grant
Pilot Project #1
Organization HOWARD UNIVERSITYLocation WASHINGTON, UNITED STATESPosted 20 Sept 2024Deadline 31 Aug 2029
NIHUS FederalResearch GrantFY20253-D3-Dimensional3DAddressAdvanced CancerAdvanced Malignant NeoplasmAfrican AmericanAfro AmericanAfroamericanAmerican maleAmerican manAmerican menAnatomic SitesAnatomic structuresAnatomyAngiogramAngiographyAreaArteriesBiopsyBlood TestsBlood VesselsCancer BurdenCancer CauseCancer EtiologyCancer PrognosisCancersCastrationCaucasian maleCaucasian menCell BodyCell Communication and SignalingCell SignalingCellsCessation of lifeChemical DynamicsChemicalsClinicalComputer ModelsComputerized ModelsD-GlucoseDataDeathDeath RateDetectionDevelopmentDextroseDiagnosisDiagnostic MethodDiagnostic ProcedureDiagnostic TechniqueDigital Rectal ExaminationDimensionsDiseaseDisease ResistanceDisorderDisparitiesDisparityEC 3.4.21.34EconomicsEnergy ExpenditureEnergy MetabolismEthnic GroupEthnic PeopleEthnic PopulationEthnic individualEthnicity PeopleEthnicity PopulationFOLHFOLH1FOLH1 geneFolate Hydrolase 1GCP2GlucoseGlutamate Carboxypeptidase IIH+ elementHealthHematologic TestsHematological TestsHematology TestingHistologyHydrogen IonsImageImaging DeviceImaging InstrumentImaging ProceduresImaging TechnicsImaging TechniquesImaging ToolImaging technologyImprove AccessIncidenceInstitutionIntermediary MetabolismIntracellular Communication and SignalingKallikrein 3LinkLiquid substanceMR ImagingMR TomographyMRIMRIsMachine LearningMagnetic Resonance ImagingMalignant NeoplasmsMalignant TumorMalignant neoplasm of prostateMalignant prostatic tumorMapsMeasurementMeasuresMedical Imaging, Magnetic Resonance / Nuclear Magnetic ResonanceMetabolicMetabolic ProcessesMetabolismMethodologyMiceMice MammalsModelingMolecularMolecular ComputationsMurineMusN-Acetylated Alpha-Linked Acidic Dipeptidase 1NAALAD1NAALADase INMR ImagingNMR TomographyNational Cancer BurdenNuclear Magnetic Resonance ImagingOrganP-30 AntigenPSA screeningPSA testPSMPSMAPatientsPerfusionPilot ProjectsPlasma Kallikrein PrecursorPlasma PrekallikreinPrognosisProstate CAProstate CancerProstate NeoplasmsProstate Specific Antigen PreproproteinProstate TumorProstate malignancyProstate-Specific AntigenProstate-Specific Membrane AntigenProstatic NeoplasiaProstatic NeoplasmsProstatic ParenchymaProstatic TissueProtonsQOCQuality of CareRecoveryResearch ResourcesResearch SupportResolutionResourcesRiskSamplingScreening for Prostate CancerSemenogelaseSemininSeverity of illnessSignal TransductionSignal Transduction SystemsSignalingSurgical CastrationTechniquesTechnologyTimeTracerTrainingTransrectal UltrasoundU.S. MalesUS MenUS maleValidationVariantVariationZeugmatographyadversarial neural networkanatomic imaginganatomical imagingangiographic imagingassess effectivenessbio-printingbiological signal transductionbioprintingburden of diseaseburden of illnesscancer progressioncomputational modelingcomputational modelscomputer based modelscomputer based predictioncomputerized modelingcostcost efficientdeep learningdeep learning methoddeep learning strategydetect prostate cancerdetection methoddetection proceduredetection techniquedetermine effectivenessdevelopmentaldisease burdendisease severitydisparities in mortalityeconomiceffectiveness assessmenteffectiveness evaluationethnic subgroupethnicity groupevaluate effectivenessexamine effectivenessexperimentexperimental researchexperimental studyexperimentsfluidgamma-Seminoproteingenerative adversarial networkgenerative neural networkglucose metabolismglucose uptakehK3 Kallikreinhemodynamicshigh resolution imagingimage processingimage-based methodimagingimaging methodimaging modalityimprovedliquidmachine based learningmachine learning based modelmachine learning modelmales in Americamales in the U.S.males in the USmales in the USAmales in the United Statesmalignancymenmen in Americamen in the U.S.men in the USmen in the USAmen in the United Statesmetabolic imagingmolecular imagingmolecule imagingmortalitymortality disparitymortality ratemortality rationeoplasm progressionneoplasm/cancerneoplastic progressionnew technologynon-invasive imagingnoninvasive imagingnovelnovel technologiesoptic imagingoptical imagingpilot studypredictive modelingprostate biopsyprostate cancer detectionprostate cancer early detectionprostate cancer progressionprostate specific antigen screeningprostate specific antigen testresistance to diseaseresistant diseaseresistant to diseaseresolutionssimulationsuper high resolutionsuperresolutiontemporal measurementtemporal resolutionthree dimensionaltime measurementtumortumor progressiontumor xenograftultra high resolutionvalidationsvascularwhite malewhite men
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Project Summary/Abstract
Prostate cancer is a leading cause of cancer-related death in men. Novel technologies can improve access to high-quality care—particularly for patients at increased risk of aggressive disease or living in areas with a high prostate cancer burden. Current diagnostic methods, including PSA testing and biopsy, are often…
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