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Planar Cell Polarity Control in Melanoma Metastasis
Organization WM S. MIDDLETON MEMORIAL VETERANS HOSPLocation MADISON, UNITED STATESPosted 1 Apr 2022Deadline 31 Mar 2026 ⚠️
VANIHUS FederalResearch GrantFY2025AfghanistanAllelesAllelomorphsArmed Forces PersonnelB-raf-1BRAFBRAF geneBehaviorBlocking AntibodiesBody TissuesCCND1 ProteinCancer PatientCancersCardiac MalformationCell BodyCell Growth in NumberCell LineCell LocomotionCell MigrationCell MovementCell MultiplicationCell PolarityCell ProliferationCellLineCellsCellular MigrationCellular MotilityCellular ProliferationCessation of lifeChimeraChimera organismCleft PalateCyclin D1DeathDefectDevelopmentDiagnosisDiseaseDisease OutcomeDisorderDistant CancerDistant MetastasisDrugsEctopic ExpressionExposure toFutureG1/S-Specific Cyclin D1GenesGenetic studyGenomicsGoalsHealth CareHeart MalformationHumanIn VitroInvadedIraqKnock-outKnockoutLungLung Respiratory SystemLysosomesMEKsMMPsMalignant MelanomaMalignant NeoplasmsMalignant Skin NeoplasmMalignant TumorMatrix MetalloproteinasesMediatingMedicationMelaninsMelanomaMelanoma CellMelanoma MetastasisMetabolic Protein DegradationMetastasisMetastasis to the LungMetastasizeMetastatic LesionMetastatic MassMetastatic MelanomaMetastatic NeoplasmMetastatic Neoplasm to the LungMetastatic TumorMetastatic Tumor to the LungMiceMice MammalsMilitaryMilitary PersonnelMissionModern ManMonitorMurineMusNeoplasm MetastasisNeural Tube DefectsNeural Tube Developmental DefectsOrganPDX modelPRAD1 ProteinPathway interactionsPatient derived xenograftPatientsPharmaceutical PreparationsPolycystic KidneyPolycystic Kidney DiseasesProcessProtein TurnoverProteinsProto-Oncogene Proteins c-bcl-1RAFB1Ras/RafRecurrenceRecurrentRegulatory Protein DegradationResearchRoleSamplingSecondary NeoplasmSecondary TumorSignal PathwaySkinSkin CancerSkin NeoplasmsSkin TumorStrains Cell LinesSunlightSystemTechnologyTestingTherapeuticTissue ArraysTissue ChipTissue MicroarrayTissuesTransgenic MiceTumor CellTumor Cell MigrationTumor PromotionUnited States Department of Veterans AffairsUnited States Veterans AdministrationVectraVeteransVeterans AdministrationVeterans AffairsWorkabnormal heart developmentbcl-1 Proto-Oncogene Productsbcl-1 Proto-Oncogene Proteinsbcl1 Proto-Oncogene Proteinsc-bcl-1 Proteinscancer diagnosiscancer metastasiscancer registrycell killingcell motilitycellular polaritychimerasclinical relevanceclinically relevantcongenital cardiac abnormalitycongenital cardiac anomaliescongenital cardiac diseasecongenital cardiac disordercongenital cardiac malformationcongenital heart abnormalitycongenital heart anomalycongenital heart diseasecongenital heart disordercongenital heart malformationcultured cell linecyclin Ddeafnessdevelopmentaldrug developmentdrug discoverydrug/agentepithelial to mesenchymal transitionexperimentexperimental researchexperimental studyexperimentsgain of functionhigh riskhuman diseasehuman tissuein vivoindexinginnovateinnovationinnovativeinsightinterdisciplinary approachknock-downknockdownliquid crystal polymerlive cell imagelive cell imaginglive cellular imagelive cellular imagingloss of functionlung metastasismalignancymalignant skin tumormelanocytemelanoma cancer modelmelanoma modelmelanoma tumor modelmetastasize to the lungmilitary populationmilitary veteranmouse modelmultidisciplinary approachmurine modelmutantneoplasm registryneoplasm/cancerneoplastic cellnew approachesnovelnovel approachesnovel strategiesnovel strategyoverexpressoverexpressionpathwaypatient derived xenograft modelplanar cell polaritypreventpreventingprogramsprospectiveprotein degradationpulmonary metastasissocial rolesun lightsurvivorshiptranscriptomicstumor cell metastasisultra violetultravioletv-raf Murine Sarcoma Viral Oncogene Homolog B1veteran population
Applications closed.
Description preview
Melanoma is a highly aggressive cancer that begins in melanin-producing melanocytes in the skin. It accounts
for only about 1% of skin cancers, but it is the leading cause of skin cancer deaths. US military personnel have
higher rates of melanoma than civilians because of the heavy exposure to sunlight in the deployment setting.
Based on the…
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