grant
Phototransduction in health and disease
Organization UNIVERSITY OF SOUTHERN CALIFORNIALocation Los Angeles, UNITED STATESPosted 1 Mar 1998Deadline 29 Feb 2028
NIHUS FederalResearch GrantFY2025AcuteAffectArrestinsAttenuatedAutoregulationBlindnessCa2+-Activated ProteaseCalciumCalcium-Activated Neutral ProteaseCalcium-Activated Neutral ProteinaseCalcium-Activated ProteaseCalcium-Dependent Neutral ProteaseCalcium-Dependent Neutral ProteinaseCalibrationCalpainCell BodyCell CompartmentationCell CompartmentationsCell DeathCell membraneCellsChimera ProteinChimeric ProteinsCone PhotoreceptorsCrowdingCyclic GMPCytoplasmic MembraneDNA mutationDarknessDesminaseDiseaseDisorderDysfunctionEnvironmentEnvironmental FactorEnvironmental Risk FactorEquilibriumExposure toFP593FailureFeedbackFemaleFluorescenceFunctional ImagingFunctional disorderFusion ProteinG-ProteinsGTP-Binding ProteinsGTP-Regulatory ProteinsGenesGenetic ChangeGenetic defectGenetic mutationGuanine Nucleotide Coupling ProteinGuanine Nucleotide Regulatory ProteinsGuanosine Cyclic MonophosphateHealthHomeostasisHumanHydrolysisImageIntegral Membrane ProteinIntrinsic Membrane ProteinInvestigationKnowledgeLeadLightLight Signal TransductionMaintenanceMeasurementMiceMice MammalsMicroscopeMitochondriaModelingModern ManMolecularMurineMusMutant Strains MiceMutationNerve CellsNerve UnitNeural CellNeurocyteNeuronsPapain-Like Cysteine ProteasePathologicPb elementPerformancePhotonsPhotoradiationPhotoreceptor CellPhotoreceptorsPhotosensitive CellPhototransductionPhysiologic ImagingPhysiological HomeostasisPhysiopathologyPigmentary RetinopathyPlasma MembraneProcessRegulationReporterRetinaRetinal ConeRetinal DegenerationRetinal PigmentsRetinal S-AntigenRetinitis PigmentosaRhodopsinRod PhotoreceptorsRods and ConesRoleRouteSignaling Factor Proto-OncogeneSignaling Pathway GeneSignaling ProteinSliceStressSynapsesSynapticTapetoretinal DegenerationTestingTimeTransmembrane ProteinTransmembrane Protein GeneVertebrate PhotoreceptorsVision DisordersVisual DisorderVisual PigmentsVisual PurpleVisual ReceptorVisual TransductionVisualizationattenuateattenuatesbalancebalance functioncGMPcalcium indicatorcone celldegenerative retina diseasesdrFP583ds red proteindsFP593environmental riskexperimentexperimental researchexperimental studyexperimentsexposure to lightexposure to visible lightfluorescence imagingfluorescent imaginggenome mutationheavy metal Pbheavy metal leadhereditary blindnessimagingimaging detectorintervention designlight exposurelight pollution exposurelive cell imagelive cell imaginglive cellular imagelive cellular imagingmalemitochondrialmitochondrial dysfunctionmouse modelmouse mutantmulti-photonmurine modelmutantnecrocytosisneuronalnew drug treatmentsnew drugsnew pharmacological therapeuticnew therapeuticsnew therapynext generation therapeuticsnovel drug treatmentsnovel drugsnovel pharmaco-therapeuticnovel pharmacological therapeuticnovel therapeuticsnovel therapypathophysiologyphosphodiesterase 6phosphodiesterase type 6photoreceptor degenerationphysiological imagingplasmalemmapreventpreventingratiometricrecruitred fluorescent proteinretina degenerationretina photosensitive pigmentretinal degenerativeretinal degenerative diseasesretinal phosphodiesterase 6retinal rodsrod and cone dystrophyrod cellrod-cone dystrophysensorsocial rolesynapsetherapy designtooltreatment designvision lossvisual lossvisual phototransduction♀♂
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Abstract
Cyclic GMP and calcium (Ca2+) are effectors of phototransduction and maintenance of their homeostasis is
critical for photoreceptor cell health and function. Indeed, perturbance of this homeostasis is thought to be a
primary driver of cell death in different forms of retinal degenerations. For example, mutations affecting…
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