporterVentral Tegmental AreaVeteransViralVirusWithdrawalWorkWritingadeno associated virus groupadverse consequenceadverse outcomeaffinity purificationaldehyde dehydrogenase 1analogastrocytic gliabacteriophage P1 recombinase Crebiological signal transductioncell typechronic pain controlchronic pain interventionchronic pain managementchronic pain therapychronic pain treatmentdesigner receptors exclusively activated by designer drugsdevelopmentaldopamine transporterdopaminergic neurondrug reinforcementdrug/agentelectrophysiologicalepigenomicsexperienceexperimentexperimental researchexperimental studyexperimentsfatal attemptfatal suicidefloxedfloxed allelegamma-Aminobutyric Acidgene interactiongene modificationgenetically modifiedglobal gene expressionglobal transcription profilehistorieshypothalamicimprovedimprovements in QOLimprovements in quality of lifeinnovateinnovationinnovativeintent to dielicit opioidmalemouse geneticsmu opioid receptorsneuronalneuronal excitabilityneurophysiologicalneurophysiologynew drug targetnew druggable targetnew pharmacotherapy targetnew therapeutic targetnew therapy targetnociceptivenovelnovel drug targetnovel druggable targetnovel pharmacotherapy targetnovel therapeutic targetnovel therapy targetopiate abuseopiate consumptionopiate crisisopiate drug abuseopiate drug useopiate exposureopiate intakeopiate medicationopiate useopiate use disorderopioid abuseopioid consumptionopioid crisisopioid drug abuseopioid drug useopioid epidemicopioid exposureopioid intakeopioid medicationopioid useopioid use disorderoptogeneticspain interventionpain treatmentpatch clamppathwayprescribed opiateprescribed opioidprescription opiateprescription opioidpresynapticquality of life improvementreceptorremifentanilside effectsocial rolesuicidal risksuicide risksuicidessynapsetooltranscriptometranscriptomicstreat chronic paintreatment strategyventral tegmentumvesicular GABA transporterΞ³-Aminobutyric AcidΞΌ opioid receptorsΞΌ-ORΞΌORββ
Applications closed.
Description preview
Despite their dangers, the number of opioid prescriptions written for veterans has increased sharply since
2000, and veterans are more prone than the general population to both suicide and the development of use
disorders following opioid treatment. Target receptors for opioids are widely expressed throughout the brain
and periphery, but theirβ¦
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