grant
Phase I/II trial of sitagliptin, bortezomib and post-transplant cyclophosphamide for GvHD prophylaxis; IND 158327 (09/03/2021)
Organization FEINSTEIN INSTITUTE FOR MEDICAL RESEARCHLocation MANHASSET, UNITED STATESPosted 15 Sept 2023Deadline 31 Aug 2029
FDANIHUS FederalResearch GrantFY2023
Description preview
PROJECT SUMMARY
Acute and chronic graft-versus-host disease (GvHD) remain an important and potentially fatal complications of
allogeneic (HSCT). Despite current standard prophylactic regimens based on calcineurin inhibitors, grades II-IV
acute GVHD occurs in 34-51% of patients by day 100 after transplantation, and chronic GvHD occurs in up to
60%…
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