grant
PKR sensing of mitochondrial dsRNA in childhood Sjogrens disease
Organization UNIVERSITY OF FLORIDALocation GAINESVILLE, UNITED STATESPosted 8 Sept 2023Deadline 30 Jun 2028
NIHUS FederalResearch GrantFY20250-11 years old21+ years oldAddressAdhesionsAdolescentAdolescent YouthAdultAdult HumanAffectAnti-InflammatoriesAnti-Inflammatory AgentsAnti-inflammatoryAreaAsialiaAutoimmuneAutoimmune DiseasesAutologousAwardB-Cell NHLB-Cell Non-Hodgkin's LymphomaB-Cell NonHodgkins LymphomaBar CodesBinding ProteinsBiologicalBiopsyBlood monocyteBody TissuesCD14CD14 geneCD52CDW52CDW52 geneCell BodyCell LineCellLineCellsChildChild YouthChildhoodChildren (0-21)ClinicalCo-ImmunoprecipitationsCollaborationsCytoplasmDNA HelicasesDNA Unwinding ProteinsDNA unwinding enzymeDataData SetDepositDepositionDevelopmentDiagnosticDiseaseDisorderDouble-Stranded RNADown-RegulationEarly InterventionElderlyEndothelial CellsEnrollmentExocrine GlandsExploratory/Developmental Grant for Diagnostic Cancer ImagingExtravasationFemaleFoundationsFundingGene AmplificationGene ExpressionGene TargetingGenesGeneticGoalsHealthHeterogeneityHomingHospitalsHyposalivationIFNImmuneImmune Cell ActivationImmune RegulatorsImmunesImmunochemical ImmunologicImmunologicImmunologicalImmunologicallyImmunologicsImmunomodulatorsImpairmentIncidenceInflammationInflammatoryInterferonsInvestigationKnowledgeLaboratoriesLacrimal deficiencyLeakageLigand Binding ProteinLigand Binding Protein GeneLipLip structureMarrow monocyteMediatingMedicalMethylationMitochondriaMitochondria RNAMitochondrial ProteinsMitochondrial RNAMolecularMolecular AnalysisMolecular DiseaseMouth DrynessNIAMSNational Institute of Arthritis, and Musculoskeletal, and Skin DiseasesNational Institutes of HealthNatural HistoryNon-Polyadenylated RNANucleic AcidsOcular desiccationOrganOrphan DiseaseOutcomePBMCParticulatePathogenesisPathway interactionsPatientsPeripheral Blood Mononuclear CellPolynucleotide PhosphorylasePolyribonucleotide NucleotidyltransferasePrevalencePrognostic MarkerProtein BindingR21 AwardRNARNA BindingRNA DegradationRNA Gene ProductsRNA HelicaseRNA SeqRNA based therapeuticsRNA based therapyRNA boundRNA sequencingRNA therapyRNA-Binding ProteinsRNAseqRare DiseasesRare DisorderResearchRibonucleic AcidSTAT1STAT1 geneSTAT91Salivary hypofunctionSicca SyndromeSjogren's DiseaseSjogren's SyndromeSjogrensSjögren SyndromeSpillageStaining methodStainsStrains Cell LinesStratificationTestingTissuesTranscriptUnited States National Institutes of HealthUpregulationValidationXerostomiaXerostomicadulthoodadvanced ageaptyalismautoimmune conditionautoimmune disorderautoimmunity diseasebarcodebiologicbiomarker discoverybound proteincohortcultured cell linedevelopmentaldiagnostic biomarkerdiagnostic criteriadiagnostic markerdry eyedry mouthdsRNAenrolleye drynessgene signaturesgenetic signaturegeriatrichelicaseimmune activationimmune modulatorsimmunomodulatory moleculesimmunoregulatorimmunoregulatory moleculesinnate immune mechanismsjuvenilejuvenile humankidsmitochondrialmonocytemonomermtRNAmultidisciplinarymultiomicsmultiple omicsnatural gene amplificationnovelocular drynessocular signs of drynessocular surface drynessoral drynessorphan disorderoverexpressoverexpressionpanomicspathwaypediatricpersonalization of treatmentpersonalized medicinepersonalized therapypersonalized treatmentprecision medicineprecision-based medicinepreventpreventingprognostic biomarkerprognostic indicatorprotein kinase Rsalivary gland hypofunctionscRNA sequencingscRNA-seqsenior citizensensorsimulationsingle cell RNA-seqsingle cell RNAseqsingle cell expression profilingsingle cell transcriptomic profilingsingle-cell RNA sequencingtear deficiencytherapeutic RNAtherapeutic targettranscriptome sequencingtranscriptomic sequencingtranscriptomicsvalidationsxerodermosteosisyoungster♀
Description preview
ABSTRACT
Through our multidisciplinary clinical and research collaboration, we have established a rare cohort of children and
adolescents who fulfilled the 2016 adult Sjögren’s disease (SjD) criteria (namely, cSjD for childhood Sjögren’s
disease). Since autoimmune SjD typically affects elderly females, whether cSjD is a unique disease entity or an…
🔒
Start 7-day free trial — $29.99/mo →Full details available on the Agency plan
Unlock the complete grant description, eligibility criteria, contract value, evaluation details and apply link — plus alerts, pipeline tracking, and CSV export.
Agency Plan
7-day free trialUnlock procurement & grants
Upgrade to access active tenders from World Bank, UNDP, ADB and more — with email alerts and pipeline tracking.
$29.99 / month
- 🔔Email alerts for new matching tenders
- 🗂️Track tenders in your pipeline
- 💰Filter by contract value
- 📥Export results to CSV
- 📌Save searches with one click